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Discordant associations of lipid parameters with albuminuria and chronic kidney disease: a population-based study.

Sun K, Lin D, Li F, Huang C, Qi Y, Xue S, Tang J, Yang C, Li Y, Ren M, Yan L - Lipids Health Dis (2015)

Bottom Line: Triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), Non HDL-C to HDL-C ratio, TG to HDL-C ratio were significantly correlated with urinary albumin to creatinine ratio (ACR), serum creatinine and eGFR (all P < 0.0001).No significant associations between lipid parameters and low-grade albuminuria were observed after adjustments for potential confounding factors.TG to HDL-C ratio is a better marker than other routine lipid measures for identifying renal insufficiency and should be given more consideration in the clinical practice.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, People's Republic of China.

ABSTRACT

Background: Although dyslipidemia is related to the pathogenesis of renal insufficiency, which routinely available lipid measure is more applicable in estimation of kidney function is still uncertain. Our objective was to evaluate inconsistent associations of lipid profiles with both albuminuria and chronic kidney disease (CKD).

Methods: We performed a population-based study in 9730 subjects aged 40 years or older. Definitions of abnormalities in albumin excretion were according to the latest guidelines of American Diabetes Association's Standards of Medical Care. CKD was defined as estimated glomerular filtration rate (eGFR) < 60 mL/min per 1.73 m(2) or the presence of albuminuria.

Results: There were 2274 (23.4%) participants categorized as low-grade albuminuria, 639 (6.6%) participants categorized as increased urinary albumin excretion and 689 (7.1%) participants categorized as CKD. Triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), Non HDL-C to HDL-C ratio, TG to HDL-C ratio were significantly correlated with urinary albumin to creatinine ratio (ACR), serum creatinine and eGFR (all P < 0.0001). Compare with other lipid parameters, TG to HDL-C ratio have shown the strongest correlation with increased odds of both increased urinary albumin excretion and CKD. No significant associations between lipid parameters and low-grade albuminuria were observed after adjustments for potential confounding factors.

Conclusion: Our study lends support to discordant associations of lipid parameters with albuminuria and renal function. TG to HDL-C ratio is a better marker than other routine lipid measures for identifying renal insufficiency and should be given more consideration in the clinical practice.

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Related in: MedlinePlus

Prevalence of low-grade albuminuria, increased urinary albumin excretion and CKD in quartiles of different lipid profiles
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Fig1: Prevalence of low-grade albuminuria, increased urinary albumin excretion and CKD in quartiles of different lipid profiles

Mentions: Figure 1 showed the prevalent low-grade albuminuria, increased urinary albumin excretion and CKD in different lipid parameters quartiles. The prevalence of albuminuria and CKD were tended to increase with the elevated TG, Non-HDL-C, Non-HDL-C/HDL-C and TG/HDL-C quartiles (all P for trend < 0.001). For both prevalent increased urinary albumin excretion and CKD, no obvious trend differences were detected in subjects with different quartiles of TC and LDL-C. The prevalence of low-grade albuminuria tended to increase with lipid parameters quartiles except for HDL-C and LDL-C.Fig. 1


Discordant associations of lipid parameters with albuminuria and chronic kidney disease: a population-based study.

Sun K, Lin D, Li F, Huang C, Qi Y, Xue S, Tang J, Yang C, Li Y, Ren M, Yan L - Lipids Health Dis (2015)

Prevalence of low-grade albuminuria, increased urinary albumin excretion and CKD in quartiles of different lipid profiles
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4660634&req=5

Fig1: Prevalence of low-grade albuminuria, increased urinary albumin excretion and CKD in quartiles of different lipid profiles
Mentions: Figure 1 showed the prevalent low-grade albuminuria, increased urinary albumin excretion and CKD in different lipid parameters quartiles. The prevalence of albuminuria and CKD were tended to increase with the elevated TG, Non-HDL-C, Non-HDL-C/HDL-C and TG/HDL-C quartiles (all P for trend < 0.001). For both prevalent increased urinary albumin excretion and CKD, no obvious trend differences were detected in subjects with different quartiles of TC and LDL-C. The prevalence of low-grade albuminuria tended to increase with lipid parameters quartiles except for HDL-C and LDL-C.Fig. 1

Bottom Line: Triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), Non HDL-C to HDL-C ratio, TG to HDL-C ratio were significantly correlated with urinary albumin to creatinine ratio (ACR), serum creatinine and eGFR (all P < 0.0001).No significant associations between lipid parameters and low-grade albuminuria were observed after adjustments for potential confounding factors.TG to HDL-C ratio is a better marker than other routine lipid measures for identifying renal insufficiency and should be given more consideration in the clinical practice.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, People's Republic of China.

ABSTRACT

Background: Although dyslipidemia is related to the pathogenesis of renal insufficiency, which routinely available lipid measure is more applicable in estimation of kidney function is still uncertain. Our objective was to evaluate inconsistent associations of lipid profiles with both albuminuria and chronic kidney disease (CKD).

Methods: We performed a population-based study in 9730 subjects aged 40 years or older. Definitions of abnormalities in albumin excretion were according to the latest guidelines of American Diabetes Association's Standards of Medical Care. CKD was defined as estimated glomerular filtration rate (eGFR) < 60 mL/min per 1.73 m(2) or the presence of albuminuria.

Results: There were 2274 (23.4%) participants categorized as low-grade albuminuria, 639 (6.6%) participants categorized as increased urinary albumin excretion and 689 (7.1%) participants categorized as CKD. Triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), Non HDL-C to HDL-C ratio, TG to HDL-C ratio were significantly correlated with urinary albumin to creatinine ratio (ACR), serum creatinine and eGFR (all P < 0.0001). Compare with other lipid parameters, TG to HDL-C ratio have shown the strongest correlation with increased odds of both increased urinary albumin excretion and CKD. No significant associations between lipid parameters and low-grade albuminuria were observed after adjustments for potential confounding factors.

Conclusion: Our study lends support to discordant associations of lipid parameters with albuminuria and renal function. TG to HDL-C ratio is a better marker than other routine lipid measures for identifying renal insufficiency and should be given more consideration in the clinical practice.

Show MeSH
Related in: MedlinePlus