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Systematic Review and Meta-Analysis of Studies Evaluating Diagnostic Test Accuracy: A Practical Review for Clinical Researchers-Part I. General Guidance and Tips.

Kim KW, Lee J, Choi SH, Huh J, Park SH - Korean J Radiol (2015)

Bottom Line: By means of objective evaluation of all available primary studies, these two processes generate an evidence-based systematic summary regarding a specific research topic.The methodology for systematic review and meta-analysis in DTA studies differs from that in therapeutic/interventional studies, and its content is still evolving.Here we review the overall process from a practical standpoint, which may serve as a reference for those who implement these methods.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05505, Korea.

ABSTRACT
In the field of diagnostic test accuracy (DTA), the use of systematic review and meta-analyses is steadily increasing. By means of objective evaluation of all available primary studies, these two processes generate an evidence-based systematic summary regarding a specific research topic. The methodology for systematic review and meta-analysis in DTA studies differs from that in therapeutic/interventional studies, and its content is still evolving. Here we review the overall process from a practical standpoint, which may serve as a reference for those who implement these methods.

No MeSH data available.


Related in: MedlinePlus

Diagram of study process and frame of research questions.DOR = diagnostic odds ratio, FN = false negative, FP = false positive, HCC = hepatocellular carcinoma, HSROC = hierarchical summary receiver operating characteristic, SROC = summary receiver operating characteristic, TN = true negative, TP = true positive
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Figure 1: Diagram of study process and frame of research questions.DOR = diagnostic odds ratio, FN = false negative, FP = false positive, HCC = hepatocellular carcinoma, HSROC = hierarchical summary receiver operating characteristic, SROC = summary receiver operating characteristic, TN = true negative, TP = true positive

Mentions: Clarifying the key research questions for the systematic review is the most important step in the entire review process. Each question should be clinically meaningful and based on a solid rationale and background. It is highly recommended that the questions be framed according to a structured framework (the so-called PICO format) (Table 2). For example, as illustrated in a recent study (7), if we want to explore whether or not magnetic resonance imaging (MRI) is superior to computed tomography (CT) for diagnosing hepatocellular carcinoma (HCC), we can frame the question within a structured form, as shown in Figure 1.


Systematic Review and Meta-Analysis of Studies Evaluating Diagnostic Test Accuracy: A Practical Review for Clinical Researchers-Part I. General Guidance and Tips.

Kim KW, Lee J, Choi SH, Huh J, Park SH - Korean J Radiol (2015)

Diagram of study process and frame of research questions.DOR = diagnostic odds ratio, FN = false negative, FP = false positive, HCC = hepatocellular carcinoma, HSROC = hierarchical summary receiver operating characteristic, SROC = summary receiver operating characteristic, TN = true negative, TP = true positive
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4644738&req=5

Figure 1: Diagram of study process and frame of research questions.DOR = diagnostic odds ratio, FN = false negative, FP = false positive, HCC = hepatocellular carcinoma, HSROC = hierarchical summary receiver operating characteristic, SROC = summary receiver operating characteristic, TN = true negative, TP = true positive
Mentions: Clarifying the key research questions for the systematic review is the most important step in the entire review process. Each question should be clinically meaningful and based on a solid rationale and background. It is highly recommended that the questions be framed according to a structured framework (the so-called PICO format) (Table 2). For example, as illustrated in a recent study (7), if we want to explore whether or not magnetic resonance imaging (MRI) is superior to computed tomography (CT) for diagnosing hepatocellular carcinoma (HCC), we can frame the question within a structured form, as shown in Figure 1.

Bottom Line: By means of objective evaluation of all available primary studies, these two processes generate an evidence-based systematic summary regarding a specific research topic.The methodology for systematic review and meta-analysis in DTA studies differs from that in therapeutic/interventional studies, and its content is still evolving.Here we review the overall process from a practical standpoint, which may serve as a reference for those who implement these methods.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05505, Korea.

ABSTRACT
In the field of diagnostic test accuracy (DTA), the use of systematic review and meta-analyses is steadily increasing. By means of objective evaluation of all available primary studies, these two processes generate an evidence-based systematic summary regarding a specific research topic. The methodology for systematic review and meta-analysis in DTA studies differs from that in therapeutic/interventional studies, and its content is still evolving. Here we review the overall process from a practical standpoint, which may serve as a reference for those who implement these methods.

No MeSH data available.


Related in: MedlinePlus