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Chemical constituents of Phragmanthera austroarabica A. G. Mill and J. A. Nyberg with potent antioxidant activity.

Badr JM - Pharmacognosy Res (2014 Oct-Dec)

Bottom Line: Phytochemical investigation of the plant resulted in isolation of 12 compounds.The isolated compounds were identified as chrysophanic acid, emodin, chrysophanic acid-8-O-glucoside, emodin-8-O-glucoside, pectolinarigenin, quercetin, dillenetin-3-O-glucoside, catechin, catechin-4'-O-gallate, methyl gallate, lupeol and ursolic acid.All the isolated phenolic compounds revealed significant free radical scavenging activities when tested using 2,2-diphenyl-1-picrylhydrazyl reagent.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt.

ABSTRACT

Background: Phragmanthera austroarabica A.G. Mill. and J. A. Nyberg is a semi parasitic plant belonging to family Loranthaceae. It was collected from Saudi Arabia. It is widely used in folk medicine among the kingdom in treatment of various diseases including diabetes mellitus.

Objective: The total alcoholic extract of P. austroarabica collected from Saudi Arabia was investigated for the chemical structure and prominent biological activity of the main constituents.

Materials and methods: Isolation of the active constituents was performed using different chromatographic techniques including column chromatography packed with silica or sephadex and preparative thin layer chromatography. The structures of the isolated compounds were established based on different spectroscopic data as mass spectrum, one-dimensional and two-dimensional nuclear magnetic resonance (correlation spectroscopy, heteronuclear single quantum coherence, and heteronuclear multiple-bond correlation).

Results: Phytochemical investigation of the plant resulted in isolation of 12 compounds. The isolated compounds were identified as chrysophanic acid, emodin, chrysophanic acid-8-O-glucoside, emodin-8-O-glucoside, pectolinarigenin, quercetin, dillenetin-3-O-glucoside, catechin, catechin-4'-O-gallate, methyl gallate, lupeol and ursolic acid. All the isolated phenolic compounds revealed significant free radical scavenging activities when tested using 2,2-diphenyl-1-picrylhydrazyl reagent.

Conclusion: The antioxidant activities of the isolated compounds can justify the use of P. austroarabica in traditional medicine for treatment of diabetes and verify its possible application as an antihyperglycemic drug.

No MeSH data available.


Related in: MedlinePlus

Structures of the isolated compounds
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Figure 1: Structures of the isolated compounds

Mentions: Family Loranthaceae comprises a number of the stem parasites that are commonly known as mistletoes. A number of mistletoes belonging to this family were investigated for chemical constituents and reported to accumulate flavonoids and phenolic compounds.[1234] Phragmanthera austroarabica; a plant belonging to family Loranthaceae was collected from Saudi Arabia. It is widely used in folk medicine among the kingdom in treatment of various diseases among them is diabetes mellitus.[56] Upon reviewing the literature, it was found that no previous reports on the chemical constituents of P. austroarabica. In the present work, the total extract of the plant was chemically investigated where 12 compounds were isolated and their structures were determined using different spectroscopic techniques [Figure 1]. Additionally, the pure isolated compounds were tested to evaluate their free radical scavenging activities using 2,2-diphenyl-1-picrylhydrazyl (DPPH) reagent.


Chemical constituents of Phragmanthera austroarabica A. G. Mill and J. A. Nyberg with potent antioxidant activity.

Badr JM - Pharmacognosy Res (2014 Oct-Dec)

Structures of the isolated compounds
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4660512&req=5

Figure 1: Structures of the isolated compounds
Mentions: Family Loranthaceae comprises a number of the stem parasites that are commonly known as mistletoes. A number of mistletoes belonging to this family were investigated for chemical constituents and reported to accumulate flavonoids and phenolic compounds.[1234] Phragmanthera austroarabica; a plant belonging to family Loranthaceae was collected from Saudi Arabia. It is widely used in folk medicine among the kingdom in treatment of various diseases among them is diabetes mellitus.[56] Upon reviewing the literature, it was found that no previous reports on the chemical constituents of P. austroarabica. In the present work, the total extract of the plant was chemically investigated where 12 compounds were isolated and their structures were determined using different spectroscopic techniques [Figure 1]. Additionally, the pure isolated compounds were tested to evaluate their free radical scavenging activities using 2,2-diphenyl-1-picrylhydrazyl (DPPH) reagent.

Bottom Line: Phytochemical investigation of the plant resulted in isolation of 12 compounds.The isolated compounds were identified as chrysophanic acid, emodin, chrysophanic acid-8-O-glucoside, emodin-8-O-glucoside, pectolinarigenin, quercetin, dillenetin-3-O-glucoside, catechin, catechin-4'-O-gallate, methyl gallate, lupeol and ursolic acid.All the isolated phenolic compounds revealed significant free radical scavenging activities when tested using 2,2-diphenyl-1-picrylhydrazyl reagent.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt.

ABSTRACT

Background: Phragmanthera austroarabica A.G. Mill. and J. A. Nyberg is a semi parasitic plant belonging to family Loranthaceae. It was collected from Saudi Arabia. It is widely used in folk medicine among the kingdom in treatment of various diseases including diabetes mellitus.

Objective: The total alcoholic extract of P. austroarabica collected from Saudi Arabia was investigated for the chemical structure and prominent biological activity of the main constituents.

Materials and methods: Isolation of the active constituents was performed using different chromatographic techniques including column chromatography packed with silica or sephadex and preparative thin layer chromatography. The structures of the isolated compounds were established based on different spectroscopic data as mass spectrum, one-dimensional and two-dimensional nuclear magnetic resonance (correlation spectroscopy, heteronuclear single quantum coherence, and heteronuclear multiple-bond correlation).

Results: Phytochemical investigation of the plant resulted in isolation of 12 compounds. The isolated compounds were identified as chrysophanic acid, emodin, chrysophanic acid-8-O-glucoside, emodin-8-O-glucoside, pectolinarigenin, quercetin, dillenetin-3-O-glucoside, catechin, catechin-4'-O-gallate, methyl gallate, lupeol and ursolic acid. All the isolated phenolic compounds revealed significant free radical scavenging activities when tested using 2,2-diphenyl-1-picrylhydrazyl reagent.

Conclusion: The antioxidant activities of the isolated compounds can justify the use of P. austroarabica in traditional medicine for treatment of diabetes and verify its possible application as an antihyperglycemic drug.

No MeSH data available.


Related in: MedlinePlus