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A controlled antibiotic release system to prevent orthopedic-implant associated infections: An in vitro study.

Gimeno M, Pinczowski P, Pérez M, Giorello A, Martínez MÁ, Santamaría J, Arruebo M, Luján L - Eur J Pharm Biopharm (2015)

Bottom Line: A new device for local delivery of antibiotics is presented, with potential use as a drug-eluting fixation pin for orthopedic applications.Depending on the antibiotic chosen and the number of orifices, the release profile can be tailored from a rapid release of the load (ca. 20h) to a combination of rapid initial release and slower, sustained release for a longer period of time (ca. 200h).An excellent bactericidal action is obtained, with 4-log reductions achieved in as little as 2h, and total bacterial eradication in 8h using 6-pinholed implants filled with cefazolin.

View Article: PubMed Central - PubMed

Affiliation: Department of Animal Pathology, University of Zaragoza, C/ Miguel Servet, 177, 50013 Zaragoza, Spain.

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Kinetics of the bactericidal action for four and six pinholed implants in a 48 h experiment.
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f0025: Kinetics of the bactericidal action for four and six pinholed implants in a 48 h experiment.

Mentions: Both loaded implants showed a strong bactericidal effect after short exposure times (complete bacterial eradication after 24 and 8 h for linezolid and cefazolin-loaded implants, respectively, Fig. 5). The control implant exhibited a linear bacterial growth for linezolid and cefazolin experiments, reaching values around 1010 CFU/ml after 48 h of incubation.


A controlled antibiotic release system to prevent orthopedic-implant associated infections: An in vitro study.

Gimeno M, Pinczowski P, Pérez M, Giorello A, Martínez MÁ, Santamaría J, Arruebo M, Luján L - Eur J Pharm Biopharm (2015)

Kinetics of the bactericidal action for four and six pinholed implants in a 48 h experiment.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4644989&req=5

f0025: Kinetics of the bactericidal action for four and six pinholed implants in a 48 h experiment.
Mentions: Both loaded implants showed a strong bactericidal effect after short exposure times (complete bacterial eradication after 24 and 8 h for linezolid and cefazolin-loaded implants, respectively, Fig. 5). The control implant exhibited a linear bacterial growth for linezolid and cefazolin experiments, reaching values around 1010 CFU/ml after 48 h of incubation.

Bottom Line: A new device for local delivery of antibiotics is presented, with potential use as a drug-eluting fixation pin for orthopedic applications.Depending on the antibiotic chosen and the number of orifices, the release profile can be tailored from a rapid release of the load (ca. 20h) to a combination of rapid initial release and slower, sustained release for a longer period of time (ca. 200h).An excellent bactericidal action is obtained, with 4-log reductions achieved in as little as 2h, and total bacterial eradication in 8h using 6-pinholed implants filled with cefazolin.

View Article: PubMed Central - PubMed

Affiliation: Department of Animal Pathology, University of Zaragoza, C/ Miguel Servet, 177, 50013 Zaragoza, Spain.

Show MeSH