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Evaluation of Prognostic Values of Tissue Plasminogen Activator and Plasminogen Activator Inhibitor-1 in Crimean-Congo Hemorrhagic Fever Patients.

Gurbuz Y, Ozturk B, Tutuncu EE, Sencan I, Cicek Senturk G, Altay FA - Jundishapur J Microbiol (2015)

Bottom Line: A total of 46 patients participated in this study.The significant differences between recovering patients and the patients who died, regarding Aspartate aminotransferase (AST), Creatine Phosphokinase (CPK), Lactate Dehydrogenase (LDH), Prothrombin Time (PT), activated Partial Thromboplastin time (aPTT), and thrombocyte and fibrinogen levels, were consistent with many clinical studies in the literature.The fatal cases were found to have higher tPA and PAI-1 levels in contrast to the patients who completely recovered.

View Article: PubMed Central - PubMed

Affiliation: Infectious Diseases and Clinical Microbiology Clinics, Diskapi Yildirim Beyazit Training and Research Hospital, Ministry of Health, Ankara, Turkey.

ABSTRACT

Background: Crimean-Congo hemorrhagic fever (CCHF) is a widespread disease in Turkey, and was responsible for many deaths in endemic regions during the last decade. The pathogenesis of the disease is not fully understood yet.

Objectives: In this study we aimed to determine the levels of tissue plasminogen activator (tPA) and Plasminogen activator inhibitor-1 (PAI-1) as predictors of prognosis in CCHF.

Patients and methods: Patients who were diagnosed by the polymerase chain reaction (PCR) and IgM positivity in the reference laboratory were included in this study. Tissue Plasminogen activator and PAI-1 levels were measured by the enzyme linked immunosorbent assay (ELISA) using a commercial kit (human t-PA ELISA and human PAL-1 ELISA; BioVendor research and diagnostic products, BioVendor-Laboratorni medicina a.s., Brno, Czech Republic).

Results: A total of 46 patients participated in this study. The significant differences between recovering patients and the patients who died, regarding Aspartate aminotransferase (AST), Creatine Phosphokinase (CPK), Lactate Dehydrogenase (LDH), Prothrombin Time (PT), activated Partial Thromboplastin time (aPTT), and thrombocyte and fibrinogen levels, were consistent with many clinical studies in the literature. The fatal cases were found to have higher tPA and PAI-1 levels in contrast to the patients who completely recovered.

Conclusions: We think that these findings may help the progress of understanding of CCHF pathogenesis.

No MeSH data available.


Related in: MedlinePlus

The Correlation Between Plasminogen Activator Inhibitor-1 Levels and Bleeding Scores (PT And Aptt) in Crimean-Congo Hemorrhagic Fever Patients
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fig24183: The Correlation Between Plasminogen Activator Inhibitor-1 Levels and Bleeding Scores (PT And Aptt) in Crimean-Congo Hemorrhagic Fever Patients

Mentions: The tPA and PAI-1 levels were significantly higher in fatal cases than patients who recovered (Table 1). The PAI-1 levels exhibited a positive correlation with PT and aPTT values (PT: r = 500, P < 0.001, aPTT: r = 724, P < 0.001) (Figure 1).


Evaluation of Prognostic Values of Tissue Plasminogen Activator and Plasminogen Activator Inhibitor-1 in Crimean-Congo Hemorrhagic Fever Patients.

Gurbuz Y, Ozturk B, Tutuncu EE, Sencan I, Cicek Senturk G, Altay FA - Jundishapur J Microbiol (2015)

The Correlation Between Plasminogen Activator Inhibitor-1 Levels and Bleeding Scores (PT And Aptt) in Crimean-Congo Hemorrhagic Fever Patients
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4644349&req=5

fig24183: The Correlation Between Plasminogen Activator Inhibitor-1 Levels and Bleeding Scores (PT And Aptt) in Crimean-Congo Hemorrhagic Fever Patients
Mentions: The tPA and PAI-1 levels were significantly higher in fatal cases than patients who recovered (Table 1). The PAI-1 levels exhibited a positive correlation with PT and aPTT values (PT: r = 500, P < 0.001, aPTT: r = 724, P < 0.001) (Figure 1).

Bottom Line: A total of 46 patients participated in this study.The significant differences between recovering patients and the patients who died, regarding Aspartate aminotransferase (AST), Creatine Phosphokinase (CPK), Lactate Dehydrogenase (LDH), Prothrombin Time (PT), activated Partial Thromboplastin time (aPTT), and thrombocyte and fibrinogen levels, were consistent with many clinical studies in the literature.The fatal cases were found to have higher tPA and PAI-1 levels in contrast to the patients who completely recovered.

View Article: PubMed Central - PubMed

Affiliation: Infectious Diseases and Clinical Microbiology Clinics, Diskapi Yildirim Beyazit Training and Research Hospital, Ministry of Health, Ankara, Turkey.

ABSTRACT

Background: Crimean-Congo hemorrhagic fever (CCHF) is a widespread disease in Turkey, and was responsible for many deaths in endemic regions during the last decade. The pathogenesis of the disease is not fully understood yet.

Objectives: In this study we aimed to determine the levels of tissue plasminogen activator (tPA) and Plasminogen activator inhibitor-1 (PAI-1) as predictors of prognosis in CCHF.

Patients and methods: Patients who were diagnosed by the polymerase chain reaction (PCR) and IgM positivity in the reference laboratory were included in this study. Tissue Plasminogen activator and PAI-1 levels were measured by the enzyme linked immunosorbent assay (ELISA) using a commercial kit (human t-PA ELISA and human PAL-1 ELISA; BioVendor research and diagnostic products, BioVendor-Laboratorni medicina a.s., Brno, Czech Republic).

Results: A total of 46 patients participated in this study. The significant differences between recovering patients and the patients who died, regarding Aspartate aminotransferase (AST), Creatine Phosphokinase (CPK), Lactate Dehydrogenase (LDH), Prothrombin Time (PT), activated Partial Thromboplastin time (aPTT), and thrombocyte and fibrinogen levels, were consistent with many clinical studies in the literature. The fatal cases were found to have higher tPA and PAI-1 levels in contrast to the patients who completely recovered.

Conclusions: We think that these findings may help the progress of understanding of CCHF pathogenesis.

No MeSH data available.


Related in: MedlinePlus