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Attention-deficit/hyperactivity disorder Under Treatment Outcomes Research (AUTOR): a European observational study in pediatric subjects.

Haynes V, Lopez-Romero P, Anand E - Atten Defic Hyperact Disord (2015)

Bottom Line: Among the secondary objectives, initial use of atomoxetine (vs. stimulants) was associated with a significant improvement on the CHIP-CE PRF total score, with an adjusted treatment difference of -6.0 (95 % CI -7.9, -4.1) at 24 months.Additionally, the odds of stability (CGI-ADHD-S ≤ 3 over the 2-year period) were significantly lower for subjects initially responding to stimulants compared with atomoxetine (OR 0.5; 95 % CI 0.3, 0.8).Response to initial treatment with atomoxetine was associated with improved QoL over 2 years.

View Article: PubMed Central - PubMed

Affiliation: Lilly Corporate Center, Eli Lilly and Company, Indianapolis, IN, 46285, USA. ginger.haynes@lilly.com.

ABSTRACT
The ADHD Under Treatment Observational Research (AUTOR) study was a European prospective, observational study that assessed factors associated with changes in ADHD severity, estimated change from baseline in quality of life (QoL), and characterized changes in ADHD symptoms over a 2-year period as a function of baseline treatment. The primary objective was to identify factors associated with worsening in ADHD severity during a 2-year follow-up period for subjects aged 6-17 years, who were receiving the same pharmacotherapy for 3-8 months before enrollment and had a Clinical Global Impression (CGI)-ADHD-Severity score of mild/lower and a CGI-ADHD-Improvement score of improved/very much improved. Multivariate logistic regression examined the association of factors with worsening in ADHD. Mixed-model repeated measures regression analyzed QoL in terms of change from baseline in CHIP-CE PRF scores. There were 704 subjects analyzed. Variables associated with worsening ADHD severity were parental occupation, poorer school outcomes, and use of psychoeducation; baseline treatment was not significant. Among the secondary objectives, initial use of atomoxetine (vs. stimulants) was associated with a significant improvement on the CHIP-CE PRF total score, with an adjusted treatment difference of -6.0 (95 % CI -7.9, -4.1) at 24 months. Additionally, the odds of stability (CGI-ADHD-S ≤ 3 over the 2-year period) were significantly lower for subjects initially responding to stimulants compared with atomoxetine (OR 0.5; 95 % CI 0.3, 0.8). ADHD symptom worsening was associated with initial use of psychoeducation, parental occupation, and poorer school outcomes. Response to initial treatment with atomoxetine was associated with improved QoL over 2 years.

No MeSH data available.


Related in: MedlinePlus

Countries participating in AUTOR
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Related In: Results  -  Collection


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Fig1: Countries participating in AUTOR

Mentions: Of the 704 subjects in the study, the majority were Caucasian (98.9 %) and male (81.5 %). Nearly 80 % of the subjects completed the 2-year study. Table 3 summarizes the physical characteristics, comorbidities, prior treatment duration, and disposition of the sample. Figure 1 summarizes the subjects by country. The majority of subjects were recruited from Italy, Romania, and Greece, and the pattern of allocation to treatment reflects the timing of medication availability in those regions.Table 3


Attention-deficit/hyperactivity disorder Under Treatment Outcomes Research (AUTOR): a European observational study in pediatric subjects.

Haynes V, Lopez-Romero P, Anand E - Atten Defic Hyperact Disord (2015)

Countries participating in AUTOR
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4644194&req=5

Fig1: Countries participating in AUTOR
Mentions: Of the 704 subjects in the study, the majority were Caucasian (98.9 %) and male (81.5 %). Nearly 80 % of the subjects completed the 2-year study. Table 3 summarizes the physical characteristics, comorbidities, prior treatment duration, and disposition of the sample. Figure 1 summarizes the subjects by country. The majority of subjects were recruited from Italy, Romania, and Greece, and the pattern of allocation to treatment reflects the timing of medication availability in those regions.Table 3

Bottom Line: Among the secondary objectives, initial use of atomoxetine (vs. stimulants) was associated with a significant improvement on the CHIP-CE PRF total score, with an adjusted treatment difference of -6.0 (95 % CI -7.9, -4.1) at 24 months.Additionally, the odds of stability (CGI-ADHD-S ≤ 3 over the 2-year period) were significantly lower for subjects initially responding to stimulants compared with atomoxetine (OR 0.5; 95 % CI 0.3, 0.8).Response to initial treatment with atomoxetine was associated with improved QoL over 2 years.

View Article: PubMed Central - PubMed

Affiliation: Lilly Corporate Center, Eli Lilly and Company, Indianapolis, IN, 46285, USA. ginger.haynes@lilly.com.

ABSTRACT
The ADHD Under Treatment Observational Research (AUTOR) study was a European prospective, observational study that assessed factors associated with changes in ADHD severity, estimated change from baseline in quality of life (QoL), and characterized changes in ADHD symptoms over a 2-year period as a function of baseline treatment. The primary objective was to identify factors associated with worsening in ADHD severity during a 2-year follow-up period for subjects aged 6-17 years, who were receiving the same pharmacotherapy for 3-8 months before enrollment and had a Clinical Global Impression (CGI)-ADHD-Severity score of mild/lower and a CGI-ADHD-Improvement score of improved/very much improved. Multivariate logistic regression examined the association of factors with worsening in ADHD. Mixed-model repeated measures regression analyzed QoL in terms of change from baseline in CHIP-CE PRF scores. There were 704 subjects analyzed. Variables associated with worsening ADHD severity were parental occupation, poorer school outcomes, and use of psychoeducation; baseline treatment was not significant. Among the secondary objectives, initial use of atomoxetine (vs. stimulants) was associated with a significant improvement on the CHIP-CE PRF total score, with an adjusted treatment difference of -6.0 (95 % CI -7.9, -4.1) at 24 months. Additionally, the odds of stability (CGI-ADHD-S ≤ 3 over the 2-year period) were significantly lower for subjects initially responding to stimulants compared with atomoxetine (OR 0.5; 95 % CI 0.3, 0.8). ADHD symptom worsening was associated with initial use of psychoeducation, parental occupation, and poorer school outcomes. Response to initial treatment with atomoxetine was associated with improved QoL over 2 years.

No MeSH data available.


Related in: MedlinePlus