Limits...
Comparative study of two doses of intrathecal dexmedetomidine as adjuvant with low dose hyperbaric bupivacaine in ambulatory perianal surgeries: A prospective randomised controlled study.

Sudheesh K, Rao RR, Kavya M, Aarthi J, Rani DD, Nethra SS - Indian J Anaesth (2015)

Bottom Line: Adverse effects if any were noted.No other side effects were observed.Intrathecal DMT 3 μg dose does not produce faster ambulation compared to intrathecal DMT 5 μg though it produces comparable duration of analgesia for perianal surgeries.

View Article: PubMed Central - PubMed

Affiliation: Department of Anaesthesiology, Bangalore Medical College and Research Institute, Bengaluru, Karnataka, India.

ABSTRACT

Background and aims: Dexmedetomidine (DMT), as intrathecal adjuvant has been shown to successfully prolong duration of analgesia but delay the motor recovery. Hence, this study was designed to find out the dose of DMT which can provide satisfactory analgesia without prolonging motor block.

Methods: A total of 50 patients scheduled for elective perianal surgeries were randomly allocated to Groups C or D (n = 25). Group D received hyperbaric bupivacaine 0.5% 4 mg + DMT 5 μg and Group C received hyperbaric bupivacaine 0.5% 4 mg + DMT 3 μg intrathecally. Onset and duration of sensory and motor blockade, duration of analgesia, time for ambulation and first urination were recorded. Adverse effects if any were noted.

Results: Demographic characters, duration of surgery were comparable. The onset of sensory block to S1 was 9.61 ± 5.53 min in Group C compared to 7.69 ± 4.80 min in Group D (P = 0.35). Duration of sensory (145.28 ± 83.17 min - C, 167.85 ± 93.75 min - D, P = 0.5) and motor block (170.53 ± 73.44 min - C, 196.14 ± 84.28 min, P = 0.39) were comparable. Duration of analgesia (337.86 ± 105.11 min - C, 340.78 ± 101.81 min - D, P = 0.9) and time for ambulation (252.46 ± 93.72 min - C, 253.64 ± 88.04 min - D, P = 0.97) were also comparable. One patient in each group had urinary retention requiring catheterization. No other side effects were observed.

Conclusion: Intrathecal DMT 3 μg dose does not produce faster ambulation compared to intrathecal DMT 5 μg though it produces comparable duration of analgesia for perianal surgeries.

No MeSH data available.


Post-operative haemodynamic parameters
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4645353&req=5

Figure 2: Post-operative haemodynamic parameters

Mentions: Intraoperative and post-operative haemodynamic parameters were comparable between the two groups [Figures 1 and 2]. One patient in each group had urinary retention requiring catheterization. No other side effects were observed. The mean sedation score (average of mean sedation score of each patient) was 2.008 ± 0.03 in Group D compared to 2 ± 0.05 in Group C (P = 0.5), and average post-operative sedation scores were two in both groups. None of the patients had sedation scores more than four in either group at any point of time during the study period. None of the patients in either group developed hypotension or bradycardia either in intraoperative period or post-operative period. Post-operative VAS scores were comparable in both groups [Figure 3].


Comparative study of two doses of intrathecal dexmedetomidine as adjuvant with low dose hyperbaric bupivacaine in ambulatory perianal surgeries: A prospective randomised controlled study.

Sudheesh K, Rao RR, Kavya M, Aarthi J, Rani DD, Nethra SS - Indian J Anaesth (2015)

Post-operative haemodynamic parameters
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4645353&req=5

Figure 2: Post-operative haemodynamic parameters
Mentions: Intraoperative and post-operative haemodynamic parameters were comparable between the two groups [Figures 1 and 2]. One patient in each group had urinary retention requiring catheterization. No other side effects were observed. The mean sedation score (average of mean sedation score of each patient) was 2.008 ± 0.03 in Group D compared to 2 ± 0.05 in Group C (P = 0.5), and average post-operative sedation scores were two in both groups. None of the patients had sedation scores more than four in either group at any point of time during the study period. None of the patients in either group developed hypotension or bradycardia either in intraoperative period or post-operative period. Post-operative VAS scores were comparable in both groups [Figure 3].

Bottom Line: Adverse effects if any were noted.No other side effects were observed.Intrathecal DMT 3 μg dose does not produce faster ambulation compared to intrathecal DMT 5 μg though it produces comparable duration of analgesia for perianal surgeries.

View Article: PubMed Central - PubMed

Affiliation: Department of Anaesthesiology, Bangalore Medical College and Research Institute, Bengaluru, Karnataka, India.

ABSTRACT

Background and aims: Dexmedetomidine (DMT), as intrathecal adjuvant has been shown to successfully prolong duration of analgesia but delay the motor recovery. Hence, this study was designed to find out the dose of DMT which can provide satisfactory analgesia without prolonging motor block.

Methods: A total of 50 patients scheduled for elective perianal surgeries were randomly allocated to Groups C or D (n = 25). Group D received hyperbaric bupivacaine 0.5% 4 mg + DMT 5 μg and Group C received hyperbaric bupivacaine 0.5% 4 mg + DMT 3 μg intrathecally. Onset and duration of sensory and motor blockade, duration of analgesia, time for ambulation and first urination were recorded. Adverse effects if any were noted.

Results: Demographic characters, duration of surgery were comparable. The onset of sensory block to S1 was 9.61 ± 5.53 min in Group C compared to 7.69 ± 4.80 min in Group D (P = 0.35). Duration of sensory (145.28 ± 83.17 min - C, 167.85 ± 93.75 min - D, P = 0.5) and motor block (170.53 ± 73.44 min - C, 196.14 ± 84.28 min, P = 0.39) were comparable. Duration of analgesia (337.86 ± 105.11 min - C, 340.78 ± 101.81 min - D, P = 0.9) and time for ambulation (252.46 ± 93.72 min - C, 253.64 ± 88.04 min - D, P = 0.97) were also comparable. One patient in each group had urinary retention requiring catheterization. No other side effects were observed.

Conclusion: Intrathecal DMT 3 μg dose does not produce faster ambulation compared to intrathecal DMT 5 μg though it produces comparable duration of analgesia for perianal surgeries.

No MeSH data available.