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Factors affecting medication discontinuation in patients with overactive bladder symptoms.

Shim EJ, Yoo EH, Kim YM, Kim D - Obstet Gynecol Sci (2015)

Bottom Line: The reasons of discontinuation of antimuscarinics were improved OAB symptoms (46.7%), tolerable OAB symptoms (33.3%), no change of OAB symptoms (1.3%), side-effects (8.0%) and no desire to take long-term medication (10.7%).The lower rate of cumulative continuation of antimuscarinics encourages us to give a more detailed counseling and education to the patients with OAB symptoms before prescription.And explorations about newer agent and non-pharmacologic treatment with good efficacy and lower side-effects are needed.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Kyung Hee University Hospital, Seoul, Korea.

ABSTRACT

Objective: To find out the factors affecting medication discontinuation in patients with overactive bladder (OAB) symptoms.

Methods: The clinical data of 125 patients with OAB symptoms who had taken antimuscarinics and behavioral therapy were retrospectively reviewed. Antimuscarinics related outcomes were evaluated by an independent observer with telephone interview. All patients were asked about duration of medication and reason of continuation or discontinuation of antimuscarinics. To determine pre-treatment factors predicting self-report discontinuation of antimuscarinics, variables of only those with P-values <0.25 on the univariate analysis were included in the Cox proportional hazard modeling.

Results: Mean follow-up was 39.6 months and the proportion of discontinuation of antimuscarinics was 60.0% (75/125). The mean duration of medication was 21.2 months in the continuation group and 3.3 months in the discontinuation group. The reasons of discontinuation of antimuscarinics were improved OAB symptoms (46.7%), tolerable OAB symptoms (33.3%), no change of OAB symptoms (1.3%), side-effects (8.0%) and no desire to take long-term medication (10.7%). The variables affecting remaining cumulative probability of antimuscarinics were age, history of anti-incontinence surgery or vaginal surgery, and having stress predominant urinary incontinence on urodynamic study.

Conclusion: The lower rate of cumulative continuation of antimuscarinics encourages us to give a more detailed counseling and education to the patients with OAB symptoms before prescription. And explorations about newer agent and non-pharmacologic treatment with good efficacy and lower side-effects are needed.

No MeSH data available.


Related in: MedlinePlus

Cumulative probability of remaining on the antimuscarinics according to age.
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Figure 1: Cumulative probability of remaining on the antimuscarinics according to age.

Mentions: Those who were older aged, not having stress predominant urinary incontinence on urodynamic study and had not received anti-incontinence operation or surgery for vaginal prolapse had a higher adjusted cumulative probability of remaining on the antimuscarinics treatment in the Cox proportional hazards regression model (Table 4). Kaplan-Meier curves illustrate the association between age and continuation group >55 years as cut-off level (P=0.02, log rank test) (Fig. 1).


Factors affecting medication discontinuation in patients with overactive bladder symptoms.

Shim EJ, Yoo EH, Kim YM, Kim D - Obstet Gynecol Sci (2015)

Cumulative probability of remaining on the antimuscarinics according to age.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4663230&req=5

Figure 1: Cumulative probability of remaining on the antimuscarinics according to age.
Mentions: Those who were older aged, not having stress predominant urinary incontinence on urodynamic study and had not received anti-incontinence operation or surgery for vaginal prolapse had a higher adjusted cumulative probability of remaining on the antimuscarinics treatment in the Cox proportional hazards regression model (Table 4). Kaplan-Meier curves illustrate the association between age and continuation group >55 years as cut-off level (P=0.02, log rank test) (Fig. 1).

Bottom Line: The reasons of discontinuation of antimuscarinics were improved OAB symptoms (46.7%), tolerable OAB symptoms (33.3%), no change of OAB symptoms (1.3%), side-effects (8.0%) and no desire to take long-term medication (10.7%).The lower rate of cumulative continuation of antimuscarinics encourages us to give a more detailed counseling and education to the patients with OAB symptoms before prescription.And explorations about newer agent and non-pharmacologic treatment with good efficacy and lower side-effects are needed.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Kyung Hee University Hospital, Seoul, Korea.

ABSTRACT

Objective: To find out the factors affecting medication discontinuation in patients with overactive bladder (OAB) symptoms.

Methods: The clinical data of 125 patients with OAB symptoms who had taken antimuscarinics and behavioral therapy were retrospectively reviewed. Antimuscarinics related outcomes were evaluated by an independent observer with telephone interview. All patients were asked about duration of medication and reason of continuation or discontinuation of antimuscarinics. To determine pre-treatment factors predicting self-report discontinuation of antimuscarinics, variables of only those with P-values <0.25 on the univariate analysis were included in the Cox proportional hazard modeling.

Results: Mean follow-up was 39.6 months and the proportion of discontinuation of antimuscarinics was 60.0% (75/125). The mean duration of medication was 21.2 months in the continuation group and 3.3 months in the discontinuation group. The reasons of discontinuation of antimuscarinics were improved OAB symptoms (46.7%), tolerable OAB symptoms (33.3%), no change of OAB symptoms (1.3%), side-effects (8.0%) and no desire to take long-term medication (10.7%). The variables affecting remaining cumulative probability of antimuscarinics were age, history of anti-incontinence surgery or vaginal surgery, and having stress predominant urinary incontinence on urodynamic study.

Conclusion: The lower rate of cumulative continuation of antimuscarinics encourages us to give a more detailed counseling and education to the patients with OAB symptoms before prescription. And explorations about newer agent and non-pharmacologic treatment with good efficacy and lower side-effects are needed.

No MeSH data available.


Related in: MedlinePlus