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The association between XRCC1 Arg399Gln polymorphism and risk of leukemia in different populations: a meta-analysis of case-control studies.

Wang F, Zhao Q, He HR, Zhai YJ, Lu J, Hu HB, Zhou JS, Yang YH, Li YJ - Onco Targets Ther (2015)

Bottom Line: The XRCC1 Arg399Gln SNP was found to be associated with increased childhood risk of acute lymphoblastic leukemia among Asians under the dominant (odds ratio [OR] 2.11, 95% confidence interval [CI] 1.50-2.97, P<0.0001), allele contrast (OR 1.72, 95% CI 1.33-2.23, P<0.0001), and homozygote contrast (OR 2.34, 95% CI 1.25-4.36, P=0.008) models.However, no association was found in Caucasians between the SNP and risk of either chronic myeloid leukemia or chronic lymphocytic leukemia under any contrast model.The findings of the current meta-analysis indicate that the XRCC1 Arg399Gln SNP is a risk factor for childhood lymphoblastic leukemia in Asians.

View Article: PubMed Central - PubMed

Affiliation: Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Centre, Xi'an, People's Republic of China ; College of Pharmacy, Xi'an Medical University, Xi'an, People's Republic of China.

ABSTRACT

Background: Associations between Arg399Gln single-nucleotide polymorphism (SNP) in the XRCC1 gene and leukemia susceptibility have been studied extensively, however, the results are inconsistent. The aim of this study was to determine these associations using meta-analytical methods.

Methods: A meta-analysis was performed to examine the associations between XRCC1 Arg399-Gln SNP and leukemia risk. A literature search of PubMed and Web of Science databases was conducted to identify relevant studies published up to March 10, 2015. The references of the retrieved articles were also screened. All the statistical analyses were conducted using Review Manager software.

Results: The XRCC1 Arg399Gln SNP was found to be associated with increased childhood risk of acute lymphoblastic leukemia among Asians under the dominant (odds ratio [OR] 2.11, 95% confidence interval [CI] 1.50-2.97, P<0.0001), allele contrast (OR 1.72, 95% CI 1.33-2.23, P<0.0001), and homozygote contrast (OR 2.34, 95% CI 1.25-4.36, P=0.008) models. However, no association was found in Caucasians between the SNP and risk of either chronic myeloid leukemia or chronic lymphocytic leukemia under any contrast model.

Conclusion: The findings of the current meta-analysis indicate that the XRCC1 Arg399Gln SNP is a risk factor for childhood lymphoblastic leukemia in Asians.

No MeSH data available.


Related in: MedlinePlus

Meta-analysis of the association between XRCC1 Arg399Gln SNP and ALL risk under the recessive model (A), the dominant model (B), the allele contrast model (C), and the homozygote contrast model (D).Abbreviations: SNP, single-nucleotide polymorphism; ALL, acute lymphocytic leukemia; CI, confidence interval; M–H, Mantel–Haenszel.
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f4-ott-8-3277: Meta-analysis of the association between XRCC1 Arg399Gln SNP and ALL risk under the recessive model (A), the dominant model (B), the allele contrast model (C), and the homozygote contrast model (D).Abbreviations: SNP, single-nucleotide polymorphism; ALL, acute lymphocytic leukemia; CI, confidence interval; M–H, Mantel–Haenszel.

Mentions: As the different results obtained among the included studies could be attributable to population differences in Arg399Gln mutation frequency or linkage disequilibrium block, subgroup analysis according to race was conducted. In the Caucasian and Asian subgroups, heterogeneity was not found to be large (I2<50%) under any contrast model. Therefore, the fixed-effects model was used in Caucasian and Asian subgroups under any contrast model. The Arg399Gln SNP was then found to significantly increase the risk of childhood ALL only among Asians