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Effect of extramucin pools in gastric cancer patients.

Kim KH, Lee SH, Choi CW, Kim SJ, Choi CI, Kim DH, Jeon TY, Kim DH, Hwang SH - Ann Surg Treat Res (2015)

Bottom Line: We compared MGC versus nonmucinous gastric adenocarcinoma (NMGC).LEMPC patients showed similar features compared with NMGC patients.It is reasonable to consider LEMPC patients in the diagnostic criteria of MGC, and to adequately treat.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Pusan National University Yangsan Hospital, Yangsan, Korea.

ABSTRACT

Purpose: Mucinous gastric adenocarcinoma (MGC) is defined by the World Health Organization as a gastric adenocarcinoma with >50% extracellular mucin pools within the tumors. In this study, we attempted to analyze the clinicopathologic features of patients pathologically diagnosed as gastric cancer with lower than 50% tumor volume of extracellular mucin pool adenocarcinoma (LEMPC). We compared MGC versus nonmucinous gastric adenocarcinoma (NMGC). We were used in abbreviations LEMPC for NMGC including extracellular mucin pool.

Methods: Files of 995 patients with gastric cancer NMGC (n = 935), MGC (n = 20), LEMPC (n = 40) who underwent curative resection at Pusan National University Yangsan Hospital from December 2008 to December 2013 were retrospectively analyzed. All pathologic reports after curative resection and evaluated clinicopathologic features were reviewed to identify the effect of extracellular mucin pools in gastric cancer.

Results: Compared with the NMGC patients, the clinicopathological features of MGC patients were as follows: more frequent open surgery, larger tumor size, more advanced T stage and N stage, more positive lymph node metastasis, and perineural invasion. LEMPC patients showed similar features compared with NMGC patients. MGC and LEMPC patients showed similar clinicopathological features, except T stage and lymph node metastasis.

Conclusion: LEMPC can be thought of as a previous step of MGC. It is reasonable to consider LEMPC patients in the diagnostic criteria of MGC, and to adequately treat.

No MeSH data available.


Related in: MedlinePlus

Extracellular mucin pools are lower than one half of the tumor area (A, Hematoxylin and eosin stain ×20) and mucinous gastric adenocarcinoma (B, Hematoxylin and eosin stain).
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Figure 1: Extracellular mucin pools are lower than one half of the tumor area (A, Hematoxylin and eosin stain ×20) and mucinous gastric adenocarcinoma (B, Hematoxylin and eosin stain).

Mentions: Clinically, it is possible to find cases with extracellular mucin pools lower than a half of the tumor area (Fig. 1). However, the exact prevalence rate is unknown. It could be missing from the pathologic report because gastric cancer with lower than 50% tumor volume of extracellular mucin pool adenocarcinoma (LEMPC) is not included in the diagnostic criteria of WHO classification. Moreover, if a pathologist is not aware of LEMPC, extracellular mucin pools may be overlooked. According to the WHO classification, those cases are classified as NMGC, not MGC. Treatment of LEMPC is similar to that of NMGC, even though LEMPC tends to be more progressive [9].


Effect of extramucin pools in gastric cancer patients.

Kim KH, Lee SH, Choi CW, Kim SJ, Choi CI, Kim DH, Jeon TY, Kim DH, Hwang SH - Ann Surg Treat Res (2015)

Extracellular mucin pools are lower than one half of the tumor area (A, Hematoxylin and eosin stain ×20) and mucinous gastric adenocarcinoma (B, Hematoxylin and eosin stain).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4644906&req=5

Figure 1: Extracellular mucin pools are lower than one half of the tumor area (A, Hematoxylin and eosin stain ×20) and mucinous gastric adenocarcinoma (B, Hematoxylin and eosin stain).
Mentions: Clinically, it is possible to find cases with extracellular mucin pools lower than a half of the tumor area (Fig. 1). However, the exact prevalence rate is unknown. It could be missing from the pathologic report because gastric cancer with lower than 50% tumor volume of extracellular mucin pool adenocarcinoma (LEMPC) is not included in the diagnostic criteria of WHO classification. Moreover, if a pathologist is not aware of LEMPC, extracellular mucin pools may be overlooked. According to the WHO classification, those cases are classified as NMGC, not MGC. Treatment of LEMPC is similar to that of NMGC, even though LEMPC tends to be more progressive [9].

Bottom Line: We compared MGC versus nonmucinous gastric adenocarcinoma (NMGC).LEMPC patients showed similar features compared with NMGC patients.It is reasonable to consider LEMPC patients in the diagnostic criteria of MGC, and to adequately treat.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Pusan National University Yangsan Hospital, Yangsan, Korea.

ABSTRACT

Purpose: Mucinous gastric adenocarcinoma (MGC) is defined by the World Health Organization as a gastric adenocarcinoma with >50% extracellular mucin pools within the tumors. In this study, we attempted to analyze the clinicopathologic features of patients pathologically diagnosed as gastric cancer with lower than 50% tumor volume of extracellular mucin pool adenocarcinoma (LEMPC). We compared MGC versus nonmucinous gastric adenocarcinoma (NMGC). We were used in abbreviations LEMPC for NMGC including extracellular mucin pool.

Methods: Files of 995 patients with gastric cancer NMGC (n = 935), MGC (n = 20), LEMPC (n = 40) who underwent curative resection at Pusan National University Yangsan Hospital from December 2008 to December 2013 were retrospectively analyzed. All pathologic reports after curative resection and evaluated clinicopathologic features were reviewed to identify the effect of extracellular mucin pools in gastric cancer.

Results: Compared with the NMGC patients, the clinicopathological features of MGC patients were as follows: more frequent open surgery, larger tumor size, more advanced T stage and N stage, more positive lymph node metastasis, and perineural invasion. LEMPC patients showed similar features compared with NMGC patients. MGC and LEMPC patients showed similar clinicopathological features, except T stage and lymph node metastasis.

Conclusion: LEMPC can be thought of as a previous step of MGC. It is reasonable to consider LEMPC patients in the diagnostic criteria of MGC, and to adequately treat.

No MeSH data available.


Related in: MedlinePlus