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Uterine blood flow indices, antinuclear autoantibodies and unexplained recurrent miscarriage.

Pietropolli A, Bruno V, Capogna MV, Bernardini S, Piccione E, Ticconi C - Obstet Gynecol Sci (2015)

Bottom Line: Pulsatility index of ANA+ uRM women was higher than that of ANA- uRM women and control ANA+ and ANAwomen, both in the follicular and in the midluteal phase of the cycle.Flow index in uRM ANA+ women was significantly lower than that of each of the other groups.ANA might be involved in uRM by determining an impairment in uterine blood flow hemodynamic, particularly in uterine blood flow intensity and uterine artery impedance.

View Article: PubMed Central - PubMed

Affiliation: Academic Department of Biomedicine and Prevention, Section of Gynecology and Obstetrics, Tor Vergata University, Rome, Italy.

ABSTRACT

Objective: To study the correlation between 2D and 3D uterine flow indexes and the presence or the absence of antinuclear antibodies (ANA) in women with unexplained recurrent miscarriage (uRM).

Methods: Fifty-two subjects (26 uRM and 26 control women) underwent 2D Doppler measurement of pulsatility index and resistance index of the uterine arteries in both the follicular and midluteal phase of the cycle. Additionally, 3D ultrasonography determination of vascularisation index, flow index, and vascularisation flow index was carried out with the aid of the VOCAL technique. Serum assay for the presence of ANA was performed in all women.

Results: Pulsatility index of ANA+ uRM women was higher than that of ANA- uRM women and control ANA+ and ANAwomen, both in the follicular and in the midluteal phase of the cycle. Vascularisation index in ANA- uRM women was significantly higher than that in ANA+ control women. Flow index in uRM ANA+ women was significantly lower than that of each of the other groups.

Conclusion: ANA might be involved in uRM by determining an impairment in uterine blood flow hemodynamic, particularly in uterine blood flow intensity and uterine artery impedance.

No MeSH data available.


Related in: MedlinePlus

Two-dimentional ultrasound analysis of uterine flux indexes. Flow and vascularization indexes in unexplained recurrent miscarriage (RM) women antinuclear antibodies (ANA)- (n=26) and ANA+ (n=26), and in controls woman ANA- (n=26) and ANA+ (n=26). In each women flow indexes (pulsatility index and resistance index) values were obtained in the follicular and in the mid-luteal phase. (A) Pulsatility index in follicular phase, (B) pulsatility index in mid-luteal phase, (C) resistivity index in follicular phase, and (D) resistivity index in mid-luteal phase. Data are expressed as mean±standard deviation. *One-way analysis of variance P<0.01, F=2.958; *SNK P<0.05 vs. all other groups.
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Figure 1: Two-dimentional ultrasound analysis of uterine flux indexes. Flow and vascularization indexes in unexplained recurrent miscarriage (RM) women antinuclear antibodies (ANA)- (n=26) and ANA+ (n=26), and in controls woman ANA- (n=26) and ANA+ (n=26). In each women flow indexes (pulsatility index and resistance index) values were obtained in the follicular and in the mid-luteal phase. (A) Pulsatility index in follicular phase, (B) pulsatility index in mid-luteal phase, (C) resistivity index in follicular phase, and (D) resistivity index in mid-luteal phase. Data are expressed as mean±standard deviation. *One-way analysis of variance P<0.01, F=2.958; *SNK P<0.05 vs. all other groups.

Mentions: Two-D ultrasound analysis of uterine flux indexes showed that the PI of ANA+ uRM women was significantly higher than that of each the other groups (ANA- uRM women and control ANA+ and ANA- women). This finding has been detected in both the follicular phase and the midluteal phase of the cycle (Fig. 1A, B). Conversely, no differences were found in RI between uRM and control women, irrespective of the ANA status and of the phase of the cycle (Fig. 1C, D). ANA status (ANA+ or ANA-) at the time of sampling during the midulteal phase of the cycle remained unchanged in each woman compared to ANA status at the enrollment into the study.


