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The Vulnerability to Suicidal Behavior is Associated with Reduced Connectivity Strength.

Bijttebier S, Caeyenberghs K, van den Ameele H, Achten E, Rujescu D, Titeca K, van Heeringen C - Front Hum Neurosci (2015)

Bottom Line: Furthermore, SA had increased suicidal ideation, hopelessness and self-reported depression, but did not show any differences for the genetic polymorphisms.Finally, lower connectivity strength between the right calcarine fissure and the left middle occipital gyrus was associated with increased trait anxiety severity (rs = -0.78, p < 0.01) and hopelessness (rs = -0.76, p < 0.01).SA showed differences in white matter network connectivity strength associated with clinical characteristics.

View Article: PubMed Central - PubMed

Affiliation: Unit for Suicide Research, Department of Psychiatry and Medical Psychology, Ghent University Ghent, Belgium.

ABSTRACT
Suicidal behavior constitutes a major public health problem. Based on the stress-diathesis model, biological correlates of a diathesis might help to predict risk after stressor-exposure. Structural changes in cortical and subcortical areas and their connections have increasingly been linked with the diathesis. The current study identified structural network changes associated with a diathesis using a whole-brain approach by examining the structural connectivity between regions in euthymic suicide attempters (SA). In addition, the association between connectivity measures, clinical and genetic characteristics was investigated. We hypothesized that SA showed lower connectivity strength, associated with an increased severity of general clinical characteristics and an elevated expression of short alleles in serotonin polymorphisms. Thirteen euthymic SA were compared with fifteen euthymic non-attempters and seventeen healthy controls (HC). Clinical characteristics and three serotonin-related genetic polymorphisms were assessed. Diffusion MRI together with anatomical scans were administered. Preprocessing was performed using Explore DTI. Whole brain tractography of the diffusion-weighted images was followed by a number of streamlines-weighted network analysis using NBS. The network analysis revealed decreased connectivity strength in SA in the connections between the left olfactory cortex and left anterior cingulate gyrus. Furthermore, SA had increased suicidal ideation, hopelessness and self-reported depression, but did not show any differences for the genetic polymorphisms. Finally, lower connectivity strength between the right calcarine fissure and the left middle occipital gyrus was associated with increased trait anxiety severity (rs = -0.78, p < 0.01) and hopelessness (rs = -0.76, p < 0.01). SA showed differences in white matter network connectivity strength associated with clinical characteristics. Together, these variables could play an important role in predicting suicidal behavior.

No MeSH data available.


Related in: MedlinePlus

(A–C) Between group structural connectivity alterations. Respectively the axial (A), coronal (B) and sagittal (C) view of the subnetwork, which demonstrated significant alterations in structural connectivity between the three groups. This network comprises 34 nodes and 36 edges. Each node is labelled with the anatomical name used in the AAL template. The lines represent the edges of the observed network, while the green dots symbolize the network nodes. The darker the line, the higher the strength of the network connection between a pair of nodes (with red being the highest connectivity strength, and white the lowest connectivity strength). Visualization: Explore DTI, version 4.8.4 (Leemans et al., 2009).
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Figure 2: (A–C) Between group structural connectivity alterations. Respectively the axial (A), coronal (B) and sagittal (C) view of the subnetwork, which demonstrated significant alterations in structural connectivity between the three groups. This network comprises 34 nodes and 36 edges. Each node is labelled with the anatomical name used in the AAL template. The lines represent the edges of the observed network, while the green dots symbolize the network nodes. The darker the line, the higher the strength of the network connection between a pair of nodes (with red being the highest connectivity strength, and white the lowest connectivity strength). Visualization: Explore DTI, version 4.8.4 (Leemans et al., 2009).

Mentions: The NBS method identified one subnetwork (p < 0.05 family-wise-error corrected), consisting of 34 nodes and 36 connections, with significant alterations in structural connectivity between the three groups. This subnetwork encompassed both cortical, as well as subcortical regions (such as the amygdala, the anterior cingulum, the caudate and putamen) (F = 4.33, p < 0.05; Figures 2A–C).


