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Anti-inflammatory and anti-arthritic activity of a methanol extract from Vitellaria paradoxa stem bark.

Foyet HS, Tsala DE, Zogo Essono Bodo JC, Carine AN, Heroyne LT, Oben EK - Pharmacognosy Res (2014 Oct-Dec)

Bottom Line: The effects on hyperalgesia and locomotors activity were also quantified.On the complete Freund's adjuvant-induced rheumatoid arthritis, VPME showed a significant protective effect with 8.12% inflammation against 25.00% for the control group after 2 days of the treatment.The extract (75 and 150 mg/kg) significantly reduced the score of arthritis with a maximum obtained on day 19(th) of the experimentation.

View Article: PubMed Central - PubMed

Affiliation: Department of Biological Sciences, Faculty of Sciences, University of Maroua, P.O Box 814, Cameroon.

ABSTRACT

Background: Vitellaria paradoxa is a traditional medicinal plant of Cameroon. Several studies on this plant have focused on the cosmetic profile of its fruits. The present study focuses on the anti-inflammatory potency of stem barks extract of this plant.

Objective: The objective was to evaluate the effect of methanolic extract of V. paradoxa (VPME) stem barks on inflammatory response in rats.

Materials and methods: Anti-inflammatory effects of VPME were evaluated in acute and chronic (28 days) inflammation induced in Wistar albino rats. The effects on hyperalgesia and locomotors activity were also quantified. The relative weight of lymphoid organs was obtained as well as some hematological parameters.

Results: In the carrageenan-induced inflammation, VPME (75 mg/kg) exhibited a significant (66.67%) inhibition after 1 h. On the complete Freund's adjuvant-induced rheumatoid arthritis, VPME showed a significant protective effect with 8.12% inflammation against 25.00% for the control group after 2 days of the treatment. The extract (75 and 150 mg/kg) significantly reduced the score of arthritis with a maximum obtained on day 19(th) of the experimentation. There was a significant increase in the reaction time of rats on the hot plate as well as the exploratory activities of the animals in the open field. This extract significantly prevented weight, hemoglobin and red blood cells losses, and spleen hypertrophy. A protective action against skin destruction and cartilage erosion was evident. Liquid chromatography-mass spectrometry analysis of the extract revealed the presence of catechins.

Conclusions: These findings suggested that V. paradoxa may contribute to the reduction of the inflammatory response.

No MeSH data available.


Related in: MedlinePlus

Effect of oral administration of methanol extract of Vitellaria paradoxa on the arthritic score. Data represent mean ± standard error of the mean of five animals. *P < 0.05, **P < 0.01 as compared to control group animals and ###P < 0.001 as compared to normal animals
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Figure 4: Effect of oral administration of methanol extract of Vitellaria paradoxa on the arthritic score. Data represent mean ± standard error of the mean of five animals. *P < 0.05, **P < 0.01 as compared to control group animals and ###P < 0.001 as compared to normal animals

Mentions: Subplantar administration of CFA results in significant increased (P < 0.001) in arthritic score in all CFA treated rats as compared to normal rats. There was a decrease in the arthritic score from day 4 to 10, however, this change was not significant. The arthritic score of the control group remained high till the end of the experiment, that is, up to the 28th day as compared to normal rats. Rats treated with VPME (150 mg/kg) showed significant decreased in arthritic score from day 14 to day 21 (P < 0.05) and from day 24 onward till the end of the study (P < 0.01) as compared to control rats [Figure 4].


Anti-inflammatory and anti-arthritic activity of a methanol extract from Vitellaria paradoxa stem bark.

Foyet HS, Tsala DE, Zogo Essono Bodo JC, Carine AN, Heroyne LT, Oben EK - Pharmacognosy Res (2014 Oct-Dec)

Effect of oral administration of methanol extract of Vitellaria paradoxa on the arthritic score. Data represent mean ± standard error of the mean of five animals. *P < 0.05, **P < 0.01 as compared to control group animals and ###P < 0.001 as compared to normal animals
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4660517&req=5

Figure 4: Effect of oral administration of methanol extract of Vitellaria paradoxa on the arthritic score. Data represent mean ± standard error of the mean of five animals. *P < 0.05, **P < 0.01 as compared to control group animals and ###P < 0.001 as compared to normal animals
Mentions: Subplantar administration of CFA results in significant increased (P < 0.001) in arthritic score in all CFA treated rats as compared to normal rats. There was a decrease in the arthritic score from day 4 to 10, however, this change was not significant. The arthritic score of the control group remained high till the end of the experiment, that is, up to the 28th day as compared to normal rats. Rats treated with VPME (150 mg/kg) showed significant decreased in arthritic score from day 14 to day 21 (P < 0.05) and from day 24 onward till the end of the study (P < 0.01) as compared to control rats [Figure 4].

Bottom Line: The effects on hyperalgesia and locomotors activity were also quantified.On the complete Freund's adjuvant-induced rheumatoid arthritis, VPME showed a significant protective effect with 8.12% inflammation against 25.00% for the control group after 2 days of the treatment.The extract (75 and 150 mg/kg) significantly reduced the score of arthritis with a maximum obtained on day 19(th) of the experimentation.

View Article: PubMed Central - PubMed

Affiliation: Department of Biological Sciences, Faculty of Sciences, University of Maroua, P.O Box 814, Cameroon.

ABSTRACT

Background: Vitellaria paradoxa is a traditional medicinal plant of Cameroon. Several studies on this plant have focused on the cosmetic profile of its fruits. The present study focuses on the anti-inflammatory potency of stem barks extract of this plant.

Objective: The objective was to evaluate the effect of methanolic extract of V. paradoxa (VPME) stem barks on inflammatory response in rats.

Materials and methods: Anti-inflammatory effects of VPME were evaluated in acute and chronic (28 days) inflammation induced in Wistar albino rats. The effects on hyperalgesia and locomotors activity were also quantified. The relative weight of lymphoid organs was obtained as well as some hematological parameters.

Results: In the carrageenan-induced inflammation, VPME (75 mg/kg) exhibited a significant (66.67%) inhibition after 1 h. On the complete Freund's adjuvant-induced rheumatoid arthritis, VPME showed a significant protective effect with 8.12% inflammation against 25.00% for the control group after 2 days of the treatment. The extract (75 and 150 mg/kg) significantly reduced the score of arthritis with a maximum obtained on day 19(th) of the experimentation. There was a significant increase in the reaction time of rats on the hot plate as well as the exploratory activities of the animals in the open field. This extract significantly prevented weight, hemoglobin and red blood cells losses, and spleen hypertrophy. A protective action against skin destruction and cartilage erosion was evident. Liquid chromatography-mass spectrometry analysis of the extract revealed the presence of catechins.

Conclusions: These findings suggested that V. paradoxa may contribute to the reduction of the inflammatory response.

No MeSH data available.


Related in: MedlinePlus