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Peanut sensitization pattern in Norwegian children and adults with specific IgE to peanut show age related differences.

Namork E, Stensby BA - Allergy Asthma Clin Immunol (2015)

Bottom Line: Serum samples negative to the above allergens were analyzed for sIgE to Ara h 6, and sIgE to Pru p 3 in peach were analyzed in sera positive to the cross-reactive allergen Ara h 9.Highest frequency of sIgE to Ara h 2, often co-sensitized to Ara h 1 and 3, were found in the small children up to 6 years of age.The sIgE levels to the storage proteins Ara h 1, 2 and 3 were strongly correlated, as was the sIgE levels to Ara h 8 and birch pollen extract.

View Article: PubMed Central - PubMed

Affiliation: Division of Environmental Medicine, Department of Food, Water and Cosmetics, Norwegian Institute of Public Health, PO Box 4404, 0403 Oslo, Norway ; Lovisenberggata 8, Oslo, Norway.

ABSTRACT

Background: Peanuts contain potent food allergens and the prevalence of allergy is reported to increase, especially in children. Since peanut sensitization may differ between different geographical regions, we wanted to investigate the sensitization pattern to the individual peanut allergens in a Norwegian population.

Methods: Cases reported to the Norwegian Food Allergy Register with sera positive to peanut extract were analyzed for specific IgE (sIgE) to the recombinant peanut allergens Ara h 1, Ara h 2, Ara h 3, Ara h 8 and Ara h 9 and to birch pollen extract. Serum samples negative to the above allergens were analyzed for sIgE to Ara h 6, and sIgE to Pru p 3 in peach were analyzed in sera positive to the cross-reactive allergen Ara h 9.

Results: Highest frequency of sIgE to Ara h 2, often co-sensitized to Ara h 1 and 3, were found in the small children up to 6 years of age. From the age of 6 years, sensitization to Ara h 8 was predominant. The sIgE levels to the storage proteins Ara h 1, 2 and 3 were strongly correlated, as was the sIgE levels to Ara h 8 and birch pollen extract. A low sensitization rate of sIgE to Ara h 9 in young adults was observed, which sIgE levels were very strongly correlated to Pru p 3.

Conclusion: The sensitization to peanut allergens in a Norwegian population shows a clear age dependent pattern. The results add to the previously published research on the sensitization patterns of peanut sensitized patients in different geographical areas.

No MeSH data available.


Related in: MedlinePlus

Sensitization pattern of specific IgE-antibodies to the peanut allergens and birch pollen extract in the four age groups showing highest frequency of sensitization to Ara h 2 in the youngest age groups, and highest frequency of sensitization to Ara h8 from the age of 6 years and in the older age groups
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Fig2: Sensitization pattern of specific IgE-antibodies to the peanut allergens and birch pollen extract in the four age groups showing highest frequency of sensitization to Ara h 2 in the youngest age groups, and highest frequency of sensitization to Ara h8 from the age of 6 years and in the older age groups

Mentions: Specific IgE sensitization to the individual peanut allergens differed between the four age groups. Sensitization to the major storage proteins was highest in the youngest age groups and lowest in the oldest age group. The decrease according to age was especially marked with respect to Ara h 2 (Fig. 2). The youngest children (0–5 years) were most frequently sensitized to the seed storage protein Ara h 2 (58.0 %), but were frequently co-sensitized to Ara h 1 (44 %) and Ara h 3 (27 %) in different combinations. The four sera with sIgE to Ara h 6 were all from patients in the small children’s group. Sensitization to the lipid transfer protein Ara h 9 was seen in all age groups (only one positive in the children’s group) but most frequently among the young adults (26–45 years) (Fig. 2). The birch pollen homologue Ara h 8 increased markedly in frequency from 23.3 % in the youngest children to 56.3 % at the age of 6 years and was found to be 68.2 % in oldest age group. Similarly, sensitization to birch pollen showed a marked increase in frequency of sensitization from 41.9 % in the youngest children to 83.3 % at the age of 6 and showed similar high frequencies in the two older age groups (86.4 %) (Fig. 2). A level of sIgE to Ara h 2 > 2.0 kU/l, considered to be diagnostic for clinical peanut allergy [19], was found in 51.2 % of the sera from patients in the youngest age group. Sera with levels above this value decreased with age to 31.3 % in the second age group, 15 % in the third age group to none in the oldest age group (Table 1).Fig. 2


Peanut sensitization pattern in Norwegian children and adults with specific IgE to peanut show age related differences.

