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Intake of Meals Containing High Levels of Carbohydrates or High Levels of Unsaturated Fatty Acids Induces Postprandial Dysmetabolism in Young Overweight/Obese Men.

Adamska E, Ostrowska L, Gościk J, Waszczeniuk M, Krętowski A, Górska M - Biomed Res Int (2015)

Bottom Line: Group I received high- and normal-carbohydrate meals, whereas group II received high-carbohydrate and high-fat meals.Glucose, insulin, triglyceride, and free fatty acids levels were measured at fasting state and at 30, 60, 120, 180, and 240 minutes after meal intake.TG and FFA levels were higher after normal-carbohydrate and high-fat meals.

View Article: PubMed Central - PubMed

Affiliation: Clinical Research Centre, Medical University of Bialystok, M.C. Skłodowskiej-Curie 24A, 15-276 Bialystok, Poland.

ABSTRACT
Postprandial metabolic response depends on the meals' components and can be different in normal weight and obese people. However, there are some discrepancies between various reports. The aim of this study was to determine the metabolic response after intake of standardised meals with various fat and carbohydrate contents and to determine the differences among normal weight and overweight/obese individuals. The study group comprised 46 healthy men. The participants were divided into two groups and study was carried out using a crossover method. Group I received high- and normal-carbohydrate meals, whereas group II received high-carbohydrate and high-fat meals. Glucose, insulin, triglyceride, and free fatty acids levels were measured at fasting state and at 30, 60, 120, 180, and 240 minutes after meal intake. Despite the lack of differences in glucose levels, insulin levels were higher among overweight/obese individuals after each meal. TG and FFA levels were higher after normal-carbohydrate and high-fat meals. Moreover, in overweight/obese young men after high-fat meal intake postprandial hypertriglyceridemia was observed, even if meals contained predominantly unsaturated fatty acids, and fasting triglycerides levels were in normal range. The conducted study showed that postprandial metabolic response depends not only on the meal macronutrient content but also on the current body mass index (BMI).

No MeSH data available.


Related in: MedlinePlus

Insulin levels (IU/mL) in normal weight (NW) and overweight/obese (OO) men in fasting state (time 0 min) and after (time 30–240 min): (a) high-carbohydrate (HC, black circle) and normal-carbohydrate (NC, white square) meal intake. (b) High-carbohydrate (HC, black circle) and high-fat (HF, white triangle) meal intake. Data are presented as a mean value ± SE. Comparison between different meals in NW or OO men: ∗P < 0.05, ∗∗P < 0.01, and ∗∗∗P < 0.001. Comparison between NW and OO men after the same meal intake: AP < 0.05, BP < 0.01, and CP < 0.001.
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fig3: Insulin levels (IU/mL) in normal weight (NW) and overweight/obese (OO) men in fasting state (time 0 min) and after (time 30–240 min): (a) high-carbohydrate (HC, black circle) and normal-carbohydrate (NC, white square) meal intake. (b) High-carbohydrate (HC, black circle) and high-fat (HF, white triangle) meal intake. Data are presented as a mean value ± SE. Comparison between different meals in NW or OO men: ∗P < 0.05, ∗∗P < 0.01, and ∗∗∗P < 0.001. Comparison between NW and OO men after the same meal intake: AP < 0.05, BP < 0.01, and CP < 0.001.

Mentions: The insulin levels were significantly higher after HC meal in comparison to NC meal, both in NW and in OO men (Figure 3(a)). The insulin levels were significantly higher from 60 to 180 minutes in NW men and in OO men. The values of AUCs for insulin levels were significantly higher after HC meal in comparison to NC meal, both in NW (11047 ± 2162 versus 5694 ± 716, resp., P < 0.03) and in OO men (21999 ± 2917 versus 12845 ± 1712, resp., P < 0.001).


Intake of Meals Containing High Levels of Carbohydrates or High Levels of Unsaturated Fatty Acids Induces Postprandial Dysmetabolism in Young Overweight/Obese Men.

Adamska E, Ostrowska L, Gościk J, Waszczeniuk M, Krętowski A, Górska M - Biomed Res Int (2015)

Insulin levels (IU/mL) in normal weight (NW) and overweight/obese (OO) men in fasting state (time 0 min) and after (time 30–240 min): (a) high-carbohydrate (HC, black circle) and normal-carbohydrate (NC, white square) meal intake. (b) High-carbohydrate (HC, black circle) and high-fat (HF, white triangle) meal intake. Data are presented as a mean value ± SE. Comparison between different meals in NW or OO men: ∗P < 0.05, ∗∗P < 0.01, and ∗∗∗P < 0.001. Comparison between NW and OO men after the same meal intake: AP < 0.05, BP < 0.01, and CP < 0.001.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4644820&req=5

fig3: Insulin levels (IU/mL) in normal weight (NW) and overweight/obese (OO) men in fasting state (time 0 min) and after (time 30–240 min): (a) high-carbohydrate (HC, black circle) and normal-carbohydrate (NC, white square) meal intake. (b) High-carbohydrate (HC, black circle) and high-fat (HF, white triangle) meal intake. Data are presented as a mean value ± SE. Comparison between different meals in NW or OO men: ∗P < 0.05, ∗∗P < 0.01, and ∗∗∗P < 0.001. Comparison between NW and OO men after the same meal intake: AP < 0.05, BP < 0.01, and CP < 0.001.
Mentions: The insulin levels were significantly higher after HC meal in comparison to NC meal, both in NW and in OO men (Figure 3(a)). The insulin levels were significantly higher from 60 to 180 minutes in NW men and in OO men. The values of AUCs for insulin levels were significantly higher after HC meal in comparison to NC meal, both in NW (11047 ± 2162 versus 5694 ± 716, resp., P < 0.03) and in OO men (21999 ± 2917 versus 12845 ± 1712, resp., P < 0.001).

Bottom Line: Group I received high- and normal-carbohydrate meals, whereas group II received high-carbohydrate and high-fat meals.Glucose, insulin, triglyceride, and free fatty acids levels were measured at fasting state and at 30, 60, 120, 180, and 240 minutes after meal intake.TG and FFA levels were higher after normal-carbohydrate and high-fat meals.

View Article: PubMed Central - PubMed

Affiliation: Clinical Research Centre, Medical University of Bialystok, M.C. Skłodowskiej-Curie 24A, 15-276 Bialystok, Poland.

ABSTRACT
Postprandial metabolic response depends on the meals' components and can be different in normal weight and obese people. However, there are some discrepancies between various reports. The aim of this study was to determine the metabolic response after intake of standardised meals with various fat and carbohydrate contents and to determine the differences among normal weight and overweight/obese individuals. The study group comprised 46 healthy men. The participants were divided into two groups and study was carried out using a crossover method. Group I received high- and normal-carbohydrate meals, whereas group II received high-carbohydrate and high-fat meals. Glucose, insulin, triglyceride, and free fatty acids levels were measured at fasting state and at 30, 60, 120, 180, and 240 minutes after meal intake. Despite the lack of differences in glucose levels, insulin levels were higher among overweight/obese individuals after each meal. TG and FFA levels were higher after normal-carbohydrate and high-fat meals. Moreover, in overweight/obese young men after high-fat meal intake postprandial hypertriglyceridemia was observed, even if meals contained predominantly unsaturated fatty acids, and fasting triglycerides levels were in normal range. The conducted study showed that postprandial metabolic response depends not only on the meal macronutrient content but also on the current body mass index (BMI).

No MeSH data available.


Related in: MedlinePlus