Limits...
Anti-inflammatory and anti-arthritic activity of a methanol extract from Vitellaria paradoxa stem bark.

Foyet HS, Tsala DE, Zogo Essono Bodo JC, Carine AN, Heroyne LT, Oben EK - Pharmacognosy Res (2014 Oct-Dec)

Bottom Line: The effects on hyperalgesia and locomotors activity were also quantified.On the complete Freund's adjuvant-induced rheumatoid arthritis, VPME showed a significant protective effect with 8.12% inflammation against 25.00% for the control group after 2 days of the treatment.The extract (75 and 150 mg/kg) significantly reduced the score of arthritis with a maximum obtained on day 19(th) of the experimentation.

View Article: PubMed Central - PubMed

Affiliation: Department of Biological Sciences, Faculty of Sciences, University of Maroua, P.O Box 814, Cameroon.

ABSTRACT

Background: Vitellaria paradoxa is a traditional medicinal plant of Cameroon. Several studies on this plant have focused on the cosmetic profile of its fruits. The present study focuses on the anti-inflammatory potency of stem barks extract of this plant.

Objective: The objective was to evaluate the effect of methanolic extract of V. paradoxa (VPME) stem barks on inflammatory response in rats.

Materials and methods: Anti-inflammatory effects of VPME were evaluated in acute and chronic (28 days) inflammation induced in Wistar albino rats. The effects on hyperalgesia and locomotors activity were also quantified. The relative weight of lymphoid organs was obtained as well as some hematological parameters.

Results: In the carrageenan-induced inflammation, VPME (75 mg/kg) exhibited a significant (66.67%) inhibition after 1 h. On the complete Freund's adjuvant-induced rheumatoid arthritis, VPME showed a significant protective effect with 8.12% inflammation against 25.00% for the control group after 2 days of the treatment. The extract (75 and 150 mg/kg) significantly reduced the score of arthritis with a maximum obtained on day 19(th) of the experimentation. There was a significant increase in the reaction time of rats on the hot plate as well as the exploratory activities of the animals in the open field. This extract significantly prevented weight, hemoglobin and red blood cells losses, and spleen hypertrophy. A protective action against skin destruction and cartilage erosion was evident. Liquid chromatography-mass spectrometry analysis of the extract revealed the presence of catechins.

Conclusions: These findings suggested that V. paradoxa may contribute to the reduction of the inflammatory response.

No MeSH data available.


Related in: MedlinePlus

Effect of methanol extract of Vitellaria paradoxa oral administration on joint diameter. Data represent mean of five animals. *P < 0.05, **P < 0.01 as compared to control group animals
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4660517&req=5

Figure 3: Effect of methanol extract of Vitellaria paradoxa oral administration on joint diameter. Data represent mean of five animals. *P < 0.05, **P < 0.01 as compared to control group animals

Mentions: Two days after, the beginning of treatment, VPME (75 and 150 mg/kg) treated groups exhibited remarkable and significant (P 0˂ 0.05) decline in the joint diameter when compared to that of control arthritic group while diclofenac-treated animals showed a significant (P ˂ 0.05) result some days later (24 days) [Figure 3].


Anti-inflammatory and anti-arthritic activity of a methanol extract from Vitellaria paradoxa stem bark.

Foyet HS, Tsala DE, Zogo Essono Bodo JC, Carine AN, Heroyne LT, Oben EK - Pharmacognosy Res (2014 Oct-Dec)

Effect of methanol extract of Vitellaria paradoxa oral administration on joint diameter. Data represent mean of five animals. *P < 0.05, **P < 0.01 as compared to control group animals
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4660517&req=5

Figure 3: Effect of methanol extract of Vitellaria paradoxa oral administration on joint diameter. Data represent mean of five animals. *P < 0.05, **P < 0.01 as compared to control group animals
Mentions: Two days after, the beginning of treatment, VPME (75 and 150 mg/kg) treated groups exhibited remarkable and significant (P 0˂ 0.05) decline in the joint diameter when compared to that of control arthritic group while diclofenac-treated animals showed a significant (P ˂ 0.05) result some days later (24 days) [Figure 3].

Bottom Line: The effects on hyperalgesia and locomotors activity were also quantified.On the complete Freund's adjuvant-induced rheumatoid arthritis, VPME showed a significant protective effect with 8.12% inflammation against 25.00% for the control group after 2 days of the treatment.The extract (75 and 150 mg/kg) significantly reduced the score of arthritis with a maximum obtained on day 19(th) of the experimentation.

View Article: PubMed Central - PubMed

Affiliation: Department of Biological Sciences, Faculty of Sciences, University of Maroua, P.O Box 814, Cameroon.

ABSTRACT

Background: Vitellaria paradoxa is a traditional medicinal plant of Cameroon. Several studies on this plant have focused on the cosmetic profile of its fruits. The present study focuses on the anti-inflammatory potency of stem barks extract of this plant.

Objective: The objective was to evaluate the effect of methanolic extract of V. paradoxa (VPME) stem barks on inflammatory response in rats.

Materials and methods: Anti-inflammatory effects of VPME were evaluated in acute and chronic (28 days) inflammation induced in Wistar albino rats. The effects on hyperalgesia and locomotors activity were also quantified. The relative weight of lymphoid organs was obtained as well as some hematological parameters.

Results: In the carrageenan-induced inflammation, VPME (75 mg/kg) exhibited a significant (66.67%) inhibition after 1 h. On the complete Freund's adjuvant-induced rheumatoid arthritis, VPME showed a significant protective effect with 8.12% inflammation against 25.00% for the control group after 2 days of the treatment. The extract (75 and 150 mg/kg) significantly reduced the score of arthritis with a maximum obtained on day 19(th) of the experimentation. There was a significant increase in the reaction time of rats on the hot plate as well as the exploratory activities of the animals in the open field. This extract significantly prevented weight, hemoglobin and red blood cells losses, and spleen hypertrophy. A protective action against skin destruction and cartilage erosion was evident. Liquid chromatography-mass spectrometry analysis of the extract revealed the presence of catechins.

Conclusions: These findings suggested that V. paradoxa may contribute to the reduction of the inflammatory response.

No MeSH data available.


Related in: MedlinePlus