The Vulnerability to Suicidal Behavior is Associated with Reduced Connectivity Strength.

Bijttebier S, Caeyenberghs K, van den Ameele H, Achten E, Rujescu D, Titeca K, van Heeringen C - Front Hum Neurosci (2015)

(A–C) Between group structural connectivity alterations. Respectively the axial (A), coronal (B) and sagittal (C) view of the subnetwork, which demonstrated significant alterations in structural connectivity between the three groups. This network comprises 34 nodes and 36 edges. Each node is labelled with the anatomical name used in the AAL template. The lines represent the edges of the observed network, while the green dots symbolize the network nodes. The darker the line, the higher the strength of the network connection between a pair of nodes (with red being the highest connectivity strength, and white the lowest connectivity strength). Visualization: Explore DTI, version 4.8.4 (Leemans et al., 2009).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4663245&req=5

Figure 2: (A–C) Between group structural connectivity alterations. Respectively the axial (A), coronal (B) and sagittal (C) view of the subnetwork, which demonstrated significant alterations in structural connectivity between the three groups. This network comprises 34 nodes and 36 edges. Each node is labelled with the anatomical name used in the AAL template. The lines represent the edges of the observed network, while the green dots symbolize the network nodes. The darker the line, the higher the strength of the network connection between a pair of nodes (with red being the highest connectivity strength, and white the lowest connectivity strength). Visualization: Explore DTI, version 4.8.4 (Leemans et al., 2009).
Mentions: The NBS method identified one subnetwork (p < 0.05 family-wise-error corrected), consisting of 34 nodes and 36 connections, with significant alterations in structural connectivity between the three groups. This subnetwork encompassed both cortical, as well as subcortical regions (such as the amygdala, the anterior cingulum, the caudate and putamen) (F = 4.33, p < 0.05; Figures 2A–C).

Bottom Line: Furthermore, SA had increased suicidal ideation, hopelessness and self-reported depression, but did not show any differences for the genetic polymorphisms.Finally, lower connectivity strength between the right calcarine fissure and the left middle occipital gyrus was associated with increased trait anxiety severity (rs = -0.78, p < 0.01) and hopelessness (rs = -0.76, p < 0.01).SA showed differences in white matter network connectivity strength associated with clinical characteristics.

View Article: PubMed Central - PubMed

Affiliation: Unit for Suicide Research, Department of Psychiatry and Medical Psychology, Ghent University Ghent, Belgium.

ABSTRACT
Suicidal behavior constitutes a major public health problem. Based on the stress-diathesis model, biological correlates of a diathesis might help to predict risk after stressor-exposure. Structural changes in cortical and subcortical areas and their connections have increasingly been linked with the diathesis. The current study identified structural network changes associated with a diathesis using a whole-brain approach by examining the structural connectivity between regions in euthymic suicide attempters (SA). In addition, the association between connectivity measures, clinical and genetic characteristics was investigated. We hypothesized that SA showed lower connectivity strength, associated with an increased severity of general clinical characteristics and an elevated expression of short alleles in serotonin polymorphisms. Thirteen euthymic SA were compared with fifteen euthymic non-attempters and seventeen healthy controls (HC). Clinical characteristics and three serotonin-related genetic polymorphisms were assessed. Diffusion MRI together with anatomical scans were administered. Preprocessing was performed using Explore DTI. Whole brain tractography of the diffusion-weighted images was followed by a number of streamlines-weighted network analysis using NBS. The network analysis revealed decreased connectivity strength in SA in the connections between the left olfactory cortex and left anterior cingulate gyrus. Furthermore, SA had increased suicidal ideation, hopelessness and self-reported depression, but did not show any differences for the genetic polymorphisms. Finally, lower connectivity strength between the right calcarine fissure and the left middle occipital gyrus was associated with increased trait anxiety severity (rs = -0.78, p < 0.01) and hopelessness (rs = -0.76, p < 0.01). SA showed differences in white matter network connectivity strength associated with clinical characteristics. Together, these variables could play an important role in predicting suicidal behavior.

No MeSH data available.


Related in: MedlinePlus