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Intake of Meals Containing High Levels of Carbohydrates or High Levels of Unsaturated Fatty Acids Induces Postprandial Dysmetabolism in Young Overweight/Obese Men.

Adamska E, Ostrowska L, Gościk J, Waszczeniuk M, Krętowski A, Górska M - Biomed Res Int (2015)

Bottom Line: Group I received high- and normal-carbohydrate meals, whereas group II received high-carbohydrate and high-fat meals.Glucose, insulin, triglyceride, and free fatty acids levels were measured at fasting state and at 30, 60, 120, 180, and 240 minutes after meal intake.TG and FFA levels were higher after normal-carbohydrate and high-fat meals.

View Article: PubMed Central - PubMed

Affiliation: Clinical Research Centre, Medical University of Bialystok, M.C. Skłodowskiej-Curie 24A, 15-276 Bialystok, Poland.

ABSTRACT
Postprandial metabolic response depends on the meals' components and can be different in normal weight and obese people. However, there are some discrepancies between various reports. The aim of this study was to determine the metabolic response after intake of standardised meals with various fat and carbohydrate contents and to determine the differences among normal weight and overweight/obese individuals. The study group comprised 46 healthy men. The participants were divided into two groups and study was carried out using a crossover method. Group I received high- and normal-carbohydrate meals, whereas group II received high-carbohydrate and high-fat meals. Glucose, insulin, triglyceride, and free fatty acids levels were measured at fasting state and at 30, 60, 120, 180, and 240 minutes after meal intake. Despite the lack of differences in glucose levels, insulin levels were higher among overweight/obese individuals after each meal. TG and FFA levels were higher after normal-carbohydrate and high-fat meals. Moreover, in overweight/obese young men after high-fat meal intake postprandial hypertriglyceridemia was observed, even if meals contained predominantly unsaturated fatty acids, and fasting triglycerides levels were in normal range. The conducted study showed that postprandial metabolic response depends not only on the meal macronutrient content but also on the current body mass index (BMI).

No MeSH data available.


Related in: MedlinePlus

Free fatty acids (FFAs) levels (μmol/L) in normal weight (NW) and overweight/obese (OO) men in fasting state (time 0 min) and after (time 30–240 min): (a) high-carbohydrate (HC, black circle) and normal-carbohydrate (NC, white square) meal intake. (b) High-carbohydrate (HC, black circle) and high-fat (HF, white triangle) meal intake. Data are presented as a mean value ± SE. Comparison between different meals in NW or OO men: ∗P < 0.05, ∗∗P < 0.01, and ∗∗∗P < 0.001. Comparison between NW and OO men after the same meal intake: AP < 0.05, BP < 0.01, and CP < 0.001.
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fig5: Free fatty acids (FFAs) levels (μmol/L) in normal weight (NW) and overweight/obese (OO) men in fasting state (time 0 min) and after (time 30–240 min): (a) high-carbohydrate (HC, black circle) and normal-carbohydrate (NC, white square) meal intake. (b) High-carbohydrate (HC, black circle) and high-fat (HF, white triangle) meal intake. Data are presented as a mean value ± SE. Comparison between different meals in NW or OO men: ∗P < 0.05, ∗∗P < 0.01, and ∗∗∗P < 0.001. Comparison between NW and OO men after the same meal intake: AP < 0.05, BP < 0.01, and CP < 0.001.

Mentions: Both, in NW and in OO men, the FFAs levels were significantly higher from 120 to 240 minutes after NC meal intake, in comparison to the levels after HC meal (Figure 5(a)). Moreover, the AUCs for FFAs levels after NC meal were significantly higher than those after HC meal in NW (103435 ± 12984 versus 74272 ± 12380, resp., P < 0.03) and OO men (108645 ± 10686 versus 65846 ± 7378, resp., P < 0.0001). The differences were more distinct after HF meal intake, when for 30 minutes of testing the FFAs levels were higher in comparison to FFAs levels after HC meal intake, among NW and OO men (Figure 5(b)). The AUCs for FFAs levels were significantly higher after HF meal than after HC meal in NW (133630 ± 6336 versus 38960 ± 5120, resp., P < 0.000001) and OO individuals (196624 ± 18147 versus 60300 ± 10017, resp., P < 0.0001).


