Limits...
Absorption Kinetics of Subcutaneously Administered Ceftazidime in Hypoperfused Guinea Pigs.

Ebihara T, Oshima S, Okita M, Shiina S, Negishi A, Ohara K, Ohshima S, Iwasaki H, Yoneyama A, Kitazumi E, Kobayashi D - Curr Ther Res Clin Exp (2014)

Bottom Line: Application of MWCs or WCs after subcutaneous CAZ injection led to higher CAZ plasma levels than the mutant prevention concentration for a longer period than was observed for CAZ administration without the application of MWCs or WCs.The application of MWCs or WCs enhanced subcutaneous CAZ absorption by increasing blood flow.MWCs and WCs are considered to be safe and routine methods to induce defecation after surgery on the digestive system; thus, the combination of these methods and subcutaneous CAZ administration is a potential method for treating pneumonia in patients with SMID.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacy Services, National Rehabilitation Center for Children with Disabilities, Tokyo, Japan.

ABSTRACT

Background: Pneumonia is the most common cause of death in patients with severe motor and intellectual disabilities (SMID), and intravenous ceftazidime (CAZ) is a widely used treatment for such infections. However, intravenous administration in patients with SMID may be difficult because of insufficient vascular development.

Objectives: The aim of our study was to determine the feasibility of subcutaneous drug administration by mentholated warm compresses (WMCs) as an alternative delivery method for ceftazidime in patients with SMID.

Methods: CAZ was subcutaneously administered to the abdominal region of naphazoline-treated hypoperfused guinea pigs, which were used as a hemodynamic model of patients with SMID. MWCs or warm compresses (WCs) were applied to the injection site to increase blood flow. We calculated the cumulative CAZ absorption over time by using the deconvolution method.

Results: Application of MWCs or WCs increased blood flow at the administration site and increased CAZ plasma levels. Application of MWCs or WCs after subcutaneous CAZ injection led to higher CAZ plasma levels than the mutant prevention concentration for a longer period than was observed for CAZ administration without the application of MWCs or WCs.

Conclusions: The application of MWCs or WCs enhanced subcutaneous CAZ absorption by increasing blood flow. MWCs and WCs are considered to be safe and routine methods to induce defecation after surgery on the digestive system; thus, the combination of these methods and subcutaneous CAZ administration is a potential method for treating pneumonia in patients with SMID.

No MeSH data available.


Related in: MedlinePlus

Effects of mentholated warm compresses (MWCs) and warm compresses (WCs) on cefazidime (CAZ) subcutaneous absorption in hypoperfused guinea pigs. CAZ was administered subcutaneously at a dose of 17 mg (1D) over a 30-minute time period (1D1V). (A) CAZ plasma concentration-time curves. (B) Blood flow changes. (C) Cumulative amounts of absorbed CAZ as obtained by the deconvolution method. Each point represents the mean (SD) (n = 3). *P < 0.05 (+WC vs 1D1V). #P < 0.05 (+MWC vs 1D1V).
© Copyright Policy - CC BY-NC-SA
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4644240&req=5

f0020: Effects of mentholated warm compresses (MWCs) and warm compresses (WCs) on cefazidime (CAZ) subcutaneous absorption in hypoperfused guinea pigs. CAZ was administered subcutaneously at a dose of 17 mg (1D) over a 30-minute time period (1D1V). (A) CAZ plasma concentration-time curves. (B) Blood flow changes. (C) Cumulative amounts of absorbed CAZ as obtained by the deconvolution method. Each point represents the mean (SD) (n = 3). *P < 0.05 (+WC vs 1D1V). #P < 0.05 (+MWC vs 1D1V).

Mentions: MWCs and WCs were applied to the 1D1V group. CAZ plasma levels were markedly increased in both the MWC and WC groups compared with the control group, and were approximately 4 and 6 times higher, respectively, than in the control group 6 hours after administration (Figure 4A). Naphazoline administration resulted in a blood flow decrease, which was partially inhibited by the application of an MWC or a WC (Figure 4B). Figure 4C shows the cumulative CAZ absorption as estimated using the deconvolution method. CAZ absorption after subcutaneous administration was about 84.0% complete in the MWC group (14.1 mg absorbed) after 6 hours, whereas 60.0% of the administered CAZ was absorbed in the WC group. The average absorption rate throughout the period of experimentation was increased compared with the 1D1V group by the application of WCs or MWCs (1D1V, 0.013 mg/min; with WC, 0.027 mg/min; with MWC, 0.039 mg/min). The increased absorption that was produced by application of an MWC or WC reached levels equivalent to those of the 1D2V and 2D1V groups (Figure 3C).


