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The Fanconi Anemia Pathway Maintains Genome Stability by Coordinating Replication and Transcription.

Schwab RA, Nieminuszczy J, Shah F, Langton J, Lopez Martinez D, Liang CC, Cohn MA, Gibbons RJ, Deans AJ, Niedzwiedz W - Mol. Cell (2015)

Bottom Line: However, how these proteins limit replication stress remains largely elusive.Here we show that conflicts between replication and transcription activate the FA pathway.Finally, we demonstrate that the molecular mechanism by which the FA pathway limits R-loop accumulation requires FANCM translocase activity.

View Article: PubMed Central - PubMed

Affiliation: Department of Oncology, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK.

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The Fanconi Anemia Pathway Maintains Genome Stability by Coordinating Replication and Transcription.

Schwab RA, Nieminuszczy J, Shah F, Langton J, Lopez Martinez D, Liang CC, Cohn MA, Gibbons RJ, Deans AJ, Niedzwiedz W - Mol. Cell (2015)

© Copyright Policy - CC BY
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4644232&req=5

Bottom Line: However, how these proteins limit replication stress remains largely elusive.Here we show that conflicts between replication and transcription activate the FA pathway.Finally, we demonstrate that the molecular mechanism by which the FA pathway limits R-loop accumulation requires FANCM translocase activity.

View Article: PubMed Central - PubMed

Affiliation: Department of Oncology, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK.

Show MeSH
Related in: MedlinePlus