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Hepatic and Splenic Acoustic Radiation Force Impulse Shear Wave Velocity Elastography in Children with Liver Disease Associated with Cystic Fibrosis.

Cañas T, Maciá A, Muñoz-Codoceo RA, Fontanilla T, González-Rios P, Miralles M, Gómez-Mardones G - Biomed Res Int (2015)

Bottom Line: We found a SWV RHL cut-off value to detect CFLD of 1.27 m/s with a sensitivity of 56.5% and a specificity of 90.5%.CF patients were found to have higher SWC spleen values than the control group.Conclusions.

View Article: PubMed Central - PubMed

Affiliation: Hospital Universitario Infantil Niño Jesús, 28009 Madrid, Spain.

ABSTRACT

Background: Liver disease associated with cystic fibrosis (CFLD) is the second cause of mortality in these patients. The diagnosis is difficult because none of the available tests are specific enough. Noninvasive elastographic techniques have been proven to be useful to diagnose hepatic fibrosis. Acoustic radiation force impulse (ARFI) imaging is an elastography imaging system. The purpose of the work was to study the utility of liver and spleen ARFI Imaging in the detection of CFLD. Method. 72 patients with cystic fibrosis (CF) were studied and received ARFI imaging in the liver and in the spleen. SWV values were compared with the values of 60 healthy controls. Results. Comparing the SWV values of CFLD with the control healthy group, values in the right lobe were higher in patients with CFLD. We found a SWV RHL cut-off value to detect CFLD of 1.27 m/s with a sensitivity of 56.5% and a specificity of 90.5%. CF patients were found to have higher SWC spleen values than the control group. Conclusions. ARFI shear wave elastography in the right hepatic lobe is a noninvasive technique useful to detect CFLD in our sample of patients. Splenic SWV values are higher in CF patients, without any clinical consequence.

No MeSH data available.


Related in: MedlinePlus

(a) Hepatic parenchyma altered structure: an expanded portal area is shown, with fibrous septa and hepatocytes enclosed in them. Inflammatory cells and ductular proliferation are seen, with positive Periodic Acid Schiff (PAS) content inside several proliferated biliary ducts. (b) Close-up view of the portal area in which four biliary ducts are seen (3 in the top half of the image and one in the lower half of the image) with PAS positive plugging inside. Images lent by Dr. Daniel Azorín, pathology department.
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fig3: (a) Hepatic parenchyma altered structure: an expanded portal area is shown, with fibrous septa and hepatocytes enclosed in them. Inflammatory cells and ductular proliferation are seen, with positive Periodic Acid Schiff (PAS) content inside several proliferated biliary ducts. (b) Close-up view of the portal area in which four biliary ducts are seen (3 in the top half of the image and one in the lower half of the image) with PAS positive plugging inside. Images lent by Dr. Daniel Azorín, pathology department.

Mentions: The histologic typical lesion is focal biliary fibrosis (Figure 3). Lesions may be confluent and eventually progress to multilobular cirrhosis. In it, lobules are not equally involved and relatively normal lobules can be found among involved ones. The left hepatic lobe may be more involved than the right one [2]. CFLD diagnosis is difficult and the use of hepatic biopsy is controverted, so noninvasive techniques are being investigated and used, among them elastographic techniques.


Hepatic and Splenic Acoustic Radiation Force Impulse Shear Wave Velocity Elastography in Children with Liver Disease Associated with Cystic Fibrosis.

Cañas T, Maciá A, Muñoz-Codoceo RA, Fontanilla T, González-Rios P, Miralles M, Gómez-Mardones G - Biomed Res Int (2015)

(a) Hepatic parenchyma altered structure: an expanded portal area is shown, with fibrous septa and hepatocytes enclosed in them. Inflammatory cells and ductular proliferation are seen, with positive Periodic Acid Schiff (PAS) content inside several proliferated biliary ducts. (b) Close-up view of the portal area in which four biliary ducts are seen (3 in the top half of the image and one in the lower half of the image) with PAS positive plugging inside. Images lent by Dr. Daniel Azorín, pathology department.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4644813&req=5

fig3: (a) Hepatic parenchyma altered structure: an expanded portal area is shown, with fibrous septa and hepatocytes enclosed in them. Inflammatory cells and ductular proliferation are seen, with positive Periodic Acid Schiff (PAS) content inside several proliferated biliary ducts. (b) Close-up view of the portal area in which four biliary ducts are seen (3 in the top half of the image and one in the lower half of the image) with PAS positive plugging inside. Images lent by Dr. Daniel Azorín, pathology department.
Mentions: The histologic typical lesion is focal biliary fibrosis (Figure 3). Lesions may be confluent and eventually progress to multilobular cirrhosis. In it, lobules are not equally involved and relatively normal lobules can be found among involved ones. The left hepatic lobe may be more involved than the right one [2]. CFLD diagnosis is difficult and the use of hepatic biopsy is controverted, so noninvasive techniques are being investigated and used, among them elastographic techniques.

Bottom Line: We found a SWV RHL cut-off value to detect CFLD of 1.27 m/s with a sensitivity of 56.5% and a specificity of 90.5%.CF patients were found to have higher SWC spleen values than the control group.Conclusions.

View Article: PubMed Central - PubMed

Affiliation: Hospital Universitario Infantil Niño Jesús, 28009 Madrid, Spain.

ABSTRACT

Background: Liver disease associated with cystic fibrosis (CFLD) is the second cause of mortality in these patients. The diagnosis is difficult because none of the available tests are specific enough. Noninvasive elastographic techniques have been proven to be useful to diagnose hepatic fibrosis. Acoustic radiation force impulse (ARFI) imaging is an elastography imaging system. The purpose of the work was to study the utility of liver and spleen ARFI Imaging in the detection of CFLD. Method. 72 patients with cystic fibrosis (CF) were studied and received ARFI imaging in the liver and in the spleen. SWV values were compared with the values of 60 healthy controls. Results. Comparing the SWV values of CFLD with the control healthy group, values in the right lobe were higher in patients with CFLD. We found a SWV RHL cut-off value to detect CFLD of 1.27 m/s with a sensitivity of 56.5% and a specificity of 90.5%. CF patients were found to have higher SWC spleen values than the control group. Conclusions. ARFI shear wave elastography in the right hepatic lobe is a noninvasive technique useful to detect CFLD in our sample of patients. Splenic SWV values are higher in CF patients, without any clinical consequence.

No MeSH data available.


Related in: MedlinePlus