Absorption Kinetics of Subcutaneously Administered Ceftazidime in Hypoperfused Guinea Pigs.

Ebihara T, Oshima S, Okita M, Shiina S, Negishi A, Ohara K, Ohshima S, Iwasaki H, Yoneyama A, Kitazumi E, Kobayashi D - Curr Ther Res Clin Exp (2014)

Effects of mentholated warm compresses (MWCs) and warm compresses (WCs) on cefazidime (CAZ) subcutaneous absorption in hypoperfused guinea pigs. CAZ was administered subcutaneously at a dose of 17 mg (1D) over a 30-minute time period (1D1V). (A) CAZ plasma concentration-time curves. (B) Blood flow changes. (C) Cumulative amounts of absorbed CAZ as obtained by the deconvolution method. Each point represents the mean (SD) (n = 3). *P < 0.05 (+WC vs 1D1V). #P < 0.05 (+MWC vs 1D1V).
© Copyright Policy - CC BY-NC-SA
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4644240&req=5

f0020: Effects of mentholated warm compresses (MWCs) and warm compresses (WCs) on cefazidime (CAZ) subcutaneous absorption in hypoperfused guinea pigs. CAZ was administered subcutaneously at a dose of 17 mg (1D) over a 30-minute time period (1D1V). (A) CAZ plasma concentration-time curves. (B) Blood flow changes. (C) Cumulative amounts of absorbed CAZ as obtained by the deconvolution method. Each point represents the mean (SD) (n = 3). *P < 0.05 (+WC vs 1D1V). #P < 0.05 (+MWC vs 1D1V).
Mentions: MWCs and WCs were applied to the 1D1V group. CAZ plasma levels were markedly increased in both the MWC and WC groups compared with the control group, and were approximately 4 and 6 times higher, respectively, than in the control group 6 hours after administration (Figure 4A). Naphazoline administration resulted in a blood flow decrease, which was partially inhibited by the application of an MWC or a WC (Figure 4B). Figure 4C shows the cumulative CAZ absorption as estimated using the deconvolution method. CAZ absorption after subcutaneous administration was about 84.0% complete in the MWC group (14.1 mg absorbed) after 6 hours, whereas 60.0% of the administered CAZ was absorbed in the WC group. The average absorption rate throughout the period of experimentation was increased compared with the 1D1V group by the application of WCs or MWCs (1D1V, 0.013 mg/min; with WC, 0.027 mg/min; with MWC, 0.039 mg/min). The increased absorption that was produced by application of an MWC or WC reached levels equivalent to those of the 1D2V and 2D1V groups (Figure 3C).

Bottom Line: Application of MWCs or WCs after subcutaneous CAZ injection led to higher CAZ plasma levels than the mutant prevention concentration for a longer period than was observed for CAZ administration without the application of MWCs or WCs.The application of MWCs or WCs enhanced subcutaneous CAZ absorption by increasing blood flow.MWCs and WCs are considered to be safe and routine methods to induce defecation after surgery on the digestive system; thus, the combination of these methods and subcutaneous CAZ administration is a potential method for treating pneumonia in patients with SMID.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacy Services, National Rehabilitation Center for Children with Disabilities, Tokyo, Japan.

ABSTRACT

Background: Pneumonia is the most common cause of death in patients with severe motor and intellectual disabilities (SMID), and intravenous ceftazidime (CAZ) is a widely used treatment for such infections. However, intravenous administration in patients with SMID may be difficult because of insufficient vascular development.

Objectives: The aim of our study was to determine the feasibility of subcutaneous drug administration by mentholated warm compresses (WMCs) as an alternative delivery method for ceftazidime in patients with SMID.

Methods: CAZ was subcutaneously administered to the abdominal region of naphazoline-treated hypoperfused guinea pigs, which were used as a hemodynamic model of patients with SMID. MWCs or warm compresses (WCs) were applied to the injection site to increase blood flow. We calculated the cumulative CAZ absorption over time by using the deconvolution method.

Results: Application of MWCs or WCs increased blood flow at the administration site and increased CAZ plasma levels. Application of MWCs or WCs after subcutaneous CAZ injection led to higher CAZ plasma levels than the mutant prevention concentration for a longer period than was observed for CAZ administration without the application of MWCs or WCs.

Conclusions: The application of MWCs or WCs enhanced subcutaneous CAZ absorption by increasing blood flow. MWCs and WCs are considered to be safe and routine methods to induce defecation after surgery on the digestive system; thus, the combination of these methods and subcutaneous CAZ administration is a potential method for treating pneumonia in patients with SMID.

No MeSH data available.


Related in: MedlinePlus