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Engineering iodine-doped carbon dots as dual-modal probes for fluorescence and X-ray CT imaging.

Zhang M, Ju H, Zhang L, Sun M, Zhou Z, Dai Z, Zhang L, Gong A, Wu C, Du F - Int J Nanomedicine (2015)

Bottom Line: Importantly, I-doped CDs displayed superior X-ray attenuation properties in vitro and excellent biocompatibility.After intravenous injection, I-doped CDs were distributed throughout the body and excreted by renal clearance.These findings validated that I-doped CDs with high X-ray attenuation potency and favorable photoluminescence show great promise for biomedical research and disease diagnosis.

View Article: PubMed Central - PubMed

Affiliation: School of Medicine, Jiangsu University, Zhenjiang, People's Republic of China.

ABSTRACT
X-ray computed tomography (CT) is the most commonly used imaging technique for noninvasive diagnosis of disease. In order to improve tissue specificity and prevent adverse effects, we report the design and synthesis of iodine-doped carbon dots (I-doped CDs) as efficient CT contrast agents and fluorescence probe by a facile bottom-up hydrothermal carbonization process. The as-prepared I-doped CDs are monodispersed spherical nanoparticles (a diameter of ~2.7 nm) with favorable dispersibility and colloidal stability in water. The aqueous solution of I-doped CDs showed wavelength-dependent excitation and stable photoluminescence similar to traditional carbon quantum dots. Importantly, I-doped CDs displayed superior X-ray attenuation properties in vitro and excellent biocompatibility. After intravenous injection, I-doped CDs were distributed throughout the body and excreted by renal clearance. These findings validated that I-doped CDs with high X-ray attenuation potency and favorable photoluminescence show great promise for biomedical research and disease diagnosis.

No MeSH data available.


Related in: MedlinePlus

Morphology characterization of I-doped CDs.Notes: (A) Low and high (inset) magnification TEM images. (B) The diameter distribution of prepared I-doped CDs.Abbreviations: I-doped CDs, iodine-doped carbon dots; TEM, transmission electron microscopy.
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f2-ijn-10-6943: Morphology characterization of I-doped CDs.Notes: (A) Low and high (inset) magnification TEM images. (B) The diameter distribution of prepared I-doped CDs.Abbreviations: I-doped CDs, iodine-doped carbon dots; TEM, transmission electron microscopy.

Mentions: The successful preparation of I-doped CDs was carried out by using iodixanol as iodine source and glycine as surface passivation agent based on the scheme given in Figure 1. The morphology of the synthesized I-doped CDs was analyzed by transmission electron microscopy. As shown in Figure 2A, the I-doped CDs exhibited uniform dispersion and discrete quasispherical shape without apparent aggregation. Figure 2B shows that the diameter distribution of I-doped CDs matched well with Gaussian fitting curve. The average diameter of I-doped CDs was approximately 2.7 nm, which was determined by statistical analysis of more than 100 particles by using the ImageJ software (National Institutes of Health, Bethesda, MD, USA). Meanwhile, these nanoparticles were amorphous without any lattices, which was consistent with other reports on CDs.20,21


Engineering iodine-doped carbon dots as dual-modal probes for fluorescence and X-ray CT imaging.

Zhang M, Ju H, Zhang L, Sun M, Zhou Z, Dai Z, Zhang L, Gong A, Wu C, Du F - Int J Nanomedicine (2015)

Morphology characterization of I-doped CDs.Notes: (A) Low and high (inset) magnification TEM images. (B) The diameter distribution of prepared I-doped CDs.Abbreviations: I-doped CDs, iodine-doped carbon dots; TEM, transmission electron microscopy.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4644166&req=5

f2-ijn-10-6943: Morphology characterization of I-doped CDs.Notes: (A) Low and high (inset) magnification TEM images. (B) The diameter distribution of prepared I-doped CDs.Abbreviations: I-doped CDs, iodine-doped carbon dots; TEM, transmission electron microscopy.
Mentions: The successful preparation of I-doped CDs was carried out by using iodixanol as iodine source and glycine as surface passivation agent based on the scheme given in Figure 1. The morphology of the synthesized I-doped CDs was analyzed by transmission electron microscopy. As shown in Figure 2A, the I-doped CDs exhibited uniform dispersion and discrete quasispherical shape without apparent aggregation. Figure 2B shows that the diameter distribution of I-doped CDs matched well with Gaussian fitting curve. The average diameter of I-doped CDs was approximately 2.7 nm, which was determined by statistical analysis of more than 100 particles by using the ImageJ software (National Institutes of Health, Bethesda, MD, USA). Meanwhile, these nanoparticles were amorphous without any lattices, which was consistent with other reports on CDs.20,21

Bottom Line: Importantly, I-doped CDs displayed superior X-ray attenuation properties in vitro and excellent biocompatibility.After intravenous injection, I-doped CDs were distributed throughout the body and excreted by renal clearance.These findings validated that I-doped CDs with high X-ray attenuation potency and favorable photoluminescence show great promise for biomedical research and disease diagnosis.

View Article: PubMed Central - PubMed

Affiliation: School of Medicine, Jiangsu University, Zhenjiang, People's Republic of China.

ABSTRACT
X-ray computed tomography (CT) is the most commonly used imaging technique for noninvasive diagnosis of disease. In order to improve tissue specificity and prevent adverse effects, we report the design and synthesis of iodine-doped carbon dots (I-doped CDs) as efficient CT contrast agents and fluorescence probe by a facile bottom-up hydrothermal carbonization process. The as-prepared I-doped CDs are monodispersed spherical nanoparticles (a diameter of ~2.7 nm) with favorable dispersibility and colloidal stability in water. The aqueous solution of I-doped CDs showed wavelength-dependent excitation and stable photoluminescence similar to traditional carbon quantum dots. Importantly, I-doped CDs displayed superior X-ray attenuation properties in vitro and excellent biocompatibility. After intravenous injection, I-doped CDs were distributed throughout the body and excreted by renal clearance. These findings validated that I-doped CDs with high X-ray attenuation potency and favorable photoluminescence show great promise for biomedical research and disease diagnosis.

No MeSH data available.


Related in: MedlinePlus