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Efficacy of Zinc Sulfate as an Add-on Therapy to Risperidone Versus Risperidone Alone in Patients With Schizophrenia: A Double-Blind Randomized Placebo-Controlled Trial.

Mortazavi M, Farzin D, Zarhghami M, Hosseini SH, Mansoori P, Nateghi G - Iran J Psychiatry Behav Sci (2015)

Bottom Line: The results of this study showed that both protocols significantly decreased the scores on all subscales of the PANSS and supplemental aggression risk subscale as well as PANSS total score over the study.However, this improvement was significantly higher in Zn sulfate receiving group compared to the placebo group.No major clinical side-effects were detected.

View Article: PubMed Central - PubMed

Affiliation: Psychiatry and Behavioral Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, IR Iran.

ABSTRACT

Background: Zinc can modulate fast-excitatory transmission, facilitate the release of amino butyric acid and potentiate nicotinic acetylcholine receptors. There are also emerging evidences discussing the implication of these neurotransmitters in pathophysiology of schizophrenia.

Objectives: The purpose of this study was to evaluate the efficacy of Zn sulfate as an add-on therapy in the treatment of schizophrenia in a 6-week, double-blind and placebo-controlled trial.

Patients and methods: Eligible participants were 30 inpatients with schizophrenia according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision criteria. Patients were randomly allocated into two equal groups; one group of patients received risperidone 6 mg/day plus capsules of Zn sulfate (each containing 50 mg elemental Zn) three times a day and another group received risperidone 6 mg/day plus placebo. The Positive and Negative Syndrome Scale (PANSS) was applied to assess the psychotic symptoms and aggression risk at baseline, week 2, 4, and 6 of the study.

Results: The results of this study showed that both protocols significantly decreased the scores on all subscales of the PANSS and supplemental aggression risk subscale as well as PANSS total score over the study. However, this improvement was significantly higher in Zn sulfate receiving group compared to the placebo group. No major clinical side-effects were detected.

Conclusions: It may be concluded that Zn is an effective adjuvant agent in the management of patients with schizophrenia.

No MeSH data available.


Related in: MedlinePlus

Measures of Positive Scale of Positive and Negative Syndrome Scale Scores at Weeks 0, 2, 4, and 6Results are expressed as mean ± standard deviation. P = 0.007, P = 0.001, P = 0.040, different from control groups (* not significant).
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A853FIG2: Measures of Positive Scale of Positive and Negative Syndrome Scale Scores at Weeks 0, 2, 4, and 6Results are expressed as mean ± standard deviation. P = 0.007, P = 0.001, P = 0.040, different from control groups (* not significant).

Mentions: Moreover, there was no significant difference between the two groups at baseline regarding risk of aggression (P = 0.12). The differences between the two groups on the positive scale, negative scale, the general psychopathology scale, total PANSS score, and the PANSS supplemental aggression risk subscale scores are demonstrated in Figures 2 - 6, respectively.


Efficacy of Zinc Sulfate as an Add-on Therapy to Risperidone Versus Risperidone Alone in Patients With Schizophrenia: A Double-Blind Randomized Placebo-Controlled Trial.

Mortazavi M, Farzin D, Zarhghami M, Hosseini SH, Mansoori P, Nateghi G - Iran J Psychiatry Behav Sci (2015)

Measures of Positive Scale of Positive and Negative Syndrome Scale Scores at Weeks 0, 2, 4, and 6Results are expressed as mean ± standard deviation. P = 0.007, P = 0.001, P = 0.040, different from control groups (* not significant).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4644625&req=5

A853FIG2: Measures of Positive Scale of Positive and Negative Syndrome Scale Scores at Weeks 0, 2, 4, and 6Results are expressed as mean ± standard deviation. P = 0.007, P = 0.001, P = 0.040, different from control groups (* not significant).
Mentions: Moreover, there was no significant difference between the two groups at baseline regarding risk of aggression (P = 0.12). The differences between the two groups on the positive scale, negative scale, the general psychopathology scale, total PANSS score, and the PANSS supplemental aggression risk subscale scores are demonstrated in Figures 2 - 6, respectively.

Bottom Line: The results of this study showed that both protocols significantly decreased the scores on all subscales of the PANSS and supplemental aggression risk subscale as well as PANSS total score over the study.However, this improvement was significantly higher in Zn sulfate receiving group compared to the placebo group.No major clinical side-effects were detected.

View Article: PubMed Central - PubMed

Affiliation: Psychiatry and Behavioral Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, IR Iran.

ABSTRACT

Background: Zinc can modulate fast-excitatory transmission, facilitate the release of amino butyric acid and potentiate nicotinic acetylcholine receptors. There are also emerging evidences discussing the implication of these neurotransmitters in pathophysiology of schizophrenia.

Objectives: The purpose of this study was to evaluate the efficacy of Zn sulfate as an add-on therapy in the treatment of schizophrenia in a 6-week, double-blind and placebo-controlled trial.

Patients and methods: Eligible participants were 30 inpatients with schizophrenia according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision criteria. Patients were randomly allocated into two equal groups; one group of patients received risperidone 6 mg/day plus capsules of Zn sulfate (each containing 50 mg elemental Zn) three times a day and another group received risperidone 6 mg/day plus placebo. The Positive and Negative Syndrome Scale (PANSS) was applied to assess the psychotic symptoms and aggression risk at baseline, week 2, 4, and 6 of the study.

Results: The results of this study showed that both protocols significantly decreased the scores on all subscales of the PANSS and supplemental aggression risk subscale as well as PANSS total score over the study. However, this improvement was significantly higher in Zn sulfate receiving group compared to the placebo group. No major clinical side-effects were detected.

Conclusions: It may be concluded that Zn is an effective adjuvant agent in the management of patients with schizophrenia.

No MeSH data available.


Related in: MedlinePlus