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Bowenoid papulosis.

Nayak SU, Shenoi SD, Bhat ST, Shivamurthy A - Indian J Sex Transm Dis (2015 Jul-Dec)

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.

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We describe a case with lesions on the pubic area and penis... Multiple hyperpigmented papules, some verrucous, were present over the pubic region and shaft of penis Figure 1... BP was first described by Lloyd but described as an entity by Kopf et al Although HPV 16 is considered as the causative agent other HPV serotypes such as 18, 31, 33, 39, and 52 have also been implicated of which 16, 18, and 33 are the most oncogenic strains... Lesions should be differentiated from genital warts, lichen planus, molluscum contagiosum, seborrheic keratosis, and Bowen's disease... BP is considered as a transitional stage between genital warts and squamous carcinoma in situ... The classical histopathological features include full thickness epidermal atypia, loss of architecture, intact basement membrane with koilocytotic, dyskeratotic cells, and metaphase mitoses... The natural history of the disease is not well known... It usually runs a long course but spontaneously resolves... Transformation to invasive carcinoma is rare occurring in <1% of cases, especially in immunocompromised... Treatment should be conservative using modalities such as electrofulguration, cryotherapy, scissors excision, topical application of 5-fluoruracil or 5% imiquimod, intralesional recombinant alpha - 2 interferon, photodynamic therapy, and CO2 laser vaporization... There are no conflicts of interest.

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Bowenoid papulosis on the genitalia
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Figure 1: Bowenoid papulosis on the genitalia

Mentions: A 41-year-old male presented with asymptomatic lesions over the pubic region for past 8-10 months. He was married for the past 15 years with a history of single unprotected premarital sexual contact with a known person. Multiple hyperpigmented papules, some verrucous, were present over the pubic region and shaft of penis Figure 1. A diagnosis of BP was considered. Biopsy of the papule showed acanthotic epidermis Figure 2 and mild dysplastic features with anisonucleosis, nuclear enlargement, and increased mitosis [Figure 3] with mild dermal perivascular infiltrate. DNA-polymerase chain reaction (PCR) markers for HPV strains 16 and 18 were negative. The patient was treated with 5% imiquimod cream.


Bowenoid papulosis.

Nayak SU, Shenoi SD, Bhat ST, Shivamurthy A - Indian J Sex Transm Dis (2015 Jul-Dec)

Bowenoid papulosis on the genitalia
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4660577&req=5

Figure 1: Bowenoid papulosis on the genitalia
Mentions: A 41-year-old male presented with asymptomatic lesions over the pubic region for past 8-10 months. He was married for the past 15 years with a history of single unprotected premarital sexual contact with a known person. Multiple hyperpigmented papules, some verrucous, were present over the pubic region and shaft of penis Figure 1. A diagnosis of BP was considered. Biopsy of the papule showed acanthotic epidermis Figure 2 and mild dysplastic features with anisonucleosis, nuclear enlargement, and increased mitosis [Figure 3] with mild dermal perivascular infiltrate. DNA-polymerase chain reaction (PCR) markers for HPV strains 16 and 18 were negative. The patient was treated with 5% imiquimod cream.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

We describe a case with lesions on the pubic area and penis... Multiple hyperpigmented papules, some verrucous, were present over the pubic region and shaft of penis Figure 1... BP was first described by Lloyd but described as an entity by Kopf et al Although HPV 16 is considered as the causative agent other HPV serotypes such as 18, 31, 33, 39, and 52 have also been implicated of which 16, 18, and 33 are the most oncogenic strains... Lesions should be differentiated from genital warts, lichen planus, molluscum contagiosum, seborrheic keratosis, and Bowen's disease... BP is considered as a transitional stage between genital warts and squamous carcinoma in situ... The classical histopathological features include full thickness epidermal atypia, loss of architecture, intact basement membrane with koilocytotic, dyskeratotic cells, and metaphase mitoses... The natural history of the disease is not well known... It usually runs a long course but spontaneously resolves... Transformation to invasive carcinoma is rare occurring in <1% of cases, especially in immunocompromised... Treatment should be conservative using modalities such as electrofulguration, cryotherapy, scissors excision, topical application of 5-fluoruracil or 5% imiquimod, intralesional recombinant alpha - 2 interferon, photodynamic therapy, and CO2 laser vaporization... There are no conflicts of interest.

No MeSH data available.


Related in: MedlinePlus