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Characterization and Compatibility Studies of Different Rate Retardant Polymer Loaded Microspheres by Solvent Evaporation Technique: In Vitro-In Vivo Study of Vildagliptin as a Model Drug.

Dewan I, Islam S, Rana MS - J Drug Deliv (2015)

Bottom Line: The SEM, DSC, and FTIR studies have been done to confirm good spheres and smooth surface as well as interaction along with drug and polymer.In this experiment, it is difficult to explain the exact mechanism of drug release.At last it can be concluded that all in vitro and in vivo experiments exhibited promising result to treat type II diabetes mellitus with Vildagliptin microspheres.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacy, Jahangirnagar University, Savar 1342, Dhaka, Bangladesh ; Department of Pharmacy, University of Asia Pacific, Dhanmondi, Dhaka 1209, Bangladesh.

ABSTRACT
The present study has been performed to microencapsulate the antidiabetic drug of Vildagliptin to get sustained release of drug. The attempt of this study was to formulate and evaluate the Vildagliptin loaded microspheres by emulsion solvent evaporation technique using different polymers like Eudragit RL100, Eudragit RS100, Ethyl cellulose, and Methocel K100M. In vitro dissolution studies were carried out in 0.1 N HCl for 8 hours according to USP paddle method. The maximum and minimum drug release were observed as 92.5% and 68.5% from microspheres, respectively, after 8 hours. Release kinetics were studied in different mathematical release models to find out the linear relationship and release rate of drug. The SEM, DSC, and FTIR studies have been done to confirm good spheres and smooth surface as well as interaction along with drug and polymer. In this experiment, it is difficult to explain the exact mechanism of drug release. But the drug might be released by both diffusion and erosion as the correlation coefficient (R (2)) best fitted with Korsmeyer model and release exponent (n) was 0.45-0.89. At last it can be concluded that all in vitro and in vivo experiments exhibited promising result to treat type II diabetes mellitus with Vildagliptin microspheres.

No MeSH data available.


Related in: MedlinePlus

Comparative release studies of Vildagliptin microspheres after 8 hrs.
© Copyright Policy - open-access
Related In: Results  -  Collection


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fig5: Comparative release studies of Vildagliptin microspheres after 8 hrs.

Mentions: From Figure 5 it has been seen that drug entrapment efficiency of different formulations was in range of 82.56% to 94.59%. It has been seen that when percent of drug loading increased the percent of drug entrapment also increased for all formulations containing Eudragit RS100 and Ethyl cellulose (94.59%, 90.89%, and 88.43%). This tendency was found for other formulations containing Eudragit RL100 and Ethyl cellulose; Eudragit RS100 and Methocel K100M; Eudragit RL100 and Methocel K100M.


Characterization and Compatibility Studies of Different Rate Retardant Polymer Loaded Microspheres by Solvent Evaporation Technique: In Vitro-In Vivo Study of Vildagliptin as a Model Drug.

Dewan I, Islam S, Rana MS - J Drug Deliv (2015)

Comparative release studies of Vildagliptin microspheres after 8 hrs.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4660022&req=5

fig5: Comparative release studies of Vildagliptin microspheres after 8 hrs.
Mentions: From Figure 5 it has been seen that drug entrapment efficiency of different formulations was in range of 82.56% to 94.59%. It has been seen that when percent of drug loading increased the percent of drug entrapment also increased for all formulations containing Eudragit RS100 and Ethyl cellulose (94.59%, 90.89%, and 88.43%). This tendency was found for other formulations containing Eudragit RL100 and Ethyl cellulose; Eudragit RS100 and Methocel K100M; Eudragit RL100 and Methocel K100M.

Bottom Line: The SEM, DSC, and FTIR studies have been done to confirm good spheres and smooth surface as well as interaction along with drug and polymer.In this experiment, it is difficult to explain the exact mechanism of drug release.At last it can be concluded that all in vitro and in vivo experiments exhibited promising result to treat type II diabetes mellitus with Vildagliptin microspheres.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacy, Jahangirnagar University, Savar 1342, Dhaka, Bangladesh ; Department of Pharmacy, University of Asia Pacific, Dhanmondi, Dhaka 1209, Bangladesh.

ABSTRACT
The present study has been performed to microencapsulate the antidiabetic drug of Vildagliptin to get sustained release of drug. The attempt of this study was to formulate and evaluate the Vildagliptin loaded microspheres by emulsion solvent evaporation technique using different polymers like Eudragit RL100, Eudragit RS100, Ethyl cellulose, and Methocel K100M. In vitro dissolution studies were carried out in 0.1 N HCl for 8 hours according to USP paddle method. The maximum and minimum drug release were observed as 92.5% and 68.5% from microspheres, respectively, after 8 hours. Release kinetics were studied in different mathematical release models to find out the linear relationship and release rate of drug. The SEM, DSC, and FTIR studies have been done to confirm good spheres and smooth surface as well as interaction along with drug and polymer. In this experiment, it is difficult to explain the exact mechanism of drug release. But the drug might be released by both diffusion and erosion as the correlation coefficient (R (2)) best fitted with Korsmeyer model and release exponent (n) was 0.45-0.89. At last it can be concluded that all in vitro and in vivo experiments exhibited promising result to treat type II diabetes mellitus with Vildagliptin microspheres.

No MeSH data available.


Related in: MedlinePlus