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Resting-state cerebellar-cerebral networks are differently affected in first-episode, drug-naive schizophrenia patients and unaffected siblings.

Guo W, Liu F, Chen J, Wu R, Zhang Z, Yu M, Xiao C, Zhao J - Sci Rep (2015)

Bottom Line: The patients have decreased right dorsal attention network (DAN) seed - bilateral cerebellum 4,5 connectivity relative to the controls.By contrast, the siblings exhibit increased FC between the right DAN seed and the right cerebellum 6 and right cerebellum 4,5 compared to the controls.There are no correlations between abnormal cerebellar-cerebral connectivities and clinical variables.

View Article: PubMed Central - PubMed

Affiliation: Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan 410011, China.

ABSTRACT
Dysconnectivity hypothesis posits that schizophrenia is a disorder with dysconnectivity of the cortico-cerebellar-thalamic-cortical circuit (CCTCC). However, it remains unclear to the changes of the cerebral connectivity with the cerebellum in schizophrenia patients and unaffected siblings. Forty-nine patients with first-episode, drug-naive schizophrenia patients, 46 unaffected siblings of schizophrenia patients and 46 healthy controls participated in the study. Seed-based resting-state functional connectivity approach was employed to analyze the data. Compared with the controls, the patients and the siblings share increased default-mode network (DMN) seed - right Crus II connectivity. The patients have decreased right dorsal attention network (DAN) seed - bilateral cerebellum 4,5 connectivity relative to the controls. By contrast, the siblings exhibit increased FC between the right DAN seed and the right cerebellum 6 and right cerebellum 4,5 compared to the controls. No other abnormal connectivities (executive control network and salience network) are observed in the patients/siblings relative to the controls. There are no correlations between abnormal cerebellar-cerebral connectivities and clinical variables. Cerebellar-cerebral connectivity of brain networks within the cerebellum are differently affected in first-episode, drug-naive schizophrenia patients and unaffected siblings. Increased DMN connectivity with the cerebellum may serve as potential endophenotype for schizophrenia.

No MeSH data available.


Related in: MedlinePlus

Increased default-mode network seed – right Crus II connectivity shared by the patients and the siblings.Red denotes increased connectivity in the patients/siblings relative to the controls and the color bar indicates T values from post hoc t-tests.
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f1: Increased default-mode network seed – right Crus II connectivity shared by the patients and the siblings.Red denotes increased connectivity in the patients/siblings relative to the controls and the color bar indicates T values from post hoc t-tests.

Mentions: Compared with the controls, the patients and the siblings share increased DMN seed – right Crus II connectivity by using post hoc t-tests (Fig. 1 and Table 2). The patients have decreased right DAN seed – bilateral cerebellum 4,5 connectivity relative to the controls (Fig. 2 and Table 2). By contrast, the siblings exhibit increased FC between the right DAN seed and the right cerebellum 6 and right cerebellum 4,5 compared to the controls (Fig. 3 and Table 2). No other abnormal connectivities (ECN and SN) are observed in the patients/siblings relative to the controls.


Resting-state cerebellar-cerebral networks are differently affected in first-episode, drug-naive schizophrenia patients and unaffected siblings.

Guo W, Liu F, Chen J, Wu R, Zhang Z, Yu M, Xiao C, Zhao J - Sci Rep (2015)

Increased default-mode network seed – right Crus II connectivity shared by the patients and the siblings.Red denotes increased connectivity in the patients/siblings relative to the controls and the color bar indicates T values from post hoc t-tests.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4660304&req=5

f1: Increased default-mode network seed – right Crus II connectivity shared by the patients and the siblings.Red denotes increased connectivity in the patients/siblings relative to the controls and the color bar indicates T values from post hoc t-tests.
Mentions: Compared with the controls, the patients and the siblings share increased DMN seed – right Crus II connectivity by using post hoc t-tests (Fig. 1 and Table 2). The patients have decreased right DAN seed – bilateral cerebellum 4,5 connectivity relative to the controls (Fig. 2 and Table 2). By contrast, the siblings exhibit increased FC between the right DAN seed and the right cerebellum 6 and right cerebellum 4,5 compared to the controls (Fig. 3 and Table 2). No other abnormal connectivities (ECN and SN) are observed in the patients/siblings relative to the controls.

Bottom Line: The patients have decreased right dorsal attention network (DAN) seed - bilateral cerebellum 4,5 connectivity relative to the controls.By contrast, the siblings exhibit increased FC between the right DAN seed and the right cerebellum 6 and right cerebellum 4,5 compared to the controls.There are no correlations between abnormal cerebellar-cerebral connectivities and clinical variables.

View Article: PubMed Central - PubMed

Affiliation: Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan 410011, China.

ABSTRACT
Dysconnectivity hypothesis posits that schizophrenia is a disorder with dysconnectivity of the cortico-cerebellar-thalamic-cortical circuit (CCTCC). However, it remains unclear to the changes of the cerebral connectivity with the cerebellum in schizophrenia patients and unaffected siblings. Forty-nine patients with first-episode, drug-naive schizophrenia patients, 46 unaffected siblings of schizophrenia patients and 46 healthy controls participated in the study. Seed-based resting-state functional connectivity approach was employed to analyze the data. Compared with the controls, the patients and the siblings share increased default-mode network (DMN) seed - right Crus II connectivity. The patients have decreased right dorsal attention network (DAN) seed - bilateral cerebellum 4,5 connectivity relative to the controls. By contrast, the siblings exhibit increased FC between the right DAN seed and the right cerebellum 6 and right cerebellum 4,5 compared to the controls. No other abnormal connectivities (executive control network and salience network) are observed in the patients/siblings relative to the controls. There are no correlations between abnormal cerebellar-cerebral connectivities and clinical variables. Cerebellar-cerebral connectivity of brain networks within the cerebellum are differently affected in first-episode, drug-naive schizophrenia patients and unaffected siblings. Increased DMN connectivity with the cerebellum may serve as potential endophenotype for schizophrenia.

No MeSH data available.


Related in: MedlinePlus