Uterine blood flow indices, antinuclear autoantibodies and unexplained recurrent miscarriage.

Pietropolli A, Bruno V, Capogna MV, Bernardini S, Piccione E, Ticconi C - Obstet Gynecol Sci (2015)

Two-dimentional ultrasound analysis of uterine flux indexes. Flow and vascularization indexes in unexplained recurrent miscarriage (RM) women antinuclear antibodies (ANA)- (n=26) and ANA+ (n=26), and in controls woman ANA- (n=26) and ANA+ (n=26). In each women flow indexes (pulsatility index and resistance index) values were obtained in the follicular and in the mid-luteal phase. (A) Pulsatility index in follicular phase, (B) pulsatility index in mid-luteal phase, (C) resistivity index in follicular phase, and (D) resistivity index in mid-luteal phase. Data are expressed as mean±standard deviation. *One-way analysis of variance P<0.01, F=2.958; *SNK P<0.05 vs. all other groups.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4663222&req=5

Figure 1: Two-dimentional ultrasound analysis of uterine flux indexes. Flow and vascularization indexes in unexplained recurrent miscarriage (RM) women antinuclear antibodies (ANA)- (n=26) and ANA+ (n=26), and in controls woman ANA- (n=26) and ANA+ (n=26). In each women flow indexes (pulsatility index and resistance index) values were obtained in the follicular and in the mid-luteal phase. (A) Pulsatility index in follicular phase, (B) pulsatility index in mid-luteal phase, (C) resistivity index in follicular phase, and (D) resistivity index in mid-luteal phase. Data are expressed as mean±standard deviation. *One-way analysis of variance P<0.01, F=2.958; *SNK P<0.05 vs. all other groups.
Mentions: Two-D ultrasound analysis of uterine flux indexes showed that the PI of ANA+ uRM women was significantly higher than that of each the other groups (ANA- uRM women and control ANA+ and ANA- women). This finding has been detected in both the follicular phase and the midluteal phase of the cycle (Fig. 1A, B). Conversely, no differences were found in RI between uRM and control women, irrespective of the ANA status and of the phase of the cycle (Fig. 1C, D). ANA status (ANA+ or ANA-) at the time of sampling during the midulteal phase of the cycle remained unchanged in each woman compared to ANA status at the enrollment into the study.

Bottom Line: Pulsatility index of ANA+ uRM women was higher than that of ANA- uRM women and control ANA+ and ANAwomen, both in the follicular and in the midluteal phase of the cycle.Flow index in uRM ANA+ women was significantly lower than that of each of the other groups.ANA might be involved in uRM by determining an impairment in uterine blood flow hemodynamic, particularly in uterine blood flow intensity and uterine artery impedance.

View Article: PubMed Central - PubMed

Affiliation: Academic Department of Biomedicine and Prevention, Section of Gynecology and Obstetrics, Tor Vergata University, Rome, Italy.

ABSTRACT

Objective: To study the correlation between 2D and 3D uterine flow indexes and the presence or the absence of antinuclear antibodies (ANA) in women with unexplained recurrent miscarriage (uRM).

Methods: Fifty-two subjects (26 uRM and 26 control women) underwent 2D Doppler measurement of pulsatility index and resistance index of the uterine arteries in both the follicular and midluteal phase of the cycle. Additionally, 3D ultrasonography determination of vascularisation index, flow index, and vascularisation flow index was carried out with the aid of the VOCAL technique. Serum assay for the presence of ANA was performed in all women.

Results: Pulsatility index of ANA+ uRM women was higher than that of ANA- uRM women and control ANA+ and ANAwomen, both in the follicular and in the midluteal phase of the cycle. Vascularisation index in ANA- uRM women was significantly higher than that in ANA+ control women. Flow index in uRM ANA+ women was significantly lower than that of each of the other groups.

Conclusion: ANA might be involved in uRM by determining an impairment in uterine blood flow hemodynamic, particularly in uterine blood flow intensity and uterine artery impedance.

No MeSH data available.


Related in: MedlinePlus