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Complications of sequential immunotherapy in metastatic melanoma

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Targeted therapy and immunotherapy are mainstays of treatment... Here we present a case of a patient with metastatic melanoma who developed rhabdomyolysis and vitiligo after various courses of immunotherapy... A muscle biopsy was consistent with necrotizing myopathy with macrophage and T cell infiltration... Repeat imaging two months later revealed resolution of axillary lymphadenopathy and lung nodules that decreased in size... He was noted to have new onset diffuse vitiligo... The complications of sequential immunotherapy in metastatic melanoma has not been well described... It is unclear if previous immunotherapy, especially genetically engineered T cells, contributed to this unusual toxicity... Ultimately our patient experienced a favorable clinical response as evidenced by the development of vitiligo and decrease in his tumor burden... Physicians should be alert for rare and unexpected toxicities in patients who have received multiple lines of immunotherapy... Written informed consent was obtained from the patient for publication of this abstract and any accompanying images... A copy of the writen consent is available for review.

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Complications of sequential immunotherapy in metastatic melanoma
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4645284&req=5

View Article: PubMed Central - HTML

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Targeted therapy and immunotherapy are mainstays of treatment... Here we present a case of a patient with metastatic melanoma who developed rhabdomyolysis and vitiligo after various courses of immunotherapy... A muscle biopsy was consistent with necrotizing myopathy with macrophage and T cell infiltration... Repeat imaging two months later revealed resolution of axillary lymphadenopathy and lung nodules that decreased in size... He was noted to have new onset diffuse vitiligo... The complications of sequential immunotherapy in metastatic melanoma has not been well described... It is unclear if previous immunotherapy, especially genetically engineered T cells, contributed to this unusual toxicity... Ultimately our patient experienced a favorable clinical response as evidenced by the development of vitiligo and decrease in his tumor burden... Physicians should be alert for rare and unexpected toxicities in patients who have received multiple lines of immunotherapy... Written informed consent was obtained from the patient for publication of this abstract and any accompanying images... A copy of the writen consent is available for review.

No MeSH data available.