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Periventricular white matter abnormalities and restricted repetitive behavior in autism spectrum disorder.

Blackmon K, Ben-Avi E, Wang X, Pardoe HR, Di Martino A, Halgren E, Devinsky O, Thesen T, Kuzniecky R - Neuroimage Clin (2015)

Bottom Line: Here, we utilize a quantitative approach to determine whether a volumetric measure of heterotopic gray matter in the white matter is elevated in people with ASD, relative to typically developing controls (TDC).Visual review resulted in equivalent proportions of imaging abnormalities in the ASD and TDC group.This finding was replicated in the independent, multi-site sample.

View Article: PubMed Central - PubMed

Affiliation: NYU Comprehensive Epilepsy Center, Department of Neurology, New York University School of Medicine, New York, NY 10016, USA.

ABSTRACT
Malformations of cortical development are found at higher rates in autism spectrum disorder (ASD) than in healthy controls on postmortem neuropathological evaluation but are more variably observed on visual review of in-vivo MRI brain scans. This may be due to the visually elusive nature of many malformations on MRI. Here, we utilize a quantitative approach to determine whether a volumetric measure of heterotopic gray matter in the white matter is elevated in people with ASD, relative to typically developing controls (TDC). Data from a primary sample of 48 children/young adults with ASD and 48 age-, and gender-matched TDCs, selected from the Autism Brain Imaging Data Exchange (ABIDE) open-access database, were analyzed to compare groups on (1) blinded review of high-resolution T1-weighted research sequences; and (2) quantitative measurement of white matter hypointensity (WMH) volume calculated from the same T1-weighted scans. Groupwise WMH volume comparisons were repeated in an independent, multi-site sample (80 ASD/80 TDC), also selected from ABIDE. Visual review resulted in equivalent proportions of imaging abnormalities in the ASD and TDC group. However, quantitative analysis revealed elevated periventricular and deep subcortical WMH volumes in ASD. This finding was replicated in the independent, multi-site sample. Periventricular WMH volume was not associated with age but was associated with greater restricted repetitive behaviors on both parent-reported and clinician-rated assessment inventories. Thus, findings demonstrate that periventricular WMH volume is elevated in ASD and associated with a higher degree of repetitive behaviors and restricted interests. Although the etiology of focal WMH clusters is unknown, the absence of age effects suggests that they may reflect a static anomaly.

No MeSH data available.


Related in: MedlinePlus

White matter hypointensity volumes (WMHV) are elevated in ASD. Bar graph depicting group differences in total average WMHV and WMHV-corrected (WMHV-corr) volumes. WMHV-corr volumes include only the periventricular and deep subcortical white matter clusters. Blue bars depict the autism spectrum disorder (ASD) group and red bars depict the typically developing control (TDC) group. Sample 1 refers to the primary single-scanner NYU sample (48 ASD/48 TDC). Sample 2 refers to the secondary multi-site sample (80 ASD/80 TDC). Error bars depict standard error.
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f0015: White matter hypointensity volumes (WMHV) are elevated in ASD. Bar graph depicting group differences in total average WMHV and WMHV-corrected (WMHV-corr) volumes. WMHV-corr volumes include only the periventricular and deep subcortical white matter clusters. Blue bars depict the autism spectrum disorder (ASD) group and red bars depict the typically developing control (TDC) group. Sample 1 refers to the primary single-scanner NYU sample (48 ASD/48 TDC). Sample 2 refers to the secondary multi-site sample (80 ASD/80 TDC). Error bars depict standard error.

Mentions: Similar to the primary single-site sample, there were several positive WMH volume outliers in the multi-site sample resulting in a non-normal distribution; therefore, logarithmic transformation was applied to the total WMH volume measure. Total WMH volume was elevated in the ASD group relative to the TDC group [F = 12.92; p = 0.0004; ASD: mean = 2367.7 mm3 (SD = 1271.74 mm3); TDC: mean = 1883.74 mm3 (SD = 742.13 mm3)] (Fig. 3). There was also a main effect of site on total WMH volume (F = 4.77; p = 0.00008) but no interaction between group and site (F = 1.13; p = 0.0035).


