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Implication of lncRNAs in pathogenesis of esophageal cancer.

Tang WW, Wu Q, Li SQ, Tong YS, Liu ZH, Yang TX, Xu Y, Cao XF - Onco Targets Ther (2015)

Bottom Line: Long non-coding RNAs (lncRNAs), transcripts as longer than 200 nt in length with a great number of varieties in human genomics, play important roles in the regulation of genetics and epigenetics including gene transcription and post-transcription.Increasing evidence have demonstrated the upregulation of lncRNAs in tumorigenesis and metastasis of esophageal cancer (EC), a type of malignant tumors particularly in Asia.In this review, we briefly discuss the profiles and functions of lncRNAs involved in the progression of EC, which may provide a new approach to improve EC diagnosis and treatment.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgical Oncology, Nanjing First Hospital, Nanjing Medical University, Nanjing, People's Republic of China.

ABSTRACT
Long non-coding RNAs (lncRNAs), transcripts as longer than 200 nt in length with a great number of varieties in human genomics, play important roles in the regulation of genetics and epigenetics including gene transcription and post-transcription. Increasing evidence have demonstrated the upregulation of lncRNAs in tumorigenesis and metastasis of esophageal cancer (EC), a type of malignant tumors particularly in Asia. In this review, we briefly discuss the profiles and functions of lncRNAs involved in the progression of EC, which may provide a new approach to improve EC diagnosis and treatment.

No MeSH data available.


Related in: MedlinePlus

Molecular mechanisms of lncRNAs.Abbreviation: lncRNAs, long non-coding RNAs.
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f2-ott-8-3219: Molecular mechanisms of lncRNAs.Abbreviation: lncRNAs, long non-coding RNAs.

Mentions: In past decades, the common knowledge suggested that long non-coding transcripts were simply transcriptional noises or cloning artifacts.11,12 Nonetheless, tight evolutionary conservation and strict gene regulation of lncRNAs predict that these transcripts are important in both normal physiological processes and abnormal pathological developments.13–15 Wang and Chang distilled the myriad functions of lncRNAs into four archetypes of molecular mechanisms (Figure 2).16


Implication of lncRNAs in pathogenesis of esophageal cancer.

Tang WW, Wu Q, Li SQ, Tong YS, Liu ZH, Yang TX, Xu Y, Cao XF - Onco Targets Ther (2015)

Molecular mechanisms of lncRNAs.Abbreviation: lncRNAs, long non-coding RNAs.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4644178&req=5

f2-ott-8-3219: Molecular mechanisms of lncRNAs.Abbreviation: lncRNAs, long non-coding RNAs.
Mentions: In past decades, the common knowledge suggested that long non-coding transcripts were simply transcriptional noises or cloning artifacts.11,12 Nonetheless, tight evolutionary conservation and strict gene regulation of lncRNAs predict that these transcripts are important in both normal physiological processes and abnormal pathological developments.13–15 Wang and Chang distilled the myriad functions of lncRNAs into four archetypes of molecular mechanisms (Figure 2).16

Bottom Line: Long non-coding RNAs (lncRNAs), transcripts as longer than 200 nt in length with a great number of varieties in human genomics, play important roles in the regulation of genetics and epigenetics including gene transcription and post-transcription.Increasing evidence have demonstrated the upregulation of lncRNAs in tumorigenesis and metastasis of esophageal cancer (EC), a type of malignant tumors particularly in Asia.In this review, we briefly discuss the profiles and functions of lncRNAs involved in the progression of EC, which may provide a new approach to improve EC diagnosis and treatment.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgical Oncology, Nanjing First Hospital, Nanjing Medical University, Nanjing, People's Republic of China.

ABSTRACT
Long non-coding RNAs (lncRNAs), transcripts as longer than 200 nt in length with a great number of varieties in human genomics, play important roles in the regulation of genetics and epigenetics including gene transcription and post-transcription. Increasing evidence have demonstrated the upregulation of lncRNAs in tumorigenesis and metastasis of esophageal cancer (EC), a type of malignant tumors particularly in Asia. In this review, we briefly discuss the profiles and functions of lncRNAs involved in the progression of EC, which may provide a new approach to improve EC diagnosis and treatment.

No MeSH data available.


Related in: MedlinePlus