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Bone Reconstruction following Application of Bone Matrix Gelatin to Alveolar Defects: A Randomized Clinical Trial.

Bayat M, Momen Heravi F, Mahmoudi M, Bahrami N - Int J Organ Transplant Med (2015)

Bottom Line: Qualitative histological and quantitative histometric analysis, including the percentage of new-formed bone fill and density were done.Assessment of the alveolar bone indicated that patients treated with BMG had significantly (p<0.05) better bone quality and quantity compared to the controls.In addition, bone density and histology revealed no differences between the newly induced and native bone.

View Article: PubMed Central - PubMed

Affiliation: Oral and Maxillofacial Surgery Department, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. Craniomaxillofacial Research Center, Tehran University of Medical Sciences, Tehran, Iran.

ABSTRACT

Background: Conventional dentoalveolar osseous reconstruction often involves the use of graft materials with or without barrier membranes.

Objective: To evaluate the efficacy of bone induction by bone matrix gelatin (BMG), delivered on an absorbable collagen sponge (ACS), compared to a placebo (ACS alone) in human alveolar socket defects.

Methods: 20 alveolar sockets from 10 healthy adults were studied. In all cases, both the mandibular premolar area and the contralateral premolar area (as the control site) were involved. In each of the 10 patients, the extraction sites were filled randomly with BMG and ACS. The repair response was examined on day 90. Qualitative histological and quantitative histometric analysis, including the percentage of new-formed bone fill and density were done.

Results: Assessment of the alveolar bone indicated that patients treated with BMG had significantly (p<0.05) better bone quality and quantity compared to the controls. In addition, bone density and histology revealed no differences between the newly induced and native bone.

Conclusion: The data from this single-blind clinical trial demonstrated that the novel combination of BMG had a striking effect on de novo osseous formation for the bone regeneration.

No MeSH data available.


Day 90; a) bone matrix gelatin, b) absorbable collagen sponge
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Figure 1: Day 90; a) bone matrix gelatin, b) absorbable collagen sponge

Mentions: In the site of BMG, active remodeling of the surgical cavity was detectable in samples from the ACS sites, with normal lamellar bone structure, trabecular spaces and hematopoietic tissue. Active remodeling of the surgical cavity was detectable in samples from the BMG site, with normal cortical bone structure, bone trabeculae, and hematopoietic tissue. Newly formed bone showed recovery with normal characteristic. At the level of the medullary channel, no apparent alterations existed when the resident and healed bones were compared. From all aspects, the freshly formed bone in the BMG sites, exhibited qualities similar to that of the local bone or showed fairly dense trabeculation (Fig 1).


Bone Reconstruction following Application of Bone Matrix Gelatin to Alveolar Defects: A Randomized Clinical Trial.

Bayat M, Momen Heravi F, Mahmoudi M, Bahrami N - Int J Organ Transplant Med (2015)

Day 90; a) bone matrix gelatin, b) absorbable collagen sponge
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4644570&req=5

Figure 1: Day 90; a) bone matrix gelatin, b) absorbable collagen sponge
Mentions: In the site of BMG, active remodeling of the surgical cavity was detectable in samples from the ACS sites, with normal lamellar bone structure, trabecular spaces and hematopoietic tissue. Active remodeling of the surgical cavity was detectable in samples from the BMG site, with normal cortical bone structure, bone trabeculae, and hematopoietic tissue. Newly formed bone showed recovery with normal characteristic. At the level of the medullary channel, no apparent alterations existed when the resident and healed bones were compared. From all aspects, the freshly formed bone in the BMG sites, exhibited qualities similar to that of the local bone or showed fairly dense trabeculation (Fig 1).

Bottom Line: Qualitative histological and quantitative histometric analysis, including the percentage of new-formed bone fill and density were done.Assessment of the alveolar bone indicated that patients treated with BMG had significantly (p<0.05) better bone quality and quantity compared to the controls.In addition, bone density and histology revealed no differences between the newly induced and native bone.

View Article: PubMed Central - PubMed

Affiliation: Oral and Maxillofacial Surgery Department, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. Craniomaxillofacial Research Center, Tehran University of Medical Sciences, Tehran, Iran.

ABSTRACT

Background: Conventional dentoalveolar osseous reconstruction often involves the use of graft materials with or without barrier membranes.

Objective: To evaluate the efficacy of bone induction by bone matrix gelatin (BMG), delivered on an absorbable collagen sponge (ACS), compared to a placebo (ACS alone) in human alveolar socket defects.

Methods: 20 alveolar sockets from 10 healthy adults were studied. In all cases, both the mandibular premolar area and the contralateral premolar area (as the control site) were involved. In each of the 10 patients, the extraction sites were filled randomly with BMG and ACS. The repair response was examined on day 90. Qualitative histological and quantitative histometric analysis, including the percentage of new-formed bone fill and density were done.

Results: Assessment of the alveolar bone indicated that patients treated with BMG had significantly (p<0.05) better bone quality and quantity compared to the controls. In addition, bone density and histology revealed no differences between the newly induced and native bone.

Conclusion: The data from this single-blind clinical trial demonstrated that the novel combination of BMG had a striking effect on de novo osseous formation for the bone regeneration.

No MeSH data available.