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Weight loss therapy for clinical management of patients with some atherosclerotic diseases: a randomized clinical trial.

Oshakbayev K, Dukenbayeva B, Otarbayev N, Togizbayeva G, Tabynbayev N, Gazaliyeva M, Idrisov A, Oshakbayev P - Nutr J (2015)

Bottom Line: A conception of AS was developed.The weight loss program treated the AS diseases; improved laboratory and instrumental parameters, decreased symptomatic drugs doses.AS development is a logical way of ontogenetic ageing of body fat.

View Article: PubMed Central - PubMed

Affiliation: Department of metabolic syndrome, National Medical Holding, Astana, Kazakhstan. okp.kuat@mail.ru.

ABSTRACT

Background: The prevalence and burden of atherosclerotic (AS) diseases are increasing during the last twenty years. Some studies show a close relationship between overweight and AS, but influence on AS diseases of different weight loss methods are still studying. The purpose of the research was to study the effectiveness of a weight loss program in AS patients in randomized controlled trial, and to develop a conception of evolution of AS.

Methods: A randomized controlled prospective clinical trial including 97 people, from them 71 patients with various AS manifestations. Patients were divided in 2 subgroups for non-drug weight loss program, and conventional drug therapy. The weight loss program included calorie restriction with 100-150 kcal/day, fat-free vegetables, salt diet, and optimum physical activity. Statistical analysis was performed using SPSS for Windows version 17.0.

Results: The weight loss subgroup lost ranging between 7-20% from an initial weight (P = 0.016). Weight loss was achieved due to fatty mass reduction only (P = 0.005). Hemoglobin levels (P < 0.001), bone mineral density (P < 0.001), percentages of water (P = 0.006) and muscle masses (P = 0.0038) were increased in weight loss subgroup. Ejection fraction (P < 0.0001), systolic output (P < 0.0001) were increased in patients with coronary artery disease. The weight loss program led to a decrease in symptomatic drugs doses up to total abolition. A conception of AS was developed.

Conclusions: The weight loss program treated the AS diseases; improved laboratory and instrumental parameters, decreased symptomatic drugs doses. AS development is a logical way of ontogenetic ageing of body fat.

Trial international registration: ClinicalTrials.gov NCT01700075.

Trial national registration: State registration is # 0109RK000079, code is O.0475 at the National Center for Scientific and Technical Information of the Republic of Kazakhstan.

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The conception of ontogenetic evolution of Atherosclerosis because of ageing of body fat. Abbreviations: DM, diabetes mellitus; HI, hyperinsulinemia; IFT, Impaired fat tolerance; IGT, Impaired glucose tolerance; IR, insulin resistance
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Fig3: The conception of ontogenetic evolution of Atherosclerosis because of ageing of body fat. Abbreviations: DM, diabetes mellitus; HI, hyperinsulinemia; IFT, Impaired fat tolerance; IGT, Impaired glucose tolerance; IR, insulin resistance

Mentions: As represented in the Fig. 3 the schematic conception of evolution of AS is related to the ontogenetic ageing of the body fat. The main chain of the suggested conception is: Overnutrition = > Overweight = > Limit of deposition = > Compensatory hyperinsulinemia = > Endogen metabolic intoxication = > Activation of protective mechanisms = > Sealing fat and Ageing fat = > AS processes. Adipose tissue in patients with overweight absorbs of organic metabolic pollutants. Compensatory hyperinsulinemia leads to metabolic abnormality (impaired glucose and fat tolerances, dyslipidemia, etc.). Metabolites overload of the blood transport system and lead to endogen metabolic intoxication. Activation of protective mechanisms (hypertension, hyperthermia, inflammation, allergic, etc.) against of further deposition of fat is images of chronic AS diseases. Long term storing fat in the body leads to ageing of the fat.Fig. 3


Weight loss therapy for clinical management of patients with some atherosclerotic diseases: a randomized clinical trial.

Oshakbayev K, Dukenbayeva B, Otarbayev N, Togizbayeva G, Tabynbayev N, Gazaliyeva M, Idrisov A, Oshakbayev P - Nutr J (2015)

The conception of ontogenetic evolution of Atherosclerosis because of ageing of body fat. Abbreviations: DM, diabetes mellitus; HI, hyperinsulinemia; IFT, Impaired fat tolerance; IGT, Impaired glucose tolerance; IR, insulin resistance
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4660604&req=5

Fig3: The conception of ontogenetic evolution of Atherosclerosis because of ageing of body fat. Abbreviations: DM, diabetes mellitus; HI, hyperinsulinemia; IFT, Impaired fat tolerance; IGT, Impaired glucose tolerance; IR, insulin resistance
Mentions: As represented in the Fig. 3 the schematic conception of evolution of AS is related to the ontogenetic ageing of the body fat. The main chain of the suggested conception is: Overnutrition = > Overweight = > Limit of deposition = > Compensatory hyperinsulinemia = > Endogen metabolic intoxication = > Activation of protective mechanisms = > Sealing fat and Ageing fat = > AS processes. Adipose tissue in patients with overweight absorbs of organic metabolic pollutants. Compensatory hyperinsulinemia leads to metabolic abnormality (impaired glucose and fat tolerances, dyslipidemia, etc.). Metabolites overload of the blood transport system and lead to endogen metabolic intoxication. Activation of protective mechanisms (hypertension, hyperthermia, inflammation, allergic, etc.) against of further deposition of fat is images of chronic AS diseases. Long term storing fat in the body leads to ageing of the fat.Fig. 3

Bottom Line: A conception of AS was developed.The weight loss program treated the AS diseases; improved laboratory and instrumental parameters, decreased symptomatic drugs doses.AS development is a logical way of ontogenetic ageing of body fat.

View Article: PubMed Central - PubMed

Affiliation: Department of metabolic syndrome, National Medical Holding, Astana, Kazakhstan. okp.kuat@mail.ru.

ABSTRACT

Background: The prevalence and burden of atherosclerotic (AS) diseases are increasing during the last twenty years. Some studies show a close relationship between overweight and AS, but influence on AS diseases of different weight loss methods are still studying. The purpose of the research was to study the effectiveness of a weight loss program in AS patients in randomized controlled trial, and to develop a conception of evolution of AS.

Methods: A randomized controlled prospective clinical trial including 97 people, from them 71 patients with various AS manifestations. Patients were divided in 2 subgroups for non-drug weight loss program, and conventional drug therapy. The weight loss program included calorie restriction with 100-150 kcal/day, fat-free vegetables, salt diet, and optimum physical activity. Statistical analysis was performed using SPSS for Windows version 17.0.

Results: The weight loss subgroup lost ranging between 7-20% from an initial weight (P = 0.016). Weight loss was achieved due to fatty mass reduction only (P = 0.005). Hemoglobin levels (P < 0.001), bone mineral density (P < 0.001), percentages of water (P = 0.006) and muscle masses (P = 0.0038) were increased in weight loss subgroup. Ejection fraction (P < 0.0001), systolic output (P < 0.0001) were increased in patients with coronary artery disease. The weight loss program led to a decrease in symptomatic drugs doses up to total abolition. A conception of AS was developed.

Conclusions: The weight loss program treated the AS diseases; improved laboratory and instrumental parameters, decreased symptomatic drugs doses. AS development is a logical way of ontogenetic ageing of body fat.

Trial international registration: ClinicalTrials.gov NCT01700075.

Trial national registration: State registration is # 0109RK000079, code is O.0475 at the National Center for Scientific and Technical Information of the Republic of Kazakhstan.

Show MeSH
Related in: MedlinePlus