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Absorption Kinetics of Subcutaneously Administered Ceftazidime in Hypoperfused Guinea Pigs.

Ebihara T, Oshima S, Okita M, Shiina S, Negishi A, Ohara K, Ohshima S, Iwasaki H, Yoneyama A, Kitazumi E, Kobayashi D - Curr Ther Res Clin Exp (2014)

Bottom Line: Application of MWCs or WCs after subcutaneous CAZ injection led to higher CAZ plasma levels than the mutant prevention concentration for a longer period than was observed for CAZ administration without the application of MWCs or WCs.The application of MWCs or WCs enhanced subcutaneous CAZ absorption by increasing blood flow.MWCs and WCs are considered to be safe and routine methods to induce defecation after surgery on the digestive system; thus, the combination of these methods and subcutaneous CAZ administration is a potential method for treating pneumonia in patients with SMID.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacy Services, National Rehabilitation Center for Children with Disabilities, Tokyo, Japan.

ABSTRACT

Background: Pneumonia is the most common cause of death in patients with severe motor and intellectual disabilities (SMID), and intravenous ceftazidime (CAZ) is a widely used treatment for such infections. However, intravenous administration in patients with SMID may be difficult because of insufficient vascular development.

Objectives: The aim of our study was to determine the feasibility of subcutaneous drug administration by mentholated warm compresses (WMCs) as an alternative delivery method for ceftazidime in patients with SMID.

Methods: CAZ was subcutaneously administered to the abdominal region of naphazoline-treated hypoperfused guinea pigs, which were used as a hemodynamic model of patients with SMID. MWCs or warm compresses (WCs) were applied to the injection site to increase blood flow. We calculated the cumulative CAZ absorption over time by using the deconvolution method.

Results: Application of MWCs or WCs increased blood flow at the administration site and increased CAZ plasma levels. Application of MWCs or WCs after subcutaneous CAZ injection led to higher CAZ plasma levels than the mutant prevention concentration for a longer period than was observed for CAZ administration without the application of MWCs or WCs.

Conclusions: The application of MWCs or WCs enhanced subcutaneous CAZ absorption by increasing blood flow. MWCs and WCs are considered to be safe and routine methods to induce defecation after surgery on the digestive system; thus, the combination of these methods and subcutaneous CAZ administration is a potential method for treating pneumonia in patients with SMID.

No MeSH data available.


Related in: MedlinePlus

Blood flow changes in hypoperfused guinea pigs. Guinea pigs received an intramuscular injection of saline and either 0.15 mg/kg naphazoline or 1.5 mg/kg naphazoline as a vasoconstrictor, 150 minutes after anesthesia. Blood flow was measured every 10 minutes for 6 hours. Each point represents the mean (SD) (saline group, n = 8; 0.15 mg/kg naphazoline group, n = 4; 1.5 mg/kg naphazoline group, n = 4). *P < 0.05 (0.15 mg/kg vs. saline). #P < 0.05 (1.5 mg/kg vs saline).
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f0005: Blood flow changes in hypoperfused guinea pigs. Guinea pigs received an intramuscular injection of saline and either 0.15 mg/kg naphazoline or 1.5 mg/kg naphazoline as a vasoconstrictor, 150 minutes after anesthesia. Blood flow was measured every 10 minutes for 6 hours. Each point represents the mean (SD) (saline group, n = 8; 0.15 mg/kg naphazoline group, n = 4; 1.5 mg/kg naphazoline group, n = 4). *P < 0.05 (0.15 mg/kg vs. saline). #P < 0.05 (1.5 mg/kg vs saline).

Mentions: After administration of 0.15 and 1.5 mg/kg naphazoline, blood flow immediately decreased by 30% and 50%, respectively, compared with baseline. The reduction of blood flow caused by 1.5 mg/kg naphazoline administration persisted until the end of the measurement period (Figure 1).


