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Hepatic and Splenic Acoustic Radiation Force Impulse Shear Wave Velocity Elastography in Children with Liver Disease Associated with Cystic Fibrosis.

Cañas T, Maciá A, Muñoz-Codoceo RA, Fontanilla T, González-Rios P, Miralles M, Gómez-Mardones G - Biomed Res Int (2015)

Bottom Line: We found a SWV RHL cut-off value to detect CFLD of 1.27 m/s with a sensitivity of 56.5% and a specificity of 90.5%.CF patients were found to have higher SWC spleen values than the control group.Conclusions.

View Article: PubMed Central - PubMed

Affiliation: Hospital Universitario Infantil Niño Jesús, 28009 Madrid, Spain.

ABSTRACT

Background: Liver disease associated with cystic fibrosis (CFLD) is the second cause of mortality in these patients. The diagnosis is difficult because none of the available tests are specific enough. Noninvasive elastographic techniques have been proven to be useful to diagnose hepatic fibrosis. Acoustic radiation force impulse (ARFI) imaging is an elastography imaging system. The purpose of the work was to study the utility of liver and spleen ARFI Imaging in the detection of CFLD. Method. 72 patients with cystic fibrosis (CF) were studied and received ARFI imaging in the liver and in the spleen. SWV values were compared with the values of 60 healthy controls. Results. Comparing the SWV values of CFLD with the control healthy group, values in the right lobe were higher in patients with CFLD. We found a SWV RHL cut-off value to detect CFLD of 1.27 m/s with a sensitivity of 56.5% and a specificity of 90.5%. CF patients were found to have higher SWC spleen values than the control group. Conclusions. ARFI shear wave elastography in the right hepatic lobe is a noninvasive technique useful to detect CFLD in our sample of patients. Splenic SWV values are higher in CF patients, without any clinical consequence.

No MeSH data available.


Related in: MedlinePlus

ROC curve for SWV in the RHL.
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fig2: ROC curve for SWV in the RHL.

Mentions: When we calculate the area under the ROC curve, we found a SWV RHL cut-off value to detect CFLD of 1.27 m/s, with a sensitivity of 56,5% and a specificity of 90,5% (Figure 2). The AUROC for SWV in the RHL was 0.746 P < 0.001 (95% CI 0.61–0.88). The AUROC curve (0.529) for SWV in the LHL was not significant.


Hepatic and Splenic Acoustic Radiation Force Impulse Shear Wave Velocity Elastography in Children with Liver Disease Associated with Cystic Fibrosis.

Cañas T, Maciá A, Muñoz-Codoceo RA, Fontanilla T, González-Rios P, Miralles M, Gómez-Mardones G - Biomed Res Int (2015)

ROC curve for SWV in the RHL.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4644813&req=5

fig2: ROC curve for SWV in the RHL.
Mentions: When we calculate the area under the ROC curve, we found a SWV RHL cut-off value to detect CFLD of 1.27 m/s, with a sensitivity of 56,5% and a specificity of 90,5% (Figure 2). The AUROC for SWV in the RHL was 0.746 P < 0.001 (95% CI 0.61–0.88). The AUROC curve (0.529) for SWV in the LHL was not significant.

Bottom Line: We found a SWV RHL cut-off value to detect CFLD of 1.27 m/s with a sensitivity of 56.5% and a specificity of 90.5%.CF patients were found to have higher SWC spleen values than the control group.Conclusions.

View Article: PubMed Central - PubMed

Affiliation: Hospital Universitario Infantil Niño Jesús, 28009 Madrid, Spain.

ABSTRACT

Background: Liver disease associated with cystic fibrosis (CFLD) is the second cause of mortality in these patients. The diagnosis is difficult because none of the available tests are specific enough. Noninvasive elastographic techniques have been proven to be useful to diagnose hepatic fibrosis. Acoustic radiation force impulse (ARFI) imaging is an elastography imaging system. The purpose of the work was to study the utility of liver and spleen ARFI Imaging in the detection of CFLD. Method. 72 patients with cystic fibrosis (CF) were studied and received ARFI imaging in the liver and in the spleen. SWV values were compared with the values of 60 healthy controls. Results. Comparing the SWV values of CFLD with the control healthy group, values in the right lobe were higher in patients with CFLD. We found a SWV RHL cut-off value to detect CFLD of 1.27 m/s with a sensitivity of 56.5% and a specificity of 90.5%. CF patients were found to have higher SWC spleen values than the control group. Conclusions. ARFI shear wave elastography in the right hepatic lobe is a noninvasive technique useful to detect CFLD in our sample of patients. Splenic SWV values are higher in CF patients, without any clinical consequence.

No MeSH data available.


Related in: MedlinePlus