Differential Stoichiometry among Core Ribosomal Protein

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Differential Stoichiometry among Core Ribosomal Proteins. Slavov N, Semrau S, Airoldi E, Budnik B, van Oudenaarden A - Cell Rep (2015) Bottom Line: Testing such variability requires direct and precise quantification of RPs.Furthermore, we find that the fitness of cells with a deleted RP-gene is inversely proportional to the enrichment of the corresponding RP in polysomes.Together, our findings support the existence of ribosomes with distinct protein composition and physiological function. View Article: PubMed Central - PubMed Affiliation: Department of Bioengineering, Northeastern University, Boston, MA 02115, USA; Department of Statistics and FAS Center for Systems Biology, Harvard University, Cambridge, MA 02138, USA. Electronic address: nslavov@alum.mit.edu. Show MeSH Major Ribosomal Proteins/chemistry/metabolism Saccharomyces cerevisiae Proteins/chemistry/metabolism Minor Amino Acid Sequence Animals Cell Line Embryonic Stem Cells/metabolism Mice Molecular Sequence Data Protein Binding RNA, Messenger/metabolism Saccharomyces cerevisiae/chemistry Related in: MedlinePlus	© Copyright Policy - CC BY-NC-ND Related In: Results - Collection License Show All Figures getmorefigures.php?uid=PMC4644233&req=5

Differential Stoichiometry among Core Ribosomal Proteins.

Slavov N, Semrau S, Airoldi E, Budnik B, van Oudenaarden A - Cell Rep (2015)

Bottom Line: Testing such variability requires direct and precise quantification of RPs.Furthermore, we find that the fitness of cells with a deleted RP-gene is inversely proportional to the enrichment of the corresponding RP in polysomes.Together, our findings support the existence of ribosomes with distinct protein composition and physiological function.

View Article: PubMed Central - PubMed

Affiliation: Department of Bioengineering, Northeastern University, Boston, MA 02115, USA; Department of Statistics and FAS Center for Systems Biology, Harvard University, Cambridge, MA 02138, USA. Electronic address: nslavov@alum.mit.edu.