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Anti-inflammatory and anti-arthritic activity of a methanol extract from Vitellaria paradoxa stem bark.

Foyet HS, Tsala DE, Zogo Essono Bodo JC, Carine AN, Heroyne LT, Oben EK - Pharmacognosy Res (2014 Oct-Dec)

Bottom Line: The effects on hyperalgesia and locomotors activity were also quantified.On the complete Freund's adjuvant-induced rheumatoid arthritis, VPME showed a significant protective effect with 8.12% inflammation against 25.00% for the control group after 2 days of the treatment.The extract (75 and 150 mg/kg) significantly reduced the score of arthritis with a maximum obtained on day 19(th) of the experimentation.

View Article: PubMed Central - PubMed

Affiliation: Department of Biological Sciences, Faculty of Sciences, University of Maroua, P.O Box 814, Cameroon.

ABSTRACT

Background: Vitellaria paradoxa is a traditional medicinal plant of Cameroon. Several studies on this plant have focused on the cosmetic profile of its fruits. The present study focuses on the anti-inflammatory potency of stem barks extract of this plant.

Objective: The objective was to evaluate the effect of methanolic extract of V. paradoxa (VPME) stem barks on inflammatory response in rats.

Materials and methods: Anti-inflammatory effects of VPME were evaluated in acute and chronic (28 days) inflammation induced in Wistar albino rats. The effects on hyperalgesia and locomotors activity were also quantified. The relative weight of lymphoid organs was obtained as well as some hematological parameters.

Results: In the carrageenan-induced inflammation, VPME (75 mg/kg) exhibited a significant (66.67%) inhibition after 1 h. On the complete Freund's adjuvant-induced rheumatoid arthritis, VPME showed a significant protective effect with 8.12% inflammation against 25.00% for the control group after 2 days of the treatment. The extract (75 and 150 mg/kg) significantly reduced the score of arthritis with a maximum obtained on day 19(th) of the experimentation. There was a significant increase in the reaction time of rats on the hot plate as well as the exploratory activities of the animals in the open field. This extract significantly prevented weight, hemoglobin and red blood cells losses, and spleen hypertrophy. A protective action against skin destruction and cartilage erosion was evident. Liquid chromatography-mass spectrometry analysis of the extract revealed the presence of catechins.

Conclusions: These findings suggested that V. paradoxa may contribute to the reduction of the inflammatory response.

No MeSH data available.


Related in: MedlinePlus

Effect of methanol extract of Vitellaria paradoxa oral administration on white blood cell, hemoglobin, and hematocrit. Data are presented as mean ± ESM (n = 4). *P < 0.05; **P < 0.01; ***P < 0.001 versus control; #P < 0.05; versus normal
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Figure 8: Effect of methanol extract of Vitellaria paradoxa oral administration on white blood cell, hemoglobin, and hematocrit. Data are presented as mean ± ESM (n = 4). *P < 0.05; **P < 0.01; ***P < 0.001 versus control; #P < 0.05; versus normal

Mentions: At the end of the study, there was significant increase (P < 0.05) in the total WBC, and significant decrease (P < 0.05) along the Hb and hematocrit level of control animals as compared to normal rats. However, the treatment with VPME (150 and 300 mg/kg) showed a significant increase in the Hb (P < 0.001) and hematocrit (P < 0.05) when compared to control group. At the same time, the VPME (150 and 300 mg/kg) significantly attenuated the increase of WBC level and at the end, their values were close to that of normal animals [Figure 8]. The effect of diclofenac on the WBC level was not significant.


Anti-inflammatory and anti-arthritic activity of a methanol extract from Vitellaria paradoxa stem bark.

Foyet HS, Tsala DE, Zogo Essono Bodo JC, Carine AN, Heroyne LT, Oben EK - Pharmacognosy Res (2014 Oct-Dec)

Effect of methanol extract of Vitellaria paradoxa oral administration on white blood cell, hemoglobin, and hematocrit. Data are presented as mean ± ESM (n = 4). *P < 0.05; **P < 0.01; ***P < 0.001 versus control; #P < 0.05; versus normal
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4660517&req=5

Figure 8: Effect of methanol extract of Vitellaria paradoxa oral administration on white blood cell, hemoglobin, and hematocrit. Data are presented as mean ± ESM (n = 4). *P < 0.05; **P < 0.01; ***P < 0.001 versus control; #P < 0.05; versus normal
Mentions: At the end of the study, there was significant increase (P < 0.05) in the total WBC, and significant decrease (P < 0.05) along the Hb and hematocrit level of control animals as compared to normal rats. However, the treatment with VPME (150 and 300 mg/kg) showed a significant increase in the Hb (P < 0.001) and hematocrit (P < 0.05) when compared to control group. At the same time, the VPME (150 and 300 mg/kg) significantly attenuated the increase of WBC level and at the end, their values were close to that of normal animals [Figure 8]. The effect of diclofenac on the WBC level was not significant.

Bottom Line: The effects on hyperalgesia and locomotors activity were also quantified.On the complete Freund's adjuvant-induced rheumatoid arthritis, VPME showed a significant protective effect with 8.12% inflammation against 25.00% for the control group after 2 days of the treatment.The extract (75 and 150 mg/kg) significantly reduced the score of arthritis with a maximum obtained on day 19(th) of the experimentation.

View Article: PubMed Central - PubMed

Affiliation: Department of Biological Sciences, Faculty of Sciences, University of Maroua, P.O Box 814, Cameroon.

ABSTRACT

Background: Vitellaria paradoxa is a traditional medicinal plant of Cameroon. Several studies on this plant have focused on the cosmetic profile of its fruits. The present study focuses on the anti-inflammatory potency of stem barks extract of this plant.

Objective: The objective was to evaluate the effect of methanolic extract of V. paradoxa (VPME) stem barks on inflammatory response in rats.

Materials and methods: Anti-inflammatory effects of VPME were evaluated in acute and chronic (28 days) inflammation induced in Wistar albino rats. The effects on hyperalgesia and locomotors activity were also quantified. The relative weight of lymphoid organs was obtained as well as some hematological parameters.

Results: In the carrageenan-induced inflammation, VPME (75 mg/kg) exhibited a significant (66.67%) inhibition after 1 h. On the complete Freund's adjuvant-induced rheumatoid arthritis, VPME showed a significant protective effect with 8.12% inflammation against 25.00% for the control group after 2 days of the treatment. The extract (75 and 150 mg/kg) significantly reduced the score of arthritis with a maximum obtained on day 19(th) of the experimentation. There was a significant increase in the reaction time of rats on the hot plate as well as the exploratory activities of the animals in the open field. This extract significantly prevented weight, hemoglobin and red blood cells losses, and spleen hypertrophy. A protective action against skin destruction and cartilage erosion was evident. Liquid chromatography-mass spectrometry analysis of the extract revealed the presence of catechins.

Conclusions: These findings suggested that V. paradoxa may contribute to the reduction of the inflammatory response.

No MeSH data available.


Related in: MedlinePlus