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The Vulnerability to Suicidal Behavior is Associated with Reduced Connectivity Strength.

Bijttebier S, Caeyenberghs K, van den Ameele H, Achten E, Rujescu D, Titeca K, van Heeringen C - Front Hum Neurosci (2015)

Bottom Line: Furthermore, SA had increased suicidal ideation, hopelessness and self-reported depression, but did not show any differences for the genetic polymorphisms.Finally, lower connectivity strength between the right calcarine fissure and the left middle occipital gyrus was associated with increased trait anxiety severity (rs = -0.78, p < 0.01) and hopelessness (rs = -0.76, p < 0.01).SA showed differences in white matter network connectivity strength associated with clinical characteristics.

View Article: PubMed Central - PubMed

Affiliation: Unit for Suicide Research, Department of Psychiatry and Medical Psychology, Ghent University Ghent, Belgium.

ABSTRACT
Suicidal behavior constitutes a major public health problem. Based on the stress-diathesis model, biological correlates of a diathesis might help to predict risk after stressor-exposure. Structural changes in cortical and subcortical areas and their connections have increasingly been linked with the diathesis. The current study identified structural network changes associated with a diathesis using a whole-brain approach by examining the structural connectivity between regions in euthymic suicide attempters (SA). In addition, the association between connectivity measures, clinical and genetic characteristics was investigated. We hypothesized that SA showed lower connectivity strength, associated with an increased severity of general clinical characteristics and an elevated expression of short alleles in serotonin polymorphisms. Thirteen euthymic SA were compared with fifteen euthymic non-attempters and seventeen healthy controls (HC). Clinical characteristics and three serotonin-related genetic polymorphisms were assessed. Diffusion MRI together with anatomical scans were administered. Preprocessing was performed using Explore DTI. Whole brain tractography of the diffusion-weighted images was followed by a number of streamlines-weighted network analysis using NBS. The network analysis revealed decreased connectivity strength in SA in the connections between the left olfactory cortex and left anterior cingulate gyrus. Furthermore, SA had increased suicidal ideation, hopelessness and self-reported depression, but did not show any differences for the genetic polymorphisms. Finally, lower connectivity strength between the right calcarine fissure and the left middle occipital gyrus was associated with increased trait anxiety severity (rs = -0.78, p < 0.01) and hopelessness (rs = -0.76, p < 0.01). SA showed differences in white matter network connectivity strength associated with clinical characteristics. Together, these variables could play an important role in predicting suicidal behavior.

No MeSH data available.


Related in: MedlinePlus

Graphical representation (axial view, radiological convention) of the network connections showing a significantly lower connectivity strength when comparing euthymic suicide attempters (SA) with euthymic non-attempters and healthy controls (HC). Green dots represent nodes. The blue line shows the connection between the left olfactory cortex and the left anterior cingulate gyrus, while the red line symbolizes the connection between the right medial orbital superior frontal gyrus and the right rectal gyrus. The purple line connects the right calcarine fissure and the left middle occipital gyrus. The yellow line forms the connection between the right calcarine fissure and both the left superior occipital gyrus.
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Figure 3: Graphical representation (axial view, radiological convention) of the network connections showing a significantly lower connectivity strength when comparing euthymic suicide attempters (SA) with euthymic non-attempters and healthy controls (HC). Green dots represent nodes. The blue line shows the connection between the left olfactory cortex and the left anterior cingulate gyrus, while the red line symbolizes the connection between the right medial orbital superior frontal gyrus and the right rectal gyrus. The purple line connects the right calcarine fissure and the left middle occipital gyrus. The yellow line forms the connection between the right calcarine fissure and both the left superior occipital gyrus.

Mentions: As shown in Table 2, post hoc tests revealed that SA, compared to HC and NA, showed decreased connectivity strength between the left olfactory cortex and the left anterior cingulate gyrus (Connection 1). There was a trend towards significance (p = 0.07) for decreased connectivity strength in SA between the right medial orbital superior frontal gyrus and the right rectal gyrus (Connection 2), and between the right calcarine fissure and both the left superior and middle occipital gyrus (Connections 3 and 4 respectively). HC and NA did not differ significantly for each of these connections (Figure 3).


