Limits...
PROTECTIVE LEVELS OF VARICELLA-ZOSTER ANTIBODY DID NOT EFFECTIVELY PREVENT CHICKENPOX IN AN X-LINKED AGAMMAGLOBULINEMIA PATIENT.

Nobre FA, Gonzalez IG, de Moraes-Pinto MI, Costa-Carvalho BT - Rev. Inst. Med. Trop. Sao Paulo (2015 Sep-Oct)

Bottom Line: We describe the case of an eight-year-old boy with X-linked agammaglobulinemia who developed mild varicella despite regular intravenous immunoglobulin (IVIG) therapy.He maintained protective antibody levels against varicella and the previous batches of IVIG that he received had adequate varicella-specific IgG levels.The case illustrates that IVIG may not prevent VZV infection.

View Article: PubMed Central - PubMed

Affiliation: Departmento de Pediatria, Universidade Federal de São Paulo, São Paulo, SP, Brasil, aimeenobre@yahoo.com.br; belinhagonzalez@hotmail.com; m.isabelmp@uol.com.br; beacarvalho@terra.com.br.

ABSTRACT
We describe the case of an eight-year-old boy with X-linked agammaglobulinemia who developed mild varicella despite regular intravenous immunoglobulin (IVIG) therapy. He maintained protective antibody levels against varicella and the previous batches of IVIG that he received had adequate varicella-specific IgG levels. The case illustrates that IVIG may not prevent VZV infection.

Show MeSH

Related in: MedlinePlus

- CD25 expression on CD4+ and CD8+ T lymphocytes after incubation with VZV specific antigens. The final value of positive cells was obtained by subtracting the percentage of cells stimulated with cell supernatant of non-VZV-infected cells (negative control) from the percentage of cells from the culture in presence of the stimulus (VZV antigen). Adapted from VIANA et al., 201018.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4660460&req=5

f01: - CD25 expression on CD4+ and CD8+ T lymphocytes after incubation with VZV specific antigens. The final value of positive cells was obtained by subtracting the percentage of cells stimulated with cell supernatant of non-VZV-infected cells (negative control) from the percentage of cells from the culture in presence of the stimulus (VZV antigen). Adapted from VIANA et al., 201018.

Mentions: At the time of varicella infection, the patient's CD4+ and CD8+ T lymphocyte counts were 2388 cells/mm3 and 1293 cells/mm3, respectively. Fifteen days after infection, both CD4+ and CD8+ T cells expressed CD25 upon in vitro stimulation with VZV specific antigens18 (Fig. 1).


PROTECTIVE LEVELS OF VARICELLA-ZOSTER ANTIBODY DID NOT EFFECTIVELY PREVENT CHICKENPOX IN AN X-LINKED AGAMMAGLOBULINEMIA PATIENT.

Nobre FA, Gonzalez IG, de Moraes-Pinto MI, Costa-Carvalho BT - Rev. Inst. Med. Trop. Sao Paulo (2015 Sep-Oct)

- CD25 expression on CD4+ and CD8+ T lymphocytes after incubation with VZV specific antigens. The final value of positive cells was obtained by subtracting the percentage of cells stimulated with cell supernatant of non-VZV-infected cells (negative control) from the percentage of cells from the culture in presence of the stimulus (VZV antigen). Adapted from VIANA et al., 201018.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4660460&req=5

f01: - CD25 expression on CD4+ and CD8+ T lymphocytes after incubation with VZV specific antigens. The final value of positive cells was obtained by subtracting the percentage of cells stimulated with cell supernatant of non-VZV-infected cells (negative control) from the percentage of cells from the culture in presence of the stimulus (VZV antigen). Adapted from VIANA et al., 201018.
Mentions: At the time of varicella infection, the patient's CD4+ and CD8+ T lymphocyte counts were 2388 cells/mm3 and 1293 cells/mm3, respectively. Fifteen days after infection, both CD4+ and CD8+ T cells expressed CD25 upon in vitro stimulation with VZV specific antigens18 (Fig. 1).

Bottom Line: We describe the case of an eight-year-old boy with X-linked agammaglobulinemia who developed mild varicella despite regular intravenous immunoglobulin (IVIG) therapy.He maintained protective antibody levels against varicella and the previous batches of IVIG that he received had adequate varicella-specific IgG levels.The case illustrates that IVIG may not prevent VZV infection.

View Article: PubMed Central - PubMed

Affiliation: Departmento de Pediatria, Universidade Federal de São Paulo, São Paulo, SP, Brasil, aimeenobre@yahoo.com.br; belinhagonzalez@hotmail.com; m.isabelmp@uol.com.br; beacarvalho@terra.com.br.

ABSTRACT
We describe the case of an eight-year-old boy with X-linked agammaglobulinemia who developed mild varicella despite regular intravenous immunoglobulin (IVIG) therapy. He maintained protective antibody levels against varicella and the previous batches of IVIG that he received had adequate varicella-specific IgG levels. The case illustrates that IVIG may not prevent VZV infection.

Show MeSH
Related in: MedlinePlus