Limits...
Effect of Aerobic and Resistance Exercise Training on Liver Enzymes and Hepatic Fat in Iranian Men With Nonalcoholic Fatty Liver Disease.

Shamsoddini A, Sobhani V, Ghamar Chehreh ME, Alavian SM, Zaree A - Hepat Mon (2015)

Bottom Line: The current study aimed to investigate the effect of Aerobic Training (AT) and resistance training (RT) on hepatic fat content and liver enzyme levels in Iranian men.Moreover, body fat (%), fat mass (kg), homeostasis model assessment insulin resistance (HOMI-IR) were all improved in the AT and RT.This study demonstrated that RT and AT are equally effective in reducing hepatic fat content and liver enzyme levels among patients with NAFLD.

View Article: PubMed Central - PubMed

Affiliation: Exercise Physiology Research Center, Baqiyatallah University of Medical Sciences, Tehran, IR Iran.

ABSTRACT

Background: Nonalcoholic fatty liver disease (NAFLD) has different prevalence rates in various parts of the world and is a risk factor for diabetes and cardiovascular disease that could progress to nonalcoholic steatohepatitis, cirrhosis, and liver failure.

Objectives: The current study aimed to investigate the effect of Aerobic Training (AT) and resistance training (RT) on hepatic fat content and liver enzyme levels in Iranian men.

Patients and methods: In a randomized clinical trial study, 30 men with clinically defined NAFLD were allocated into three groups (aerobic, resistance and control). An aerobic group program consisted of 45 minutes of aerobic exercise at 60% - 75% maximum heart rate intensity, a resistance group performed seven resistance exercises at intensity of 50% - 70% of 1 repetition maximum (1RM ) and the control group had no exercise training program during the study. Before and after training, anthropometry, insulin sensitivity, liver enzymes and hepatic fat were elevated.

Results: After training, hepatic fat content was markedly reduced, to a similar extent, in both the aerobic and resistance exercise training groups (P ≤ 0.05). In the two exercise training groups, alanine amino transferase and aspartate amino transferase serum levels were significantly decreased compared to the control group (P = 0.002) and (P = 0.02), respectively. Moreover, body fat (%), fat mass (kg), homeostasis model assessment insulin resistance (HOMI-IR) were all improved in the AT and RT. These changes in the AT group were independent of weight loss.

Conclusions: This study demonstrated that RT and AT are equally effective in reducing hepatic fat content and liver enzyme levels among patients with NAFLD. However, aerobic exercise specifically improves NAFLD independent of any change in body weight.

No MeSH data available.


Related in: MedlinePlus

Hepatic Fat in Three Groups Before and After an Eight-Week InterventionData are presented as Mean ± SD; #, indicats P < 0.05 is significant.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4644631&req=5

fig23812: Hepatic Fat in Three Groups Before and After an Eight-Week InterventionData are presented as Mean ± SD; #, indicats P < 0.05 is significant.

Mentions: An informed consent was obtained from 30 patients and they were enrolled in the study. Table 1 shows anthropometric and body composition data of subjects with NAFLD before and after interventions. It was observed that aerobic and resistance groups presented significant improvement for anthropometric parameters. However, weight (kg) and BMI (kg/m2) were improved significantly only in the resistance exercise group. Repeated measure ANOVA analyses showed a significant difference regarding mean ALT, AST changes between the groups (Table 2). Post-hoc analyses showed significant differences in ALT, AST and hepatic fat between the control and aerobic groups, and the control and resistance groups (Table 3). Basal fatty liver that was diagnosed by sonography, after intervention, was significantly decreased in the aerobic and resistance exercise groups. However, in the control group, the liver fat content was slightly increased after 8weeks (Figure 1). Moreover, after training intervention, the aerobic group only presented significantly lower values of HOMA-IR compared to the control group (Figure 2).


Effect of Aerobic and Resistance Exercise Training on Liver Enzymes and Hepatic Fat in Iranian Men With Nonalcoholic Fatty Liver Disease.

Shamsoddini A, Sobhani V, Ghamar Chehreh ME, Alavian SM, Zaree A - Hepat Mon (2015)

Hepatic Fat in Three Groups Before and After an Eight-Week InterventionData are presented as Mean ± SD; #, indicats P < 0.05 is significant.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4644631&req=5

fig23812: Hepatic Fat in Three Groups Before and After an Eight-Week InterventionData are presented as Mean ± SD; #, indicats P < 0.05 is significant.
Mentions: An informed consent was obtained from 30 patients and they were enrolled in the study. Table 1 shows anthropometric and body composition data of subjects with NAFLD before and after interventions. It was observed that aerobic and resistance groups presented significant improvement for anthropometric parameters. However, weight (kg) and BMI (kg/m2) were improved significantly only in the resistance exercise group. Repeated measure ANOVA analyses showed a significant difference regarding mean ALT, AST changes between the groups (Table 2). Post-hoc analyses showed significant differences in ALT, AST and hepatic fat between the control and aerobic groups, and the control and resistance groups (Table 3). Basal fatty liver that was diagnosed by sonography, after intervention, was significantly decreased in the aerobic and resistance exercise groups. However, in the control group, the liver fat content was slightly increased after 8weeks (Figure 1). Moreover, after training intervention, the aerobic group only presented significantly lower values of HOMA-IR compared to the control group (Figure 2).

Bottom Line: The current study aimed to investigate the effect of Aerobic Training (AT) and resistance training (RT) on hepatic fat content and liver enzyme levels in Iranian men.Moreover, body fat (%), fat mass (kg), homeostasis model assessment insulin resistance (HOMI-IR) were all improved in the AT and RT.This study demonstrated that RT and AT are equally effective in reducing hepatic fat content and liver enzyme levels among patients with NAFLD.

View Article: PubMed Central - PubMed

Affiliation: Exercise Physiology Research Center, Baqiyatallah University of Medical Sciences, Tehran, IR Iran.

ABSTRACT

Background: Nonalcoholic fatty liver disease (NAFLD) has different prevalence rates in various parts of the world and is a risk factor for diabetes and cardiovascular disease that could progress to nonalcoholic steatohepatitis, cirrhosis, and liver failure.

Objectives: The current study aimed to investigate the effect of Aerobic Training (AT) and resistance training (RT) on hepatic fat content and liver enzyme levels in Iranian men.

Patients and methods: In a randomized clinical trial study, 30 men with clinically defined NAFLD were allocated into three groups (aerobic, resistance and control). An aerobic group program consisted of 45 minutes of aerobic exercise at 60% - 75% maximum heart rate intensity, a resistance group performed seven resistance exercises at intensity of 50% - 70% of 1 repetition maximum (1RM ) and the control group had no exercise training program during the study. Before and after training, anthropometry, insulin sensitivity, liver enzymes and hepatic fat were elevated.

Results: After training, hepatic fat content was markedly reduced, to a similar extent, in both the aerobic and resistance exercise training groups (P ≤ 0.05). In the two exercise training groups, alanine amino transferase and aspartate amino transferase serum levels were significantly decreased compared to the control group (P = 0.002) and (P = 0.02), respectively. Moreover, body fat (%), fat mass (kg), homeostasis model assessment insulin resistance (HOMI-IR) were all improved in the AT and RT. These changes in the AT group were independent of weight loss.

Conclusions: This study demonstrated that RT and AT are equally effective in reducing hepatic fat content and liver enzyme levels among patients with NAFLD. However, aerobic exercise specifically improves NAFLD independent of any change in body weight.

No MeSH data available.


Related in: MedlinePlus