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Bioactive Glasses: Frontiers and Challenges.

Hench LL, Jones JR - Front Bioeng Biotechnol (2015)

Bottom Line: Bioglass formed a rapid, strong, and stable bond with host tissues.This article summarizes the frontiers of knowledge crossed during four eras of development of bioactive glasses that have led from concept of bioactivity to widespread clinical and commercial use, with emphasis on the first composition, 45S5 Bioglass(®).The four eras are (a) discovery, (b) clinical application, (c) tissue regeneration, and (d) innovation.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomedical Engineering, Florida Institute of Technology , Melbourne, FL , USA.

ABSTRACT
Bioactive glasses were discovered in 1969 and provided for the first time an alternative to nearly inert implant materials. Bioglass formed a rapid, strong, and stable bond with host tissues. This article examines the frontiers of research crossed to achieve clinical use of bioactive glasses and glass-ceramics. In the 1980s, it was discovered that bioactive glasses could be used in particulate form to stimulate osteogenesis, which thereby led to the concept of regeneration of tissues. Later, it was discovered that the dissolution ions from the glasses behaved like growth factors, providing signals to the cells. This article summarizes the frontiers of knowledge crossed during four eras of development of bioactive glasses that have led from concept of bioactivity to widespread clinical and commercial use, with emphasis on the first composition, 45S5 Bioglass(®). The four eras are (a) discovery, (b) clinical application, (c) tissue regeneration, and (d) innovation. Questions still to be answered for the fourth era are included to stimulate innovation in the field and exploration of new frontiers that can be the basis for a general theory of bioactive stimulation of regeneration of tissues and application to numerous clinical needs.

No MeSH data available.


Related in: MedlinePlus

(A) Packaging of NovaBone (45S5 Bioglass) powder for orthopedic applications and (B) scanning electron micrograph of NovaBone particles. Modified with permission from Jones (2013).
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Figure 2: (A) Packaging of NovaBone (45S5 Bioglass) powder for orthopedic applications and (B) scanning electron micrograph of NovaBone particles. Modified with permission from Jones (2013).

Mentions: The discovery of osteoproduction (osteostimulation) and the concept of using Bioglass particulate for regeneration of bone was the key frontier crossed that led to the Era of Tissue Regeneration. Wilson et al. described the effect of various sizes of Bioglass particulate on regeneration of bone in periodontal defects created in a monkey model (Wilson and Low, 1992). The seminal finding was the stimulation of new bone throughout the defect. Bone growth was initiated at the surface of the bioactive glass particles and rapidly formed connections between the particles regenerating a trabecular bone network that mimicked the original trabecular bone of the jaw prior to creating the defect. The study showed that there was an optimal rate of bone repair when a range of particle sizes of Bioglass was used. The results also showed that bone regeneration was sufficiently rapid that it prevented encapsulation of the site by epithelial tissues. The data provided the foundation for a clinical trial in patients at the University of Florida that led to FDA regulatory approval of the use of bioactive glass particulate for periodontal repair (Perioglas, NovaBone Products LLC, Alachua, FL, USA; Figure 2).


Bioactive Glasses: Frontiers and Challenges.

Hench LL, Jones JR - Front Bioeng Biotechnol (2015)

(A) Packaging of NovaBone (45S5 Bioglass) powder for orthopedic applications and (B) scanning electron micrograph of NovaBone particles. Modified with permission from Jones (2013).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4663244&req=5

Figure 2: (A) Packaging of NovaBone (45S5 Bioglass) powder for orthopedic applications and (B) scanning electron micrograph of NovaBone particles. Modified with permission from Jones (2013).
Mentions: The discovery of osteoproduction (osteostimulation) and the concept of using Bioglass particulate for regeneration of bone was the key frontier crossed that led to the Era of Tissue Regeneration. Wilson et al. described the effect of various sizes of Bioglass particulate on regeneration of bone in periodontal defects created in a monkey model (Wilson and Low, 1992). The seminal finding was the stimulation of new bone throughout the defect. Bone growth was initiated at the surface of the bioactive glass particles and rapidly formed connections between the particles regenerating a trabecular bone network that mimicked the original trabecular bone of the jaw prior to creating the defect. The study showed that there was an optimal rate of bone repair when a range of particle sizes of Bioglass was used. The results also showed that bone regeneration was sufficiently rapid that it prevented encapsulation of the site by epithelial tissues. The data provided the foundation for a clinical trial in patients at the University of Florida that led to FDA regulatory approval of the use of bioactive glass particulate for periodontal repair (Perioglas, NovaBone Products LLC, Alachua, FL, USA; Figure 2).

Bottom Line: Bioglass formed a rapid, strong, and stable bond with host tissues.This article summarizes the frontiers of knowledge crossed during four eras of development of bioactive glasses that have led from concept of bioactivity to widespread clinical and commercial use, with emphasis on the first composition, 45S5 Bioglass(®).The four eras are (a) discovery, (b) clinical application, (c) tissue regeneration, and (d) innovation.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomedical Engineering, Florida Institute of Technology , Melbourne, FL , USA.

ABSTRACT
Bioactive glasses were discovered in 1969 and provided for the first time an alternative to nearly inert implant materials. Bioglass formed a rapid, strong, and stable bond with host tissues. This article examines the frontiers of research crossed to achieve clinical use of bioactive glasses and glass-ceramics. In the 1980s, it was discovered that bioactive glasses could be used in particulate form to stimulate osteogenesis, which thereby led to the concept of regeneration of tissues. Later, it was discovered that the dissolution ions from the glasses behaved like growth factors, providing signals to the cells. This article summarizes the frontiers of knowledge crossed during four eras of development of bioactive glasses that have led from concept of bioactivity to widespread clinical and commercial use, with emphasis on the first composition, 45S5 Bioglass(®). The four eras are (a) discovery, (b) clinical application, (c) tissue regeneration, and (d) innovation. Questions still to be answered for the fourth era are included to stimulate innovation in the field and exploration of new frontiers that can be the basis for a general theory of bioactive stimulation of regeneration of tissues and application to numerous clinical needs.

No MeSH data available.


Related in: MedlinePlus