Periventricular white matter abnormalities and restricted repetitive behavior in autism spectrum disorder.

Blackmon K, Ben-Avi E, Wang X, Pardoe HR, Di Martino A, Halgren E, Devinsky O, Thesen T, Kuzniecky R - Neuroimage Clin (2015)

White matter hypointensity volumes (WMHV) are elevated in ASD. Bar graph depicting group differences in total average WMHV and WMHV-corrected (WMHV-corr) volumes. WMHV-corr volumes include only the periventricular and deep subcortical white matter clusters. Blue bars depict the autism spectrum disorder (ASD) group and red bars depict the typically developing control (TDC) group. Sample 1 refers to the primary single-scanner NYU sample (48 ASD/48 TDC). Sample 2 refers to the secondary multi-site sample (80 ASD/80 TDC). Error bars depict standard error.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4660377&req=5

f0015: White matter hypointensity volumes (WMHV) are elevated in ASD. Bar graph depicting group differences in total average WMHV and WMHV-corrected (WMHV-corr) volumes. WMHV-corr volumes include only the periventricular and deep subcortical white matter clusters. Blue bars depict the autism spectrum disorder (ASD) group and red bars depict the typically developing control (TDC) group. Sample 1 refers to the primary single-scanner NYU sample (48 ASD/48 TDC). Sample 2 refers to the secondary multi-site sample (80 ASD/80 TDC). Error bars depict standard error.
Mentions: Similar to the primary single-site sample, there were several positive WMH volume outliers in the multi-site sample resulting in a non-normal distribution; therefore, logarithmic transformation was applied to the total WMH volume measure. Total WMH volume was elevated in the ASD group relative to the TDC group [F = 12.92; p = 0.0004; ASD: mean = 2367.7 mm3 (SD = 1271.74 mm3); TDC: mean = 1883.74 mm3 (SD = 742.13 mm3)] (Fig. 3). There was also a main effect of site on total WMH volume (F = 4.77; p = 0.00008) but no interaction between group and site (F = 1.13; p = 0.0035).

Bottom Line: Here, we utilize a quantitative approach to determine whether a volumetric measure of heterotopic gray matter in the white matter is elevated in people with ASD, relative to typically developing controls (TDC).Visual review resulted in equivalent proportions of imaging abnormalities in the ASD and TDC group.This finding was replicated in the independent, multi-site sample.

View Article: PubMed Central - PubMed

Affiliation: NYU Comprehensive Epilepsy Center, Department of Neurology, New York University School of Medicine, New York, NY 10016, USA.

ABSTRACT
Malformations of cortical development are found at higher rates in autism spectrum disorder (ASD) than in healthy controls on postmortem neuropathological evaluation but are more variably observed on visual review of in-vivo MRI brain scans. This may be due to the visually elusive nature of many malformations on MRI. Here, we utilize a quantitative approach to determine whether a volumetric measure of heterotopic gray matter in the white matter is elevated in people with ASD, relative to typically developing controls (TDC). Data from a primary sample of 48 children/young adults with ASD and 48 age-, and gender-matched TDCs, selected from the Autism Brain Imaging Data Exchange (ABIDE) open-access database, were analyzed to compare groups on (1) blinded review of high-resolution T1-weighted research sequences; and (2) quantitative measurement of white matter hypointensity (WMH) volume calculated from the same T1-weighted scans. Groupwise WMH volume comparisons were repeated in an independent, multi-site sample (80 ASD/80 TDC), also selected from ABIDE. Visual review resulted in equivalent proportions of imaging abnormalities in the ASD and TDC group. However, quantitative analysis revealed elevated periventricular and deep subcortical WMH volumes in ASD. This finding was replicated in the independent, multi-site sample. Periventricular WMH volume was not associated with age but was associated with greater restricted repetitive behaviors on both parent-reported and clinician-rated assessment inventories. Thus, findings demonstrate that periventricular WMH volume is elevated in ASD and associated with a higher degree of repetitive behaviors and restricted interests. Although the etiology of focal WMH clusters is unknown, the absence of age effects suggests that they may reflect a static anomaly.

No MeSH data available.


Related in: MedlinePlus