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Systematic Review and Meta-Analysis of Studies Evaluating Diagnostic Test Accuracy: A Practical Review for Clinical Researchers-Part I. General Guidance and Tips.

Kim KW, Lee J, Choi SH, Huh J, Park SH - Korean J Radiol (2015)

Bottom Line: By means of objective evaluation of all available primary studies, these two processes generate an evidence-based systematic summary regarding a specific research topic.The methodology for systematic review and meta-analysis in DTA studies differs from that in therapeutic/interventional studies, and its content is still evolving.Here we review the overall process from a practical standpoint, which may serve as a reference for those who implement these methods.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05505, Korea.

ABSTRACT
In the field of diagnostic test accuracy (DTA), the use of systematic review and meta-analyses is steadily increasing. By means of objective evaluation of all available primary studies, these two processes generate an evidence-based systematic summary regarding a specific research topic. The methodology for systematic review and meta-analysis in DTA studies differs from that in therapeutic/interventional studies, and its content is still evolving. Here we review the overall process from a practical standpoint, which may serve as a reference for those who implement these methods.

No MeSH data available.


Templates for presenting results of QUADAS-2 assessment for assessing quality of studies.We can present results of QUADAS-2 assessments in tabular form (A) or in graphics (B). QUADAS = Quality Assessment of Diagnostic Accuracy Studies
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Figure 3: Templates for presenting results of QUADAS-2 assessment for assessing quality of studies.We can present results of QUADAS-2 assessments in tabular form (A) or in graphics (B). QUADAS = Quality Assessment of Diagnostic Accuracy Studies

Mentions: The QUADAS-2 tool assesses study quality in four domains: patient selection, index test, reference standard, and flow and timing. Each domain is assessed in terms of the risk of bias and the applicability (i.e., generalizability) of the study results for the first three domains. Signaling questions are used to categorize the risk of bias as low, high, or unclear (19) and should be tailored to the questions for each systematic review because the eligible population, clinical setting, test protocol, and target disease may differ in each review. Although QUADAS-2 is the only validated tool for assessing the quality of studies, it does not include specific criteria for assessing comparative DTA studies, so this tool must be modified accordingly (20). Further details regarding QUADAS-2 can be found on its official website (http://www.bris.ac.uk/quadas/), which contains the QUADAS-2 tool and related documents, information about how to apply this tool, and examples of completed QUADAS-2 assessments. It also provides downloadable resources, including a Microsoft Access database for data extraction, an Excel spreadsheet to produce graphic displays of results, and templates for Word tables to summarize results (Fig. 3).


Systematic Review and Meta-Analysis of Studies Evaluating Diagnostic Test Accuracy: A Practical Review for Clinical Researchers-Part I. General Guidance and Tips.

Kim KW, Lee J, Choi SH, Huh J, Park SH - Korean J Radiol (2015)

Templates for presenting results of QUADAS-2 assessment for assessing quality of studies.We can present results of QUADAS-2 assessments in tabular form (A) or in graphics (B). QUADAS = Quality Assessment of Diagnostic Accuracy Studies
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4644738&req=5

Figure 3: Templates for presenting results of QUADAS-2 assessment for assessing quality of studies.We can present results of QUADAS-2 assessments in tabular form (A) or in graphics (B). QUADAS = Quality Assessment of Diagnostic Accuracy Studies
Mentions: The QUADAS-2 tool assesses study quality in four domains: patient selection, index test, reference standard, and flow and timing. Each domain is assessed in terms of the risk of bias and the applicability (i.e., generalizability) of the study results for the first three domains. Signaling questions are used to categorize the risk of bias as low, high, or unclear (19) and should be tailored to the questions for each systematic review because the eligible population, clinical setting, test protocol, and target disease may differ in each review. Although QUADAS-2 is the only validated tool for assessing the quality of studies, it does not include specific criteria for assessing comparative DTA studies, so this tool must be modified accordingly (20). Further details regarding QUADAS-2 can be found on its official website (http://www.bris.ac.uk/quadas/), which contains the QUADAS-2 tool and related documents, information about how to apply this tool, and examples of completed QUADAS-2 assessments. It also provides downloadable resources, including a Microsoft Access database for data extraction, an Excel spreadsheet to produce graphic displays of results, and templates for Word tables to summarize results (Fig. 3).

Bottom Line: By means of objective evaluation of all available primary studies, these two processes generate an evidence-based systematic summary regarding a specific research topic.The methodology for systematic review and meta-analysis in DTA studies differs from that in therapeutic/interventional studies, and its content is still evolving.Here we review the overall process from a practical standpoint, which may serve as a reference for those who implement these methods.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05505, Korea.

ABSTRACT
In the field of diagnostic test accuracy (DTA), the use of systematic review and meta-analyses is steadily increasing. By means of objective evaluation of all available primary studies, these two processes generate an evidence-based systematic summary regarding a specific research topic. The methodology for systematic review and meta-analysis in DTA studies differs from that in therapeutic/interventional studies, and its content is still evolving. Here we review the overall process from a practical standpoint, which may serve as a reference for those who implement these methods.

No MeSH data available.