Absorption Kinetics of Subcutaneously Administered Ceftazidime in Hypoperfused Guinea Pigs.

Ebihara T, Oshima S, Okita M, Shiina S, Negishi A, Ohara K, Ohshima S, Iwasaki H, Yoneyama A, Kitazumi E, Kobayashi D - Curr Ther Res Clin Exp (2014)

Blood flow changes in hypoperfused guinea pigs. Guinea pigs received an intramuscular injection of saline and either 0.15 mg/kg naphazoline or 1.5 mg/kg naphazoline as a vasoconstrictor, 150 minutes after anesthesia. Blood flow was measured every 10 minutes for 6 hours. Each point represents the mean (SD) (saline group, n = 8; 0.15 mg/kg naphazoline group, n = 4; 1.5 mg/kg naphazoline group, n = 4). *P < 0.05 (0.15 mg/kg vs. saline). #P < 0.05 (1.5 mg/kg vs saline).
© Copyright Policy - CC BY-NC-SA
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4644240&req=5

f0005: Blood flow changes in hypoperfused guinea pigs. Guinea pigs received an intramuscular injection of saline and either 0.15 mg/kg naphazoline or 1.5 mg/kg naphazoline as a vasoconstrictor, 150 minutes after anesthesia. Blood flow was measured every 10 minutes for 6 hours. Each point represents the mean (SD) (saline group, n = 8; 0.15 mg/kg naphazoline group, n = 4; 1.5 mg/kg naphazoline group, n = 4). *P < 0.05 (0.15 mg/kg vs. saline). #P < 0.05 (1.5 mg/kg vs saline).
Mentions: After administration of 0.15 and 1.5 mg/kg naphazoline, blood flow immediately decreased by 30% and 50%, respectively, compared with baseline. The reduction of blood flow caused by 1.5 mg/kg naphazoline administration persisted until the end of the measurement period (Figure 1).

Bottom Line: Application of MWCs or WCs after subcutaneous CAZ injection led to higher CAZ plasma levels than the mutant prevention concentration for a longer period than was observed for CAZ administration without the application of MWCs or WCs.The application of MWCs or WCs enhanced subcutaneous CAZ absorption by increasing blood flow.MWCs and WCs are considered to be safe and routine methods to induce defecation after surgery on the digestive system; thus, the combination of these methods and subcutaneous CAZ administration is a potential method for treating pneumonia in patients with SMID.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacy Services, National Rehabilitation Center for Children with Disabilities, Tokyo, Japan.

ABSTRACT

Background: Pneumonia is the most common cause of death in patients with severe motor and intellectual disabilities (SMID), and intravenous ceftazidime (CAZ) is a widely used treatment for such infections. However, intravenous administration in patients with SMID may be difficult because of insufficient vascular development.

Objectives: The aim of our study was to determine the feasibility of subcutaneous drug administration by mentholated warm compresses (WMCs) as an alternative delivery method for ceftazidime in patients with SMID.

Methods: CAZ was subcutaneously administered to the abdominal region of naphazoline-treated hypoperfused guinea pigs, which were used as a hemodynamic model of patients with SMID. MWCs or warm compresses (WCs) were applied to the injection site to increase blood flow. We calculated the cumulative CAZ absorption over time by using the deconvolution method.

Results: Application of MWCs or WCs increased blood flow at the administration site and increased CAZ plasma levels. Application of MWCs or WCs after subcutaneous CAZ injection led to higher CAZ plasma levels than the mutant prevention concentration for a longer period than was observed for CAZ administration without the application of MWCs or WCs.

Conclusions: The application of MWCs or WCs enhanced subcutaneous CAZ absorption by increasing blood flow. MWCs and WCs are considered to be safe and routine methods to induce defecation after surgery on the digestive system; thus, the combination of these methods and subcutaneous CAZ administration is a potential method for treating pneumonia in patients with SMID.

No MeSH data available.


Related in: MedlinePlus