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A New Antimicrobial Prenylated Benzo-lactone from the Rhizome of Cissus cornifolia.

Musa AM, Tajuddeen N, Idris AY, Rafindadi AY, Abdullahi MI, Aliyu AB, Abdullahi MS, Ibrahim MA - Pharmacognosy Res (2014 Oct-Dec)

Bottom Line: The inhibition zones ranged between 17 mm and 25 mm.The compound could serve as a lead for the development of more potent antimicrobial agent.To the best of our knowledge, this is the first report of the isolation and characterization as well as antimicrobial screening of the compound.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutical and Medicinal Chemistry, Zaria, Nigeria.

ABSTRACT

Background: Medicinal plants remain one of the largest reservoirs of new bioactive compounds. In this study, a new prenylated benzo-lactone (4, 6-dihydroxy-5-methoxy-3-(1, 2, 3, 4, 5-pentahydroxypentyl)-2-benzofuran-1(3H)-one) was isolated from the acetone extracts of the rhizome of Cissus cornifolia. The antimicrobial activity of the compound was evaluated against some microorganisms including Staphylococcus aureus, Salmonella typhi, and Candida albicans.

Materials and methods: The acetone extracts of the rhizome of C. cornifolia was separated and purified by various chromatographic techniques. The structure of the isolated compound was characterized by analysis of spectral data including one and two-dimensional nuclear magnetic resonance.

Results: The isolated compound was characterized as (4, 6-dihydroxy-5-methoxy-3-(1, 2, 3, 4, 5-pentahydroxypentyl)-2-benzofuran-1(3H)-one), it showed activity against 6 out of 10 tested clinical isolates of some microorganisms including S. aureus, S. typhi, and C. albicans. The inhibition zones ranged between 17 mm and 25 mm. The inhibition zones observed compare favorably with the positive control used.

Conclusion: The compound could serve as a lead for the development of more potent antimicrobial agent. To the best of our knowledge, this is the first report of the isolation and characterization as well as antimicrobial screening of the compound.

No MeSH data available.


Related in: MedlinePlus

4, 6-dihydroxy-5-methoxy-3-(1, 2, 3, 4, 5-pentahydroxy-pentyl)-2-benzofuran-1-(3H)-one
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Figure 2: 4, 6-dihydroxy-5-methoxy-3-(1, 2, 3, 4, 5-pentahydroxy-pentyl)-2-benzofuran-1-(3H)-one

Mentions: Based on these spectroscopic evidences, the structure of 1 [Figure 2] was elucidated as 4, 6-dihydroxy-5-methoxy-3-(1, 2, 3, 4, 5-pentahydroxypentyl)-2-benzofuran-1(3H)-one.


A New Antimicrobial Prenylated Benzo-lactone from the Rhizome of Cissus cornifolia.

Musa AM, Tajuddeen N, Idris AY, Rafindadi AY, Abdullahi MI, Aliyu AB, Abdullahi MS, Ibrahim MA - Pharmacognosy Res (2014 Oct-Dec)

4, 6-dihydroxy-5-methoxy-3-(1, 2, 3, 4, 5-pentahydroxy-pentyl)-2-benzofuran-1-(3H)-one
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4660516&req=5

Figure 2: 4, 6-dihydroxy-5-methoxy-3-(1, 2, 3, 4, 5-pentahydroxy-pentyl)-2-benzofuran-1-(3H)-one
Mentions: Based on these spectroscopic evidences, the structure of 1 [Figure 2] was elucidated as 4, 6-dihydroxy-5-methoxy-3-(1, 2, 3, 4, 5-pentahydroxypentyl)-2-benzofuran-1(3H)-one.

Bottom Line: The inhibition zones ranged between 17 mm and 25 mm.The compound could serve as a lead for the development of more potent antimicrobial agent.To the best of our knowledge, this is the first report of the isolation and characterization as well as antimicrobial screening of the compound.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutical and Medicinal Chemistry, Zaria, Nigeria.

ABSTRACT

Background: Medicinal plants remain one of the largest reservoirs of new bioactive compounds. In this study, a new prenylated benzo-lactone (4, 6-dihydroxy-5-methoxy-3-(1, 2, 3, 4, 5-pentahydroxypentyl)-2-benzofuran-1(3H)-one) was isolated from the acetone extracts of the rhizome of Cissus cornifolia. The antimicrobial activity of the compound was evaluated against some microorganisms including Staphylococcus aureus, Salmonella typhi, and Candida albicans.

Materials and methods: The acetone extracts of the rhizome of C. cornifolia was separated and purified by various chromatographic techniques. The structure of the isolated compound was characterized by analysis of spectral data including one and two-dimensional nuclear magnetic resonance.

Results: The isolated compound was characterized as (4, 6-dihydroxy-5-methoxy-3-(1, 2, 3, 4, 5-pentahydroxypentyl)-2-benzofuran-1(3H)-one), it showed activity against 6 out of 10 tested clinical isolates of some microorganisms including S. aureus, S. typhi, and C. albicans. The inhibition zones ranged between 17 mm and 25 mm. The inhibition zones observed compare favorably with the positive control used.

Conclusion: The compound could serve as a lead for the development of more potent antimicrobial agent. To the best of our knowledge, this is the first report of the isolation and characterization as well as antimicrobial screening of the compound.

No MeSH data available.


Related in: MedlinePlus