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Uterine blood flow indices, antinuclear autoantibodies and unexplained recurrent miscarriage.

Pietropolli A, Bruno V, Capogna MV, Bernardini S, Piccione E, Ticconi C - Obstet Gynecol Sci (2015)

Bottom Line: Pulsatility index of ANA+ uRM women was higher than that of ANA- uRM women and control ANA+ and ANAwomen, both in the follicular and in the midluteal phase of the cycle.Flow index in uRM ANA+ women was significantly lower than that of each of the other groups.ANA might be involved in uRM by determining an impairment in uterine blood flow hemodynamic, particularly in uterine blood flow intensity and uterine artery impedance.

View Article: PubMed Central - PubMed

Affiliation: Academic Department of Biomedicine and Prevention, Section of Gynecology and Obstetrics, Tor Vergata University, Rome, Italy.

ABSTRACT

Objective: To study the correlation between 2D and 3D uterine flow indexes and the presence or the absence of antinuclear antibodies (ANA) in women with unexplained recurrent miscarriage (uRM).

Methods: Fifty-two subjects (26 uRM and 26 control women) underwent 2D Doppler measurement of pulsatility index and resistance index of the uterine arteries in both the follicular and midluteal phase of the cycle. Additionally, 3D ultrasonography determination of vascularisation index, flow index, and vascularisation flow index was carried out with the aid of the VOCAL technique. Serum assay for the presence of ANA was performed in all women.

Results: Pulsatility index of ANA+ uRM women was higher than that of ANA- uRM women and control ANA+ and ANAwomen, both in the follicular and in the midluteal phase of the cycle. Vascularisation index in ANA- uRM women was significantly higher than that in ANA+ control women. Flow index in uRM ANA+ women was significantly lower than that of each of the other groups.

Conclusion: ANA might be involved in uRM by determining an impairment in uterine blood flow hemodynamic, particularly in uterine blood flow intensity and uterine artery impedance.

No MeSH data available.


Related in: MedlinePlus

Three-dimentional ultrasound analysis of uterine vascularization indexes. Flow and vascularization indexes in unexplained recurrent miscarriage (RM) women antinuclear antibodies (ANA)- (n=26) and ANA+ (n=26), as well as in control women ANA- (n=26) and ANA+ (n=26), measured in the midluteal phase of the cycle. (A) Vascularisation index, (B) flow index, and (C) vascularisation flow index. Data are expressed as means±SD for parametric values (B) and as median (range) for the non parametric ones (A,C). *One-way analysis of variance P=0.01, *SNK P<0.05 vs. all other groups. **KRUSKAL-WALLIS statistic 9.498, P<0.05, **Dunn P<0.001 for RM women ANA- vs. control women ANA+.
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Figure 2: Three-dimentional ultrasound analysis of uterine vascularization indexes. Flow and vascularization indexes in unexplained recurrent miscarriage (RM) women antinuclear antibodies (ANA)- (n=26) and ANA+ (n=26), as well as in control women ANA- (n=26) and ANA+ (n=26), measured in the midluteal phase of the cycle. (A) Vascularisation index, (B) flow index, and (C) vascularisation flow index. Data are expressed as means±SD for parametric values (B) and as median (range) for the non parametric ones (A,C). *One-way analysis of variance P=0.01, *SNK P<0.05 vs. all other groups. **KRUSKAL-WALLIS statistic 9.498, P<0.05, **Dunn P<0.001 for RM women ANA- vs. control women ANA+.

Mentions: Three-D ultrasound analysis of uterine flux and vascularization indexes revealed that VI in ANA- uRM women was significantly higher than that in ANA+ control women (Fig. 2A). No other differences could be found when VI was compared among any other group (Fig. 2A). FI in uRM ANA+ women was significantly lower than that of each of the other groups (uRM ANA- and control ANA- and ANA+ women) (Fig. 2B). No differences were found in VFI in any of the study groups (Fig. 2C).


