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Association of Cytokeratin and Vimentin Protein in the Genesis of Transitional Cell Carcinoma of Urinary Bladder Patients.

Rahmani AH, Babiker AY, AlWanian WM, Elsiddig SA, Faragalla HE, Aly SM - Dis. Markers (2015)

Bottom Line: Vimentin expression increased with the grade of TCC and this difference was statistically significant whereas expression of CK decreased according to the grade of TCC.Furthermore, it was also observed that expression pattern of vimentin was high in ≥55 years as compared to <55 age group patients and these differences were significant in men as compared to women.Expression pattern of CK did not show any significant relation with age and gender.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Qassim 51452, Saudi Arabia.

ABSTRACT
The aim of study was to examine the localization and distribution of cytokeratin (CK) and vimentin protein and their association with clinical outcome of the TCC patients. Expression pattern of cytokeratin and vimentin was evaluated by immunohistochemistry in TCC cases and inflammatory lesions. Cytoplasmic expression of CK was noticed in 52.17% of TCC cases and its expression was not observed in inflammatory lesions of bladder specimens. Vimentin showed expression in 69.00% cases of TCC. Significant differences were noticed in expression pattern of CK and vimentin in inflammatory lesion and Transitional Cell Carcinoma cases. Vimentin expression increased with the grade of TCC and this difference was statistically significant whereas expression of CK decreased according to the grade of TCC. Furthermore, it was also observed that expression pattern of vimentin was high in ≥55 years as compared to <55 age group patients and these differences were significant in men as compared to women. Expression pattern of CK did not show any significant relation with age and gender. Therefore, it can be concluded that cytokeratin and vimentin will be helpful markers in the early diagnosis of Transitional Cell Carcinoma/bladder carcinoma.

No MeSH data available.


Related in: MedlinePlus

Vimentin showed expression in Transitional Cell Carcinoma (orig. mag ×100).
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fig3: Vimentin showed expression in Transitional Cell Carcinoma (orig. mag ×100).

Mentions: Vimentin expressions were analyzed in TCC cases and it was noticed that vimentin was overexpressed in 32 (69.56%) of TCC cases (Table 1 and Figure 3) and 14 cases (30.43%) did not show any expression of vimentin (Figure 4). One case out of 10 showed expression in inflammatory lesions of bladder. This difference of expression pattern in TCC and inflammatory lesions was statistically significant. Expression of vimentin was further categorized according to grade, gender, and sex. The positivity of vimentin increased according to grade of the TCC and it was (6 cases, 42.85%), (13 cases, 72.22%), and (13 cases, 92.85%) in Grade I, Grade II and Grade III, respectively (Table 1). The expression pattern of vimentin was statistically significant according to grade. The TCC cases were divided into two groups on the basis of age, that is, <55 years and ≥55 years, and it was observed that expression of vimentin was high in ≥55 years as compared to <55 years and these differences were significant in men as compared to women (Table 1).


Association of Cytokeratin and Vimentin Protein in the Genesis of Transitional Cell Carcinoma of Urinary Bladder Patients.

Rahmani AH, Babiker AY, AlWanian WM, Elsiddig SA, Faragalla HE, Aly SM - Dis. Markers (2015)

Vimentin showed expression in Transitional Cell Carcinoma (orig. mag ×100).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4660019&req=5

fig3: Vimentin showed expression in Transitional Cell Carcinoma (orig. mag ×100).
Mentions: Vimentin expressions were analyzed in TCC cases and it was noticed that vimentin was overexpressed in 32 (69.56%) of TCC cases (Table 1 and Figure 3) and 14 cases (30.43%) did not show any expression of vimentin (Figure 4). One case out of 10 showed expression in inflammatory lesions of bladder. This difference of expression pattern in TCC and inflammatory lesions was statistically significant. Expression of vimentin was further categorized according to grade, gender, and sex. The positivity of vimentin increased according to grade of the TCC and it was (6 cases, 42.85%), (13 cases, 72.22%), and (13 cases, 92.85%) in Grade I, Grade II and Grade III, respectively (Table 1). The expression pattern of vimentin was statistically significant according to grade. The TCC cases were divided into two groups on the basis of age, that is, <55 years and ≥55 years, and it was observed that expression of vimentin was high in ≥55 years as compared to <55 years and these differences were significant in men as compared to women (Table 1).

Bottom Line: Vimentin expression increased with the grade of TCC and this difference was statistically significant whereas expression of CK decreased according to the grade of TCC.Furthermore, it was also observed that expression pattern of vimentin was high in ≥55 years as compared to <55 age group patients and these differences were significant in men as compared to women.Expression pattern of CK did not show any significant relation with age and gender.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Qassim 51452, Saudi Arabia.

ABSTRACT
The aim of study was to examine the localization and distribution of cytokeratin (CK) and vimentin protein and their association with clinical outcome of the TCC patients. Expression pattern of cytokeratin and vimentin was evaluated by immunohistochemistry in TCC cases and inflammatory lesions. Cytoplasmic expression of CK was noticed in 52.17% of TCC cases and its expression was not observed in inflammatory lesions of bladder specimens. Vimentin showed expression in 69.00% cases of TCC. Significant differences were noticed in expression pattern of CK and vimentin in inflammatory lesion and Transitional Cell Carcinoma cases. Vimentin expression increased with the grade of TCC and this difference was statistically significant whereas expression of CK decreased according to the grade of TCC. Furthermore, it was also observed that expression pattern of vimentin was high in ≥55 years as compared to <55 age group patients and these differences were significant in men as compared to women. Expression pattern of CK did not show any significant relation with age and gender. Therefore, it can be concluded that cytokeratin and vimentin will be helpful markers in the early diagnosis of Transitional Cell Carcinoma/bladder carcinoma.

No MeSH data available.


Related in: MedlinePlus