The Vulnerability to Suicidal Behavior is Associated with Reduced Connectivity Strength.

Bijttebier S, Caeyenberghs K, van den Ameele H, Achten E, Rujescu D, Titeca K, van Heeringen C - Front Hum Neurosci (2015)

Graphical representation (axial view, radiological convention) of the network connections showing a significantly lower connectivity strength when comparing euthymic suicide attempters (SA) with euthymic non-attempters and healthy controls (HC). Green dots represent nodes. The blue line shows the connection between the left olfactory cortex and the left anterior cingulate gyrus, while the red line symbolizes the connection between the right medial orbital superior frontal gyrus and the right rectal gyrus. The purple line connects the right calcarine fissure and the left middle occipital gyrus. The yellow line forms the connection between the right calcarine fissure and both the left superior occipital gyrus.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4663245&req=5

Figure 3: Graphical representation (axial view, radiological convention) of the network connections showing a significantly lower connectivity strength when comparing euthymic suicide attempters (SA) with euthymic non-attempters and healthy controls (HC). Green dots represent nodes. The blue line shows the connection between the left olfactory cortex and the left anterior cingulate gyrus, while the red line symbolizes the connection between the right medial orbital superior frontal gyrus and the right rectal gyrus. The purple line connects the right calcarine fissure and the left middle occipital gyrus. The yellow line forms the connection between the right calcarine fissure and both the left superior occipital gyrus.
Mentions: As shown in Table 2, post hoc tests revealed that SA, compared to HC and NA, showed decreased connectivity strength between the left olfactory cortex and the left anterior cingulate gyrus (Connection 1). There was a trend towards significance (p = 0.07) for decreased connectivity strength in SA between the right medial orbital superior frontal gyrus and the right rectal gyrus (Connection 2), and between the right calcarine fissure and both the left superior and middle occipital gyrus (Connections 3 and 4 respectively). HC and NA did not differ significantly for each of these connections (Figure 3).

Bottom Line: Furthermore, SA had increased suicidal ideation, hopelessness and self-reported depression, but did not show any differences for the genetic polymorphisms.Finally, lower connectivity strength between the right calcarine fissure and the left middle occipital gyrus was associated with increased trait anxiety severity (rs = -0.78, p < 0.01) and hopelessness (rs = -0.76, p < 0.01).SA showed differences in white matter network connectivity strength associated with clinical characteristics.

View Article: PubMed Central - PubMed

Affiliation: Unit for Suicide Research, Department of Psychiatry and Medical Psychology, Ghent University Ghent, Belgium.

ABSTRACT
Suicidal behavior constitutes a major public health problem. Based on the stress-diathesis model, biological correlates of a diathesis might help to predict risk after stressor-exposure. Structural changes in cortical and subcortical areas and their connections have increasingly been linked with the diathesis. The current study identified structural network changes associated with a diathesis using a whole-brain approach by examining the structural connectivity between regions in euthymic suicide attempters (SA). In addition, the association between connectivity measures, clinical and genetic characteristics was investigated. We hypothesized that SA showed lower connectivity strength, associated with an increased severity of general clinical characteristics and an elevated expression of short alleles in serotonin polymorphisms. Thirteen euthymic SA were compared with fifteen euthymic non-attempters and seventeen healthy controls (HC). Clinical characteristics and three serotonin-related genetic polymorphisms were assessed. Diffusion MRI together with anatomical scans were administered. Preprocessing was performed using Explore DTI. Whole brain tractography of the diffusion-weighted images was followed by a number of streamlines-weighted network analysis using NBS. The network analysis revealed decreased connectivity strength in SA in the connections between the left olfactory cortex and left anterior cingulate gyrus. Furthermore, SA had increased suicidal ideation, hopelessness and self-reported depression, but did not show any differences for the genetic polymorphisms. Finally, lower connectivity strength between the right calcarine fissure and the left middle occipital gyrus was associated with increased trait anxiety severity (rs = -0.78, p < 0.01) and hopelessness (rs = -0.76, p < 0.01). SA showed differences in white matter network connectivity strength associated with clinical characteristics. Together, these variables could play an important role in predicting suicidal behavior.

No MeSH data available.


Related in: MedlinePlus