Intake of Meals Containing High Levels of Carbohydrates or High Levels of Unsaturated Fatty Acids Induces Postprandial Dysmetabolism in Young Overweight/Obese Men.

Adamska E, Ostrowska L, Gościk J, Waszczeniuk M, Krętowski A, Górska M - Biomed Res Int (2015)

Free fatty acids (FFAs) levels (μmol/L) in normal weight (NW) and overweight/obese (OO) men in fasting state (time 0 min) and after (time 30–240 min): (a) high-carbohydrate (HC, black circle) and normal-carbohydrate (NC, white square) meal intake. (b) High-carbohydrate (HC, black circle) and high-fat (HF, white triangle) meal intake. Data are presented as a mean value ± SE. Comparison between different meals in NW or OO men: ∗P < 0.05, ∗∗P < 0.01, and ∗∗∗P < 0.001. Comparison between NW and OO men after the same meal intake: AP < 0.05, BP < 0.01, and CP < 0.001.
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Related In: Results  -  Collection

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Show All Figures
getmorefigures.php?uid=PMC4644820&req=5

fig5: Free fatty acids (FFAs) levels (μmol/L) in normal weight (NW) and overweight/obese (OO) men in fasting state (time 0 min) and after (time 30–240 min): (a) high-carbohydrate (HC, black circle) and normal-carbohydrate (NC, white square) meal intake. (b) High-carbohydrate (HC, black circle) and high-fat (HF, white triangle) meal intake. Data are presented as a mean value ± SE. Comparison between different meals in NW or OO men: ∗P < 0.05, ∗∗P < 0.01, and ∗∗∗P < 0.001. Comparison between NW and OO men after the same meal intake: AP < 0.05, BP < 0.01, and CP < 0.001.
Mentions: Both, in NW and in OO men, the FFAs levels were significantly higher from 120 to 240 minutes after NC meal intake, in comparison to the levels after HC meal (Figure 5(a)). Moreover, the AUCs for FFAs levels after NC meal were significantly higher than those after HC meal in NW (103435 ± 12984 versus 74272 ± 12380, resp., P < 0.03) and OO men (108645 ± 10686 versus 65846 ± 7378, resp., P < 0.0001). The differences were more distinct after HF meal intake, when for 30 minutes of testing the FFAs levels were higher in comparison to FFAs levels after HC meal intake, among NW and OO men (Figure 5(b)). The AUCs for FFAs levels were significantly higher after HF meal than after HC meal in NW (133630 ± 6336 versus 38960 ± 5120, resp., P < 0.000001) and OO individuals (196624 ± 18147 versus 60300 ± 10017, resp., P < 0.0001).

Bottom Line: Group I received high- and normal-carbohydrate meals, whereas group II received high-carbohydrate and high-fat meals.Glucose, insulin, triglyceride, and free fatty acids levels were measured at fasting state and at 30, 60, 120, 180, and 240 minutes after meal intake.TG and FFA levels were higher after normal-carbohydrate and high-fat meals.

View Article: PubMed Central - PubMed

Affiliation: Clinical Research Centre, Medical University of Bialystok, M.C. Skłodowskiej-Curie 24A, 15-276 Bialystok, Poland.

ABSTRACT
Postprandial metabolic response depends on the meals' components and can be different in normal weight and obese people. However, there are some discrepancies between various reports. The aim of this study was to determine the metabolic response after intake of standardised meals with various fat and carbohydrate contents and to determine the differences among normal weight and overweight/obese individuals. The study group comprised 46 healthy men. The participants were divided into two groups and study was carried out using a crossover method. Group I received high- and normal-carbohydrate meals, whereas group II received high-carbohydrate and high-fat meals. Glucose, insulin, triglyceride, and free fatty acids levels were measured at fasting state and at 30, 60, 120, 180, and 240 minutes after meal intake. Despite the lack of differences in glucose levels, insulin levels were higher among overweight/obese individuals after each meal. TG and FFA levels were higher after normal-carbohydrate and high-fat meals. Moreover, in overweight/obese young men after high-fat meal intake postprandial hypertriglyceridemia was observed, even if meals contained predominantly unsaturated fatty acids, and fasting triglycerides levels were in normal range. The conducted study showed that postprandial metabolic response depends not only on the meal macronutrient content but also on the current body mass index (BMI).

No MeSH data available.


Related in: MedlinePlus