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White matter and reading deficits after pediatric traumatic brain injury: A diffusion tensor imaging study.

Johnson CP, Juranek J, Swank PR, Kramer L, Cox CS, Ewing-Cobbs L - Neuroimage Clin (2015)

Bottom Line: Reading fluency and comprehension were hypothesized to relate to the superior longitudinal fasciculus, inferior fronto-occipital fasciculus, and cingulum bundle.Results support the association of a dorsal pathway via the superior longitudinal fasciculus with both sight word reading and phonemic decoding.Reading fluency was associated with the integrity of the cingulum bundle.

View Article: PubMed Central - PubMed

Affiliation: University of Hawaii at Hilo, Department of Psychology, 200 W Kawili St., Hilo, HI 96720, United States.

ABSTRACT
Pediatric traumatic brain injury often results in significant long-term deficits in mastery of reading ability. This study aimed to identify white matter pathways that, when damaged, predicted reading deficits in children. Based on the dual-route model of word reading, we predicted that integrity of the inferior fronto-occipital fasciculus would be related to performance in sight word identification while integrity of the superior longitudinal fasciculus would be related to performance in phonemic decoding. Reading fluency and comprehension were hypothesized to relate to the superior longitudinal fasciculus, inferior fronto-occipital fasciculus, and cingulum bundle. The connectivity of white matter pathways was used to predict reading deficits in children aged 6 to 16 years with traumatic brain injury (n = 29) and those with orthopedic injury (n = 27) using tract-based spatial statistics. Results showed that children with traumatic brain injury and reduced microstructural integrity of the superior longitudinal fasciculus demonstrated reduced word-reading ability on sight word and phonemic decoding tasks. Additionally, children with traumatic brain injury and microstructural changes involving the cingulum bundle demonstrated reduced reading fluency. Results support the association of a dorsal pathway via the superior longitudinal fasciculus with both sight word reading and phonemic decoding. No association was identified between the inferior fronto-occipital fasciculus and sight word reading or phonemic decoding. Reading fluency was associated with the integrity of the cingulum bundle. These findings support dissociable pathways predicting word reading and fluency using Diffusion Tensor Imaging and provide additional information for developing models of acquired reading deficits by specifying areas of brain damage which may predict reading deficits following recovery from the acute phase of TBI.

No MeSH data available.


Related in: MedlinePlus

Interaction Effect of Group and Cingulum Bundle Integrity on GORT-4 and WJ-III Reading Fluency tasks.
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f0015: Interaction Effect of Group and Cingulum Bundle Integrity on GORT-4 and WJ-III Reading Fluency tasks.

Mentions: Prediction of fluency and comprehension. Neither the inferior fronto-occipital nor superior longitudinal fasciculi predicted fluency for reading sentences or connected text. There was an interaction effect between group and FA of the cingulum bundle in predicting both silent and oral reading fluency performance. This interaction indicates that lower FA of the cingulum bundle in the TBI group predicted lower reading fluency. The results of the general linear models for fluency and comprehension are presented in Table 6 and the interaction effects are illustrated in Fig. 3. No pathways predicted comprehension performance in either group.


White matter and reading deficits after pediatric traumatic brain injury: A diffusion tensor imaging study.

Johnson CP, Juranek J, Swank PR, Kramer L, Cox CS, Ewing-Cobbs L - Neuroimage Clin (2015)

Interaction Effect of Group and Cingulum Bundle Integrity on GORT-4 and WJ-III Reading Fluency tasks.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4660156&req=5

f0015: Interaction Effect of Group and Cingulum Bundle Integrity on GORT-4 and WJ-III Reading Fluency tasks.
Mentions: Prediction of fluency and comprehension. Neither the inferior fronto-occipital nor superior longitudinal fasciculi predicted fluency for reading sentences or connected text. There was an interaction effect between group and FA of the cingulum bundle in predicting both silent and oral reading fluency performance. This interaction indicates that lower FA of the cingulum bundle in the TBI group predicted lower reading fluency. The results of the general linear models for fluency and comprehension are presented in Table 6 and the interaction effects are illustrated in Fig. 3. No pathways predicted comprehension performance in either group.

Bottom Line: Reading fluency and comprehension were hypothesized to relate to the superior longitudinal fasciculus, inferior fronto-occipital fasciculus, and cingulum bundle.Results support the association of a dorsal pathway via the superior longitudinal fasciculus with both sight word reading and phonemic decoding.Reading fluency was associated with the integrity of the cingulum bundle.

View Article: PubMed Central - PubMed

Affiliation: University of Hawaii at Hilo, Department of Psychology, 200 W Kawili St., Hilo, HI 96720, United States.

ABSTRACT
Pediatric traumatic brain injury often results in significant long-term deficits in mastery of reading ability. This study aimed to identify white matter pathways that, when damaged, predicted reading deficits in children. Based on the dual-route model of word reading, we predicted that integrity of the inferior fronto-occipital fasciculus would be related to performance in sight word identification while integrity of the superior longitudinal fasciculus would be related to performance in phonemic decoding. Reading fluency and comprehension were hypothesized to relate to the superior longitudinal fasciculus, inferior fronto-occipital fasciculus, and cingulum bundle. The connectivity of white matter pathways was used to predict reading deficits in children aged 6 to 16 years with traumatic brain injury (n = 29) and those with orthopedic injury (n = 27) using tract-based spatial statistics. Results showed that children with traumatic brain injury and reduced microstructural integrity of the superior longitudinal fasciculus demonstrated reduced word-reading ability on sight word and phonemic decoding tasks. Additionally, children with traumatic brain injury and microstructural changes involving the cingulum bundle demonstrated reduced reading fluency. Results support the association of a dorsal pathway via the superior longitudinal fasciculus with both sight word reading and phonemic decoding. No association was identified between the inferior fronto-occipital fasciculus and sight word reading or phonemic decoding. Reading fluency was associated with the integrity of the cingulum bundle. These findings support dissociable pathways predicting word reading and fluency using Diffusion Tensor Imaging and provide additional information for developing models of acquired reading deficits by specifying areas of brain damage which may predict reading deficits following recovery from the acute phase of TBI.

No MeSH data available.


Related in: MedlinePlus