Uterine blood flow indices, antinuclear autoantibodies and unexplained recurrent miscarriage.

Pietropolli A, Bruno V, Capogna MV, Bernardini S, Piccione E, Ticconi C - Obstet Gynecol Sci (2015)

Three-dimentional ultrasound analysis of uterine vascularization indexes. Flow and vascularization indexes in unexplained recurrent miscarriage (RM) women antinuclear antibodies (ANA)- (n=26) and ANA+ (n=26), as well as in control women ANA- (n=26) and ANA+ (n=26), measured in the midluteal phase of the cycle. (A) Vascularisation index, (B) flow index, and (C) vascularisation flow index. Data are expressed as means±SD for parametric values (B) and as median (range) for the non parametric ones (A,C). *One-way analysis of variance P=0.01, *SNK P<0.05 vs. all other groups. **KRUSKAL-WALLIS statistic 9.498, P<0.05, **Dunn P<0.001 for RM women ANA- vs. control women ANA+.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4663222&req=5

Figure 2: Three-dimentional ultrasound analysis of uterine vascularization indexes. Flow and vascularization indexes in unexplained recurrent miscarriage (RM) women antinuclear antibodies (ANA)- (n=26) and ANA+ (n=26), as well as in control women ANA- (n=26) and ANA+ (n=26), measured in the midluteal phase of the cycle. (A) Vascularisation index, (B) flow index, and (C) vascularisation flow index. Data are expressed as means±SD for parametric values (B) and as median (range) for the non parametric ones (A,C). *One-way analysis of variance P=0.01, *SNK P<0.05 vs. all other groups. **KRUSKAL-WALLIS statistic 9.498, P<0.05, **Dunn P<0.001 for RM women ANA- vs. control women ANA+.
Mentions: Three-D ultrasound analysis of uterine flux and vascularization indexes revealed that VI in ANA- uRM women was significantly higher than that in ANA+ control women (Fig. 2A). No other differences could be found when VI was compared among any other group (Fig. 2A). FI in uRM ANA+ women was significantly lower than that of each of the other groups (uRM ANA- and control ANA- and ANA+ women) (Fig. 2B). No differences were found in VFI in any of the study groups (Fig. 2C).

Bottom Line: Pulsatility index of ANA+ uRM women was higher than that of ANA- uRM women and control ANA+ and ANAwomen, both in the follicular and in the midluteal phase of the cycle.Flow index in uRM ANA+ women was significantly lower than that of each of the other groups.ANA might be involved in uRM by determining an impairment in uterine blood flow hemodynamic, particularly in uterine blood flow intensity and uterine artery impedance.

View Article: PubMed Central - PubMed

Affiliation: Academic Department of Biomedicine and Prevention, Section of Gynecology and Obstetrics, Tor Vergata University, Rome, Italy.

ABSTRACT

Objective: To study the correlation between 2D and 3D uterine flow indexes and the presence or the absence of antinuclear antibodies (ANA) in women with unexplained recurrent miscarriage (uRM).

Methods: Fifty-two subjects (26 uRM and 26 control women) underwent 2D Doppler measurement of pulsatility index and resistance index of the uterine arteries in both the follicular and midluteal phase of the cycle. Additionally, 3D ultrasonography determination of vascularisation index, flow index, and vascularisation flow index was carried out with the aid of the VOCAL technique. Serum assay for the presence of ANA was performed in all women.

Results: Pulsatility index of ANA+ uRM women was higher than that of ANA- uRM women and control ANA+ and ANAwomen, both in the follicular and in the midluteal phase of the cycle. Vascularisation index in ANA- uRM women was significantly higher than that in ANA+ control women. Flow index in uRM ANA+ women was significantly lower than that of each of the other groups.

Conclusion: ANA might be involved in uRM by determining an impairment in uterine blood flow hemodynamic, particularly in uterine blood flow intensity and uterine artery impedance.

No MeSH data available.


Related in: MedlinePlus