A controlled antibiotic release system to prevent orthopedic-implant associated infections: An in vitro study.
Bottom Line: A new device for local delivery of antibiotics is presented, with potential use as a drug-eluting fixation pin for orthopedic applications.Depending on the antibiotic chosen and the number of orifices, the release profile can be tailored from a rapid release of the load (ca. 20h) to a combination of rapid initial release and slower, sustained release for a longer period of time (ca. 200h).An excellent bactericidal action is obtained, with 4-log reductions achieved in as little as 2h, and total bacterial eradication in 8h using 6-pinholed implants filled with cefazolin.
Affiliation: Department of Animal Pathology, University of Zaragoza, C/ Miguel Servet, 177, 50013 Zaragoza, Spain.Show MeSH
Affiliation: Department of Animal Pathology, University of Zaragoza, C/ Miguel Servet, 177, 50013 Zaragoza, Spain.