Namork E, Stensby BA - Allergy Asthma Clin Immunol (2015)

Sensitization pattern of specific IgE-antibodies to the peanut allergens and birch pollen extract in the four age groups showing highest frequency of sensitization to Ara h 2 in the youngest age groups, and highest frequency of sensitization to Ara h8 from the age of 6 years and in the older age groups
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4644336&req=5

Fig2: Sensitization pattern of specific IgE-antibodies to the peanut allergens and birch pollen extract in the four age groups showing highest frequency of sensitization to Ara h 2 in the youngest age groups, and highest frequency of sensitization to Ara h8 from the age of 6 years and in the older age groups
Mentions: Specific IgE sensitization to the individual peanut allergens differed between the four age groups. Sensitization to the major storage proteins was highest in the youngest age groups and lowest in the oldest age group. The decrease according to age was especially marked with respect to Ara h 2 (Fig. 2). The youngest children (0–5 years) were most frequently sensitized to the seed storage protein Ara h 2 (58.0 %), but were frequently co-sensitized to Ara h 1 (44 %) and Ara h 3 (27 %) in different combinations. The four sera with sIgE to Ara h 6 were all from patients in the small children’s group. Sensitization to the lipid transfer protein Ara h 9 was seen in all age groups (only one positive in the children’s group) but most frequently among the young adults (26–45 years) (Fig. 2). The birch pollen homologue Ara h 8 increased markedly in frequency from 23.3 % in the youngest children to 56.3 % at the age of 6 years and was found to be 68.2 % in oldest age group. Similarly, sensitization to birch pollen showed a marked increase in frequency of sensitization from 41.9 % in the youngest children to 83.3 % at the age of 6 and showed similar high frequencies in the two older age groups (86.4 %) (Fig. 2). A level of sIgE to Ara h 2 > 2.0 kU/l, considered to be diagnostic for clinical peanut allergy [19], was found in 51.2 % of the sera from patients in the youngest age group. Sera with levels above this value decreased with age to 31.3 % in the second age group, 15 % in the third age group to none in the oldest age group (Table 1).Fig. 2

Bottom Line: Serum samples negative to the above allergens were analyzed for sIgE to Ara h 6, and sIgE to Pru p 3 in peach were analyzed in sera positive to the cross-reactive allergen Ara h 9.Highest frequency of sIgE to Ara h 2, often co-sensitized to Ara h 1 and 3, were found in the small children up to 6 years of age.The sIgE levels to the storage proteins Ara h 1, 2 and 3 were strongly correlated, as was the sIgE levels to Ara h 8 and birch pollen extract.

View Article: PubMed Central - PubMed

Affiliation: Division of Environmental Medicine, Department of Food, Water and Cosmetics, Norwegian Institute of Public Health, PO Box 4404, 0403 Oslo, Norway ; Lovisenberggata 8, Oslo, Norway.

ABSTRACT

Background: Peanuts contain potent food allergens and the prevalence of allergy is reported to increase, especially in children. Since peanut sensitization may differ between different geographical regions, we wanted to investigate the sensitization pattern to the individual peanut allergens in a Norwegian population.

Methods: Cases reported to the Norwegian Food Allergy Register with sera positive to peanut extract were analyzed for specific IgE (sIgE) to the recombinant peanut allergens Ara h 1, Ara h 2, Ara h 3, Ara h 8 and Ara h 9 and to birch pollen extract. Serum samples negative to the above allergens were analyzed for sIgE to Ara h 6, and sIgE to Pru p 3 in peach were analyzed in sera positive to the cross-reactive allergen Ara h 9.

Results: Highest frequency of sIgE to Ara h 2, often co-sensitized to Ara h 1 and 3, were found in the small children up to 6 years of age. From the age of 6 years, sensitization to Ara h 8 was predominant. The sIgE levels to the storage proteins Ara h 1, 2 and 3 were strongly correlated, as was the sIgE levels to Ara h 8 and birch pollen extract. A low sensitization rate of sIgE to Ara h 9 in young adults was observed, which sIgE levels were very strongly correlated to Pru p 3.

Conclusion: The sensitization to peanut allergens in a Norwegian population shows a clear age dependent pattern. The results add to the previously published research on the sensitization patterns of peanut sensitized patients in different geographical areas.

No MeSH data available.


Related in: MedlinePlus