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Clinicopathologic significance of legumain overexpression in cancer: a systematic review and meta-analysis.

Zhen Y, Chunlei G, Wenzhi S, Shuangtao Z, Na L, Rongrong W, Xiaohe L, Haiying N, Dehong L, Shan J, Xiaoyue T, Rong X - Sci Rep (2015)

Bottom Line: Since reports on the clinical significance of legumain in cancer have shown inconsistent results, we systematically evaluated clinical indicators of legumain in cancer.Meta-analysis showed that legumain was overexpressed in cancer compared with in normal tissue and was higher in stage III-IV disease than in I-II disease.Moreover, legumain overexpression was correlated with poor prognosis and clinical stage.

View Article: PubMed Central - PubMed

Affiliation: Department of Tumor Molecular Biology, Nankai University School of Medicine, Tianjin 371000, China.

ABSTRACT
Since reports on the clinical significance of legumain in cancer have shown inconsistent results, we systematically evaluated clinical indicators of legumain in cancer. We searched the Cochrane Library, PubMed, Embase, and EBSCO databases and the Wangfang and CNKI databases in China by using "legumain" and ("neoplasms" OR "cancer") as search terms. We included case-controlled studies of legumain and cancer. The quality of the studies was evaluated by using Lichtenstein's guidelines, and valid data was extracted for analysis. In total, 10 articles were included in this study. Meta-analysis showed that legumain was overexpressed in cancer compared with in normal tissue and was higher in stage III-IV disease than in I-II disease. Moreover, legumain overexpression was correlated with poor prognosis and clinical stage. Furthermore, Cancer Genome Atlas data showed that among patients with rectal cancer, those with tumors overexpressing legumain had shorter overall survival than those in the low expression group (P < 0.05). Legumain appears to be involved in tumor development and deterioration; thus, it can potentially be developed into both a marker for monitoring and diagnosing tumors and a therapeutic target.

No MeSH data available.


Related in: MedlinePlus

Funnel plot of risk ratios of legumain overexpression in cancer tissue vs normal tissue groups.
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f6: Funnel plot of risk ratios of legumain overexpression in cancer tissue vs normal tissue groups.

Mentions: In funnel plots of cancer tissue vs normal tissue (Fig. 6), Egger’s test showed P < 0.05 and Begg’s test showed P > 0.05. We considered Begg’s test to be more appropriate because the data was heterogeneous. The plots for well vs moderate–poor differentiation (Fig. 7) and male vs female showed an even and symmetrical distribution (Egger’s and Begg’s tests: P > 0.05 for both), indicating no publication bias.


Clinicopathologic significance of legumain overexpression in cancer: a systematic review and meta-analysis.

Zhen Y, Chunlei G, Wenzhi S, Shuangtao Z, Na L, Rongrong W, Xiaohe L, Haiying N, Dehong L, Shan J, Xiaoyue T, Rong X - Sci Rep (2015)

Funnel plot of risk ratios of legumain overexpression in cancer tissue vs normal tissue groups.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4660395&req=5

f6: Funnel plot of risk ratios of legumain overexpression in cancer tissue vs normal tissue groups.
Mentions: In funnel plots of cancer tissue vs normal tissue (Fig. 6), Egger’s test showed P < 0.05 and Begg’s test showed P > 0.05. We considered Begg’s test to be more appropriate because the data was heterogeneous. The plots for well vs moderate–poor differentiation (Fig. 7) and male vs female showed an even and symmetrical distribution (Egger’s and Begg’s tests: P > 0.05 for both), indicating no publication bias.

Bottom Line: Since reports on the clinical significance of legumain in cancer have shown inconsistent results, we systematically evaluated clinical indicators of legumain in cancer.Meta-analysis showed that legumain was overexpressed in cancer compared with in normal tissue and was higher in stage III-IV disease than in I-II disease.Moreover, legumain overexpression was correlated with poor prognosis and clinical stage.

View Article: PubMed Central - PubMed

Affiliation: Department of Tumor Molecular Biology, Nankai University School of Medicine, Tianjin 371000, China.

ABSTRACT
Since reports on the clinical significance of legumain in cancer have shown inconsistent results, we systematically evaluated clinical indicators of legumain in cancer. We searched the Cochrane Library, PubMed, Embase, and EBSCO databases and the Wangfang and CNKI databases in China by using "legumain" and ("neoplasms" OR "cancer") as search terms. We included case-controlled studies of legumain and cancer. The quality of the studies was evaluated by using Lichtenstein's guidelines, and valid data was extracted for analysis. In total, 10 articles were included in this study. Meta-analysis showed that legumain was overexpressed in cancer compared with in normal tissue and was higher in stage III-IV disease than in I-II disease. Moreover, legumain overexpression was correlated with poor prognosis and clinical stage. Furthermore, Cancer Genome Atlas data showed that among patients with rectal cancer, those with tumors overexpressing legumain had shorter overall survival than those in the low expression group (P < 0.05). Legumain appears to be involved in tumor development and deterioration; thus, it can potentially be developed into both a marker for monitoring and diagnosing tumors and a therapeutic target.

No MeSH data available.


Related in: MedlinePlus