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MR Prediction of Liver Function and Pathology Using Gd-EOB-DTPA: Effect of Liver Volume Consideration.

Shimamoto D, Nishie A, Asayama Y, Ushijima Y, Takayama Y, Fujita N, Shirabe K, Hida T, Kubo Y, Honda H - Biomed Res Int (2015)

Bottom Line: The correlation coefficients were compared between ΔLSR (ΔLMR) and ΔLSR (ΔLMR) × LV.The correlation coefficient between ΔLSR (ΔLMR) × LV and cholinesterase was significantly higher than that between ΔLSR (ΔLMR) and cholinesterase.The inclusion of liver volume may improve Gd-EOB-DTPA-based predictions of liver function, but not in predictions of liver pathology.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

ABSTRACT

Purpose: To evaluate whether the diagnostic performance of Gd-EOB-DTPA-enhanced MRI in evaluating liver function and pathology is improved by considering liver volume (LV).

Methods: This retrospective study included 104 patients who underwent Gd-EOB-DTPA-enhanced MRI before liver surgery. For each patient, using the precontrast and hepatobiliary phase images, we calculated the increase rate of the liver-to-spleen signal intensity ratio (LSR), that is, the "ΔLSR," and the increase rate of the liver-to-muscle signal intensity ratio (LMR), that is, the "ΔLMR." ΔLSR × LV and ΔLMR × LV were also calculated. The correlation of each MR parameter with liver function data or liver pathology was assessed. The correlation coefficients were compared between ΔLSR (ΔLMR) and ΔLSR (ΔLMR) × LV.

Results: The correlation coefficient between ΔLSR (ΔLMR) × LV and cholinesterase was significantly higher than that between ΔLSR (ΔLMR) and cholinesterase. The correlation coefficient between ΔLSR (ΔLMR) × LV and the degree of fibrosis or necroinflammatory activity was significantly lower than that between ΔLSR (ΔLMR) and the degree of fibrosis or necroinflammatory activity.

Conclusion: The inclusion of liver volume may improve Gd-EOB-DTPA-based predictions of liver function, but not in predictions of liver pathology.

No MeSH data available.


Related in: MedlinePlus

Hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI. The signal intensities were measured by placing the largest possible regions of interest (ROIs) on the liver parenchyma, spleen, and erector spinae muscle, avoiding vessels, tumors, and artifacts. For the liver parenchyma, two round or oval ROIs were placed: one in the right lobe and the other in the left.
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fig1: Hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI. The signal intensities were measured by placing the largest possible regions of interest (ROIs) on the liver parenchyma, spleen, and erector spinae muscle, avoiding vessels, tumors, and artifacts. For the liver parenchyma, two round or oval ROIs were placed: one in the right lobe and the other in the left.

Mentions: The signal intensity of axial eTHRIVE on Gd-EOB-DTPA-enhanced MRI was measured on the same DICOM viewer. First, two abdominal radiologists with six and 19 years of experience together selected three slices without significant artifacts. On the same slices they measured the signal intensities by placing the largest possible region of interest (ROI) on the liver parenchyma, spleen, and erector spinae muscle, avoiding vessels, tumors, and artifacts in a consensus manner (Figure 1). For the liver parenchyma, two round or oval ROIs were placed: one in the right lobe and the other in the left. The averages of the six signal intensities of the liver parenchyma and the three signal intensities of the spleen or the erector spinae muscle were calculated.


MR Prediction of Liver Function and Pathology Using Gd-EOB-DTPA: Effect of Liver Volume Consideration.

Shimamoto D, Nishie A, Asayama Y, Ushijima Y, Takayama Y, Fujita N, Shirabe K, Hida T, Kubo Y, Honda H - Biomed Res Int (2015)

Hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI. The signal intensities were measured by placing the largest possible regions of interest (ROIs) on the liver parenchyma, spleen, and erector spinae muscle, avoiding vessels, tumors, and artifacts. For the liver parenchyma, two round or oval ROIs were placed: one in the right lobe and the other in the left.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4644534&req=5

fig1: Hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI. The signal intensities were measured by placing the largest possible regions of interest (ROIs) on the liver parenchyma, spleen, and erector spinae muscle, avoiding vessels, tumors, and artifacts. For the liver parenchyma, two round or oval ROIs were placed: one in the right lobe and the other in the left.
Mentions: The signal intensity of axial eTHRIVE on Gd-EOB-DTPA-enhanced MRI was measured on the same DICOM viewer. First, two abdominal radiologists with six and 19 years of experience together selected three slices without significant artifacts. On the same slices they measured the signal intensities by placing the largest possible region of interest (ROI) on the liver parenchyma, spleen, and erector spinae muscle, avoiding vessels, tumors, and artifacts in a consensus manner (Figure 1). For the liver parenchyma, two round or oval ROIs were placed: one in the right lobe and the other in the left. The averages of the six signal intensities of the liver parenchyma and the three signal intensities of the spleen or the erector spinae muscle were calculated.

Bottom Line: The correlation coefficients were compared between ΔLSR (ΔLMR) and ΔLSR (ΔLMR) × LV.The correlation coefficient between ΔLSR (ΔLMR) × LV and cholinesterase was significantly higher than that between ΔLSR (ΔLMR) and cholinesterase.The inclusion of liver volume may improve Gd-EOB-DTPA-based predictions of liver function, but not in predictions of liver pathology.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

ABSTRACT

Purpose: To evaluate whether the diagnostic performance of Gd-EOB-DTPA-enhanced MRI in evaluating liver function and pathology is improved by considering liver volume (LV).

Methods: This retrospective study included 104 patients who underwent Gd-EOB-DTPA-enhanced MRI before liver surgery. For each patient, using the precontrast and hepatobiliary phase images, we calculated the increase rate of the liver-to-spleen signal intensity ratio (LSR), that is, the "ΔLSR," and the increase rate of the liver-to-muscle signal intensity ratio (LMR), that is, the "ΔLMR." ΔLSR × LV and ΔLMR × LV were also calculated. The correlation of each MR parameter with liver function data or liver pathology was assessed. The correlation coefficients were compared between ΔLSR (ΔLMR) and ΔLSR (ΔLMR) × LV.

Results: The correlation coefficient between ΔLSR (ΔLMR) × LV and cholinesterase was significantly higher than that between ΔLSR (ΔLMR) and cholinesterase. The correlation coefficient between ΔLSR (ΔLMR) × LV and the degree of fibrosis or necroinflammatory activity was significantly lower than that between ΔLSR (ΔLMR) and the degree of fibrosis or necroinflammatory activity.

Conclusion: The inclusion of liver volume may improve Gd-EOB-DTPA-based predictions of liver function, but not in predictions of liver pathology.

No MeSH data available.


Related in: MedlinePlus