A controlled antibiotic release system to prevent orthopedic-implant associated infections: An in vitro study.
Bottom Line: A new device for local delivery of antibiotics is presented, with potential use as a drug-eluting fixation pin for orthopedic applications.Depending on the antibiotic chosen and the number of orifices, the release profile can be tailored from a rapid release of the load (ca. 20h) to a combination of rapid initial release and slower, sustained release for a longer period of time (ca. 200h).An excellent bactericidal action is obtained, with 4-log reductions achieved in as little as 2h, and total bacterial eradication in 8h using 6-pinholed implants filled with cefazolin.
Affiliation: Department of Animal Pathology, University of Zaragoza, C/ Miguel Servet, 177, 50013 Zaragoza, Spain.Show MeSH
Mentions: Both loaded implants showed a strong bactericidal effect after short exposure times (complete bacterial eradication after 24 and 8 h for linezolid and cefazolin-loaded implants, respectively, Fig. 5). The control implant exhibited a linear bacterial growth for linezolid and cefazolin experiments, reaching values around 1010 CFU/ml after 48 h of incubation.
Affiliation: Department of Animal Pathology, University of Zaragoza, C/ Miguel Servet, 177, 50013 Zaragoza, Spain.