Limits...
Association of epicardial adipose tissue thickness and inflammation parameters with CHA2DS2-VASASc score in patients with nonvalvular atrial fibrillation.

Akdag S, Simsek H, Sahin M, Akyol A, Duz R, Babat N - Ther Clin Risk Manag (2015)

Bottom Line: The study included 96 consecutive patients with AF and 52 age- and sex-matched control subjects.Moreover, CHA2DS2-VASc score was found to be positively correlated with EAT (r=0.623, P<0.001), MPV (r=0.350, P=0.004), PLR (r=0.398, P=0.001), and NLR (r=0.518, P<0.001).Our study results demonstrated that EAT thickness, MPV, PLR, and NLR were associated with the thromboembolic risk exhibited by CHA2DS2-VASc score in patients with nonvalvular AF.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Yuzuncu Yil University Medical Faculty, Van, Turkey.

ABSTRACT

Background: Epicardial adipose tissue (EAT), mean platelet volume (MPV), platelet-to- lymphocyte ratio (PLR), and neutrophil-to-lymphocyte ratio (NLR) have been shown to be helpful in predicting adverse cardiovascular events. However, to date, in the literature, there have been no studies demonstrating the relationship between EAT, MPV, PLR, NLR, and thromboembolism risk in atrial fibrillation (AF). Therefore, we examined the relationship between EAT, MPV, PLR, NLR, and CHA2DS2-VASc score used for the evaluation of thromboembolism risk in patients with AF.

Methods: The study included 96 consecutive patients with AF and 52 age- and sex-matched control subjects. We calculated CHA2DS2-VASc risk score for each patient and measured baseline EAT thickness, MPV, PLR, NLR, left atrial volume index, and left ventricular ejection fraction.

Results: The group with high CHA2DS2-VASc score had higher EAT (7.2±1.5 vs 5.9±1.2 mm, P<0.001), MPV (9.1±1.1 vs 8.4±1.0 fL, P=0.004), PLR (152.3±28.4 vs 126.7±25.4, P=0.001), and NLR (4.0±1.6 vs 3.2±1.3, P<0.001) compared to group with low-intermediate CHA2DS2-VASc score. Moreover, CHA2DS2-VASc score was found to be positively correlated with EAT (r=0.623, P<0.001), MPV (r=0.350, P=0.004), PLR (r=0.398, P=0.001), and NLR (r=0.518, P<0.001).

Conclusion: Our study results demonstrated that EAT thickness, MPV, PLR, and NLR were associated with the thromboembolic risk exhibited by CHA2DS2-VASc score in patients with nonvalvular AF.

No MeSH data available.


Related in: MedlinePlus

Correlation plots between MPV and CHA2DS2-VASc score.Abbreviation: MPV, mean platelet volume.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4644180&req=5

f2-tcrm-11-1675: Correlation plots between MPV and CHA2DS2-VASc score.Abbreviation: MPV, mean platelet volume.

Mentions: A total of 148 patients (96 patients with nonvalvular AF and 52 control subjects) were included in the present study. Baseline demographic, clinical, and laboratory characteristics of the nonvalvular AF and the control groups are presented in Table 2. The median CHA2DS2-VASc score was 2, and 53.1% of the patients were in the high CHA2DS2-VASc group. Within the nonvalvular AF group, there were 51 patients with high CHA2DS2-VASc score and 45 patients with low-intermediate CHA2DS2-VASc score. Of all the patients, 22.9% of the cases had paroxysmal, 16.7% had persistent, and 60.4% had permanent AF. Other baseline characteristics and previous medications are shown in Table 3. Patients with nonvalvular AF had significantly higher EAT (6.6±1.3 vs 4.9±1.0 mm, P<0.001), MPV (8.9±1.1 vs 7.8±1.0 fL, P<0.001), PLR (140.3±24.2 vs 119.3±21.9, P=0.002), and NLR (3.6±1.5 vs 2.9±1.3, P<0.001) compared to the control subjects. LA volume index (P<0.001) was significantly higher in the nonvalvular AF group compared to the controls. However, LVEF (P<0.001) was significantly lower in the nonvalvular AF group compared to the controls (Table 2). High CHA2DS2-VASc group had higher EAT (7.2±1.5 vs 5.9±1.2 mm, P<0.001), MPV (9.1±1.1 vs 8.4±1.0 fL, P=0.004), PLR (152.3±28.4 vs 126.7±25.4, P=0.001), and NLR (4.0±1.6 vs 3.2±1.3, P<0.001) compared to the low-intermediate CHA2DS2-VASc group. Moreover, age (P<0.001), LA volume index (P<0.001), hypertension (P<0.001), and diabetes (P=0.006) were significantly higher in the high CHA2DS2-VASc group compared to the low-intermediate CHA2DS2-VASc group. However, LVEF (P<0.001) was significantly lower in the high CHA2DS2-VASc group compared to the low-intermediate CHA2DS2-VASc group (Table 3). Moreover, CHA2DS2-VASc score was found to be positively correlated with EAT (r=0.623, P<0.001) (Figure 1), MPV (r=0.350, P=0.004) (Figure 2), PLR (r=0.398, P=0.001) (Figure 3), and NLR (r=0.518, P<0.001) (Figure 4).


Association of epicardial adipose tissue thickness and inflammation parameters with CHA2DS2-VASASc score in patients with nonvalvular atrial fibrillation.

Akdag S, Simsek H, Sahin M, Akyol A, Duz R, Babat N - Ther Clin Risk Manag (2015)

Correlation plots between MPV and CHA2DS2-VASc score.Abbreviation: MPV, mean platelet volume.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4644180&req=5

f2-tcrm-11-1675: Correlation plots between MPV and CHA2DS2-VASc score.Abbreviation: MPV, mean platelet volume.
Mentions: A total of 148 patients (96 patients with nonvalvular AF and 52 control subjects) were included in the present study. Baseline demographic, clinical, and laboratory characteristics of the nonvalvular AF and the control groups are presented in Table 2. The median CHA2DS2-VASc score was 2, and 53.1% of the patients were in the high CHA2DS2-VASc group. Within the nonvalvular AF group, there were 51 patients with high CHA2DS2-VASc score and 45 patients with low-intermediate CHA2DS2-VASc score. Of all the patients, 22.9% of the cases had paroxysmal, 16.7% had persistent, and 60.4% had permanent AF. Other baseline characteristics and previous medications are shown in Table 3. Patients with nonvalvular AF had significantly higher EAT (6.6±1.3 vs 4.9±1.0 mm, P<0.001), MPV (8.9±1.1 vs 7.8±1.0 fL, P<0.001), PLR (140.3±24.2 vs 119.3±21.9, P=0.002), and NLR (3.6±1.5 vs 2.9±1.3, P<0.001) compared to the control subjects. LA volume index (P<0.001) was significantly higher in the nonvalvular AF group compared to the controls. However, LVEF (P<0.001) was significantly lower in the nonvalvular AF group compared to the controls (Table 2). High CHA2DS2-VASc group had higher EAT (7.2±1.5 vs 5.9±1.2 mm, P<0.001), MPV (9.1±1.1 vs 8.4±1.0 fL, P=0.004), PLR (152.3±28.4 vs 126.7±25.4, P=0.001), and NLR (4.0±1.6 vs 3.2±1.3, P<0.001) compared to the low-intermediate CHA2DS2-VASc group. Moreover, age (P<0.001), LA volume index (P<0.001), hypertension (P<0.001), and diabetes (P=0.006) were significantly higher in the high CHA2DS2-VASc group compared to the low-intermediate CHA2DS2-VASc group. However, LVEF (P<0.001) was significantly lower in the high CHA2DS2-VASc group compared to the low-intermediate CHA2DS2-VASc group (Table 3). Moreover, CHA2DS2-VASc score was found to be positively correlated with EAT (r=0.623, P<0.001) (Figure 1), MPV (r=0.350, P=0.004) (Figure 2), PLR (r=0.398, P=0.001) (Figure 3), and NLR (r=0.518, P<0.001) (Figure 4).

Bottom Line: The study included 96 consecutive patients with AF and 52 age- and sex-matched control subjects.Moreover, CHA2DS2-VASc score was found to be positively correlated with EAT (r=0.623, P<0.001), MPV (r=0.350, P=0.004), PLR (r=0.398, P=0.001), and NLR (r=0.518, P<0.001).Our study results demonstrated that EAT thickness, MPV, PLR, and NLR were associated with the thromboembolic risk exhibited by CHA2DS2-VASc score in patients with nonvalvular AF.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Yuzuncu Yil University Medical Faculty, Van, Turkey.

ABSTRACT

Background: Epicardial adipose tissue (EAT), mean platelet volume (MPV), platelet-to- lymphocyte ratio (PLR), and neutrophil-to-lymphocyte ratio (NLR) have been shown to be helpful in predicting adverse cardiovascular events. However, to date, in the literature, there have been no studies demonstrating the relationship between EAT, MPV, PLR, NLR, and thromboembolism risk in atrial fibrillation (AF). Therefore, we examined the relationship between EAT, MPV, PLR, NLR, and CHA2DS2-VASc score used for the evaluation of thromboembolism risk in patients with AF.

Methods: The study included 96 consecutive patients with AF and 52 age- and sex-matched control subjects. We calculated CHA2DS2-VASc risk score for each patient and measured baseline EAT thickness, MPV, PLR, NLR, left atrial volume index, and left ventricular ejection fraction.

Results: The group with high CHA2DS2-VASc score had higher EAT (7.2±1.5 vs 5.9±1.2 mm, P<0.001), MPV (9.1±1.1 vs 8.4±1.0 fL, P=0.004), PLR (152.3±28.4 vs 126.7±25.4, P=0.001), and NLR (4.0±1.6 vs 3.2±1.3, P<0.001) compared to group with low-intermediate CHA2DS2-VASc score. Moreover, CHA2DS2-VASc score was found to be positively correlated with EAT (r=0.623, P<0.001), MPV (r=0.350, P=0.004), PLR (r=0.398, P=0.001), and NLR (r=0.518, P<0.001).

Conclusion: Our study results demonstrated that EAT thickness, MPV, PLR, and NLR were associated with the thromboembolic risk exhibited by CHA2DS2-VASc score in patients with nonvalvular AF.

No MeSH data available.


Related in: MedlinePlus