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Periventricular white matter abnormalities and restricted repetitive behavior in autism spectrum disorder.

Blackmon K, Ben-Avi E, Wang X, Pardoe HR, Di Martino A, Halgren E, Devinsky O, Thesen T, Kuzniecky R - Neuroimage Clin (2015)

Bottom Line: Here, we utilize a quantitative approach to determine whether a volumetric measure of heterotopic gray matter in the white matter is elevated in people with ASD, relative to typically developing controls (TDC).Visual review resulted in equivalent proportions of imaging abnormalities in the ASD and TDC group.This finding was replicated in the independent, multi-site sample.

View Article: PubMed Central - PubMed

Affiliation: NYU Comprehensive Epilepsy Center, Department of Neurology, New York University School of Medicine, New York, NY 10016, USA.

ABSTRACT
Malformations of cortical development are found at higher rates in autism spectrum disorder (ASD) than in healthy controls on postmortem neuropathological evaluation but are more variably observed on visual review of in-vivo MRI brain scans. This may be due to the visually elusive nature of many malformations on MRI. Here, we utilize a quantitative approach to determine whether a volumetric measure of heterotopic gray matter in the white matter is elevated in people with ASD, relative to typically developing controls (TDC). Data from a primary sample of 48 children/young adults with ASD and 48 age-, and gender-matched TDCs, selected from the Autism Brain Imaging Data Exchange (ABIDE) open-access database, were analyzed to compare groups on (1) blinded review of high-resolution T1-weighted research sequences; and (2) quantitative measurement of white matter hypointensity (WMH) volume calculated from the same T1-weighted scans. Groupwise WMH volume comparisons were repeated in an independent, multi-site sample (80 ASD/80 TDC), also selected from ABIDE. Visual review resulted in equivalent proportions of imaging abnormalities in the ASD and TDC group. However, quantitative analysis revealed elevated periventricular and deep subcortical WMH volumes in ASD. This finding was replicated in the independent, multi-site sample. Periventricular WMH volume was not associated with age but was associated with greater restricted repetitive behaviors on both parent-reported and clinician-rated assessment inventories. Thus, findings demonstrate that periventricular WMH volume is elevated in ASD and associated with a higher degree of repetitive behaviors and restricted interests. Although the etiology of focal WMH clusters is unknown, the absence of age effects suggests that they may reflect a static anomaly.

No MeSH data available.


Related in: MedlinePlus

Scatterplots depicting linear relationship between WMH-corrected volumes (i.e., periventricular and deep subcortical WMH volume) and A.) Autism Diagnostic Observation Schedule Stereotyped Behaviors and Repetitive Interests; and B.) Autism Diagnostic Inventory—Revised Restrictive, Repetitive Behaviors.
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f0020: Scatterplots depicting linear relationship between WMH-corrected volumes (i.e., periventricular and deep subcortical WMH volume) and A.) Autism Diagnostic Observation Schedule Stereotyped Behaviors and Repetitive Interests; and B.) Autism Diagnostic Inventory—Revised Restrictive, Repetitive Behaviors.

Mentions: There was no correlation between WMH-corrected volume and ADOS-G total algorithm scores (r = 0.12; p = 0.46). Within the specific ADOS-G subscales, WMH-corrected volume was positively correlated with the SBRI subscale (r = 0.36; p = 0.02) (Fig. 4A) but not the SI (r = 0.02; p = 0.89) or Comm (r = 0.28; p = 0.07) subscales. A similar pattern was observed with the ADOS revised algorithm scores (Gotham et al., 2007); there was a positive correlation between WMH-corrected volume and Gotham-RRB scores (r = 0.42; p = 0.01), but not the Gotham-SA (r = 0.05; p = 0.77) or Gotham-Sev (r = 0.14; p = 0.44) scores. Within the ADI-R indices, WMH-corrected volume was positively correlated with the RRB index (r = 0.31; p = 0.05) (Fig. 4B). Correlations between WMH-corrected and the social (r = 0.29; p = 0.07) and verbal (r = 0.3; p = 0.06) indices were similar in effect size but were not significant. Taken together, these results suggest a consistent relationship between periventricular/deep subcortical WMH volume and restricted repetitive behaviors across different measurement modalities (clinician-rated and parent-reported).


Periventricular white matter abnormalities and restricted repetitive behavior in autism spectrum disorder.

Blackmon K, Ben-Avi E, Wang X, Pardoe HR, Di Martino A, Halgren E, Devinsky O, Thesen T, Kuzniecky R - Neuroimage Clin (2015)

Scatterplots depicting linear relationship between WMH-corrected volumes (i.e., periventricular and deep subcortical WMH volume) and A.) Autism Diagnostic Observation Schedule Stereotyped Behaviors and Repetitive Interests; and B.) Autism Diagnostic Inventory—Revised Restrictive, Repetitive Behaviors.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4660377&req=5

f0020: Scatterplots depicting linear relationship between WMH-corrected volumes (i.e., periventricular and deep subcortical WMH volume) and A.) Autism Diagnostic Observation Schedule Stereotyped Behaviors and Repetitive Interests; and B.) Autism Diagnostic Inventory—Revised Restrictive, Repetitive Behaviors.
Mentions: There was no correlation between WMH-corrected volume and ADOS-G total algorithm scores (r = 0.12; p = 0.46). Within the specific ADOS-G subscales, WMH-corrected volume was positively correlated with the SBRI subscale (r = 0.36; p = 0.02) (Fig. 4A) but not the SI (r = 0.02; p = 0.89) or Comm (r = 0.28; p = 0.07) subscales. A similar pattern was observed with the ADOS revised algorithm scores (Gotham et al., 2007); there was a positive correlation between WMH-corrected volume and Gotham-RRB scores (r = 0.42; p = 0.01), but not the Gotham-SA (r = 0.05; p = 0.77) or Gotham-Sev (r = 0.14; p = 0.44) scores. Within the ADI-R indices, WMH-corrected volume was positively correlated with the RRB index (r = 0.31; p = 0.05) (Fig. 4B). Correlations between WMH-corrected and the social (r = 0.29; p = 0.07) and verbal (r = 0.3; p = 0.06) indices were similar in effect size but were not significant. Taken together, these results suggest a consistent relationship between periventricular/deep subcortical WMH volume and restricted repetitive behaviors across different measurement modalities (clinician-rated and parent-reported).

Bottom Line: Here, we utilize a quantitative approach to determine whether a volumetric measure of heterotopic gray matter in the white matter is elevated in people with ASD, relative to typically developing controls (TDC).Visual review resulted in equivalent proportions of imaging abnormalities in the ASD and TDC group.This finding was replicated in the independent, multi-site sample.

View Article: PubMed Central - PubMed

Affiliation: NYU Comprehensive Epilepsy Center, Department of Neurology, New York University School of Medicine, New York, NY 10016, USA.

ABSTRACT
Malformations of cortical development are found at higher rates in autism spectrum disorder (ASD) than in healthy controls on postmortem neuropathological evaluation but are more variably observed on visual review of in-vivo MRI brain scans. This may be due to the visually elusive nature of many malformations on MRI. Here, we utilize a quantitative approach to determine whether a volumetric measure of heterotopic gray matter in the white matter is elevated in people with ASD, relative to typically developing controls (TDC). Data from a primary sample of 48 children/young adults with ASD and 48 age-, and gender-matched TDCs, selected from the Autism Brain Imaging Data Exchange (ABIDE) open-access database, were analyzed to compare groups on (1) blinded review of high-resolution T1-weighted research sequences; and (2) quantitative measurement of white matter hypointensity (WMH) volume calculated from the same T1-weighted scans. Groupwise WMH volume comparisons were repeated in an independent, multi-site sample (80 ASD/80 TDC), also selected from ABIDE. Visual review resulted in equivalent proportions of imaging abnormalities in the ASD and TDC group. However, quantitative analysis revealed elevated periventricular and deep subcortical WMH volumes in ASD. This finding was replicated in the independent, multi-site sample. Periventricular WMH volume was not associated with age but was associated with greater restricted repetitive behaviors on both parent-reported and clinician-rated assessment inventories. Thus, findings demonstrate that periventricular WMH volume is elevated in ASD and associated with a higher degree of repetitive behaviors and restricted interests. Although the etiology of focal WMH clusters is unknown, the absence of age effects suggests that they may reflect a static anomaly.

No MeSH data available.


Related in: MedlinePlus