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Antidepressant Effect of Combined Ketamine and Electroconvulsive Therapy on Patients With Major Depressive Disorder: A Randomized Trial.

Shams Alizadeh N, Maroufi A, Nasseri K, Sadeghi Najafabadi SH, Mousavi Taghiabad A, Gharibi F, Esfandiari GR - Iran J Psychiatry Behav Sci (2015)

Bottom Line: One of the shortcomings of the available treatments for major depressive disorder (MDD) is the time delay between starting the treatment and achieving an antidepressant response.However, the cognitive performance recovery time in the Ketamine group was lower than that in the control group (P = 0.042).Nevertheless, Ketamine may provide a better cognitive performance in patients under ECT.

View Article: PubMed Central - PubMed

Affiliation: Kurdistan Research Center for Social Determinants of Health, Department of Psychiatry, Qods Hospital, Kurdistan University of Medical Sciences, Sanandaj, IR Iran.

ABSTRACT

Background: One of the shortcomings of the available treatments for major depressive disorder (MDD) is the time delay between starting the treatment and achieving an antidepressant response.

Objectives: We aimed to determine the effect of Ketamine as a synergistic antidepressant and anesthetic agent on MDD in electroconvulsive therapy (ECT).

Patients and methods: Twenty-two patients with MDD received Ketamine and Propofol as anesthetic agents compared with 20 patients as the control group who received Propofol in a double-blind randomized clinical trial. The Hamilton rating scale for depression was used to determine the changes in symptoms severity during ECT and a 2-week follow-up.

Results: Both groups showed a reduction in depression severity, but there was no significant difference between the groups in the recovery process (P = 0.92). However, the cognitive performance recovery time in the Ketamine group was lower than that in the control group (P = 0.042).

Conclusions: This study could not show the effect of Ketamine on depression recovery in a 2-week follow-up period. Nevertheless, Ketamine may provide a better cognitive performance in patients under ECT.

No MeSH data available.


Related in: MedlinePlus

Comparison of the Mean Hamilton Score Variation Between the Ketamine and Control Groups During the TreatmentT1, one day before ECT onset; T2, A day after the third session; T3, A day after the last session; T4, Two weeks after the last session.
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A1578FIG3: Comparison of the Mean Hamilton Score Variation Between the Ketamine and Control Groups During the TreatmentT1, one day before ECT onset; T2, A day after the third session; T3, A day after the last session; T4, Two weeks after the last session.

Mentions: A comparison of the HRSD scores showed similar changes between the groups. There were no significant differences between the groups in terms of the rate and speed of the recovery process (P = 0.82, df = 3, F = 0.31) (Figure 3, Table 2).


Antidepressant Effect of Combined Ketamine and Electroconvulsive Therapy on Patients With Major Depressive Disorder: A Randomized Trial.

Shams Alizadeh N, Maroufi A, Nasseri K, Sadeghi Najafabadi SH, Mousavi Taghiabad A, Gharibi F, Esfandiari GR - Iran J Psychiatry Behav Sci (2015)

Comparison of the Mean Hamilton Score Variation Between the Ketamine and Control Groups During the TreatmentT1, one day before ECT onset; T2, A day after the third session; T3, A day after the last session; T4, Two weeks after the last session.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4644613&req=5

A1578FIG3: Comparison of the Mean Hamilton Score Variation Between the Ketamine and Control Groups During the TreatmentT1, one day before ECT onset; T2, A day after the third session; T3, A day after the last session; T4, Two weeks after the last session.
Mentions: A comparison of the HRSD scores showed similar changes between the groups. There were no significant differences between the groups in terms of the rate and speed of the recovery process (P = 0.82, df = 3, F = 0.31) (Figure 3, Table 2).

Bottom Line: One of the shortcomings of the available treatments for major depressive disorder (MDD) is the time delay between starting the treatment and achieving an antidepressant response.However, the cognitive performance recovery time in the Ketamine group was lower than that in the control group (P = 0.042).Nevertheless, Ketamine may provide a better cognitive performance in patients under ECT.

View Article: PubMed Central - PubMed

Affiliation: Kurdistan Research Center for Social Determinants of Health, Department of Psychiatry, Qods Hospital, Kurdistan University of Medical Sciences, Sanandaj, IR Iran.

ABSTRACT

Background: One of the shortcomings of the available treatments for major depressive disorder (MDD) is the time delay between starting the treatment and achieving an antidepressant response.

Objectives: We aimed to determine the effect of Ketamine as a synergistic antidepressant and anesthetic agent on MDD in electroconvulsive therapy (ECT).

Patients and methods: Twenty-two patients with MDD received Ketamine and Propofol as anesthetic agents compared with 20 patients as the control group who received Propofol in a double-blind randomized clinical trial. The Hamilton rating scale for depression was used to determine the changes in symptoms severity during ECT and a 2-week follow-up.

Results: Both groups showed a reduction in depression severity, but there was no significant difference between the groups in the recovery process (P = 0.92). However, the cognitive performance recovery time in the Ketamine group was lower than that in the control group (P = 0.042).

Conclusions: This study could not show the effect of Ketamine on depression recovery in a 2-week follow-up period. Nevertheless, Ketamine may provide a better cognitive performance in patients under ECT.

No MeSH data available.


Related in: MedlinePlus