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F-18 Fluoride Positron Emission Tomography-Computed Tomography for Detecting Atherosclerotic Plaques.

Kang WJ - Korean J Radiol (2015)

Bottom Line: A large number of major cardiovascular events occur in patients due to minimal or some lumen narrowing of the coronary artery.Recent biological studies have shown that the biological composition or vulnerability of the plaque is more critical for plaque rupture compared to the degree of stenosis.F-18 fluoride accumulates in regions of active microcalcification, which is normally observed during the early stages of plaque formation.

View Article: PubMed Central - PubMed

Affiliation: Department of Nuclear Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Korea.

ABSTRACT
A large number of major cardiovascular events occur in patients due to minimal or some lumen narrowing of the coronary artery. Recent biological studies have shown that the biological composition or vulnerability of the plaque is more critical for plaque rupture compared to the degree of stenosis. To overcome the limitations of anatomical images, molecular imaging techniques have been suggested as promising imaging tools in various fields. F-18 fluorodeoxyglucose (FDG), which is widely used in the field of oncology, is an example of molecular probes used in atherosclerotic plaque evaluation. FDG is a marker of plaque macrophage glucose utilization and inflammation, which is a prominent characteristic of vulnerable plaque. Recently, F-18 fluoride has been used to visualize vulnerable plaque in clinical studies. F-18 fluoride accumulates in regions of active microcalcification, which is normally observed during the early stages of plaque formation. More studies are warranted on the accumulation of F-18 fluoride and plaque formation/vulnerability; however, due to high specific accumulation, low background activity, and easy accessibility, F-18 fluoride is emerging as a promising non-invasive imaging probe to detect vulnerable plaque.

No MeSH data available.


Related in: MedlinePlus

F-18 fluoride PET-CT in 80-year-old male with stable angina.A. CT image shows similar calcifications in left circumflex artery (arrow) and left anterior descending artery (arrowhead). CT findings suggest that there is no difference in macrocalcification. B. F-18 fluoride PET shows high uptake at left circumflex artery (arrow) and mild uptake at left anterior descending artery (arrowhead). F-18 fluoride PET findings suggest that left circumflex artery has more microcalcification than left anterior descending artery, and has high probability for vulnerable plaque. C. PET-CT fusion image (Courtesy of Dr. Jin Chul Paeng in Seoul National University Hospital). PET = positron emission tomography
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Figure 1: F-18 fluoride PET-CT in 80-year-old male with stable angina.A. CT image shows similar calcifications in left circumflex artery (arrow) and left anterior descending artery (arrowhead). CT findings suggest that there is no difference in macrocalcification. B. F-18 fluoride PET shows high uptake at left circumflex artery (arrow) and mild uptake at left anterior descending artery (arrowhead). F-18 fluoride PET findings suggest that left circumflex artery has more microcalcification than left anterior descending artery, and has high probability for vulnerable plaque. C. PET-CT fusion image (Courtesy of Dr. Jin Chul Paeng in Seoul National University Hospital). PET = positron emission tomography

Mentions: Recently, F-18 fluoride PET was suggested as a promising imaging probe for atheromatous plaque imaging. F-18 fluoride ions accumulated in bone-forming fluoroapatite crystal by exchange of hydroxyl groups on hydroxyapatite surface (19). Similar to F-18 fluoride deposits in various active calcification sites, these ions may accumulate in vulnerable plaque (Fig. 1). In advanced calcified plaque, which is stable, and in the advanced stage, no deposition of F-18 fluoride may be observed.


F-18 Fluoride Positron Emission Tomography-Computed Tomography for Detecting Atherosclerotic Plaques.

Kang WJ - Korean J Radiol (2015)

F-18 fluoride PET-CT in 80-year-old male with stable angina.A. CT image shows similar calcifications in left circumflex artery (arrow) and left anterior descending artery (arrowhead). CT findings suggest that there is no difference in macrocalcification. B. F-18 fluoride PET shows high uptake at left circumflex artery (arrow) and mild uptake at left anterior descending artery (arrowhead). F-18 fluoride PET findings suggest that left circumflex artery has more microcalcification than left anterior descending artery, and has high probability for vulnerable plaque. C. PET-CT fusion image (Courtesy of Dr. Jin Chul Paeng in Seoul National University Hospital). PET = positron emission tomography
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4644746&req=5

Figure 1: F-18 fluoride PET-CT in 80-year-old male with stable angina.A. CT image shows similar calcifications in left circumflex artery (arrow) and left anterior descending artery (arrowhead). CT findings suggest that there is no difference in macrocalcification. B. F-18 fluoride PET shows high uptake at left circumflex artery (arrow) and mild uptake at left anterior descending artery (arrowhead). F-18 fluoride PET findings suggest that left circumflex artery has more microcalcification than left anterior descending artery, and has high probability for vulnerable plaque. C. PET-CT fusion image (Courtesy of Dr. Jin Chul Paeng in Seoul National University Hospital). PET = positron emission tomography
Mentions: Recently, F-18 fluoride PET was suggested as a promising imaging probe for atheromatous plaque imaging. F-18 fluoride ions accumulated in bone-forming fluoroapatite crystal by exchange of hydroxyl groups on hydroxyapatite surface (19). Similar to F-18 fluoride deposits in various active calcification sites, these ions may accumulate in vulnerable plaque (Fig. 1). In advanced calcified plaque, which is stable, and in the advanced stage, no deposition of F-18 fluoride may be observed.

Bottom Line: A large number of major cardiovascular events occur in patients due to minimal or some lumen narrowing of the coronary artery.Recent biological studies have shown that the biological composition or vulnerability of the plaque is more critical for plaque rupture compared to the degree of stenosis.F-18 fluoride accumulates in regions of active microcalcification, which is normally observed during the early stages of plaque formation.

View Article: PubMed Central - PubMed

Affiliation: Department of Nuclear Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Korea.

ABSTRACT
A large number of major cardiovascular events occur in patients due to minimal or some lumen narrowing of the coronary artery. Recent biological studies have shown that the biological composition or vulnerability of the plaque is more critical for plaque rupture compared to the degree of stenosis. To overcome the limitations of anatomical images, molecular imaging techniques have been suggested as promising imaging tools in various fields. F-18 fluorodeoxyglucose (FDG), which is widely used in the field of oncology, is an example of molecular probes used in atherosclerotic plaque evaluation. FDG is a marker of plaque macrophage glucose utilization and inflammation, which is a prominent characteristic of vulnerable plaque. Recently, F-18 fluoride has been used to visualize vulnerable plaque in clinical studies. F-18 fluoride accumulates in regions of active microcalcification, which is normally observed during the early stages of plaque formation. More studies are warranted on the accumulation of F-18 fluoride and plaque formation/vulnerability; however, due to high specific accumulation, low background activity, and easy accessibility, F-18 fluoride is emerging as a promising non-invasive imaging probe to detect vulnerable plaque.

No MeSH data available.


Related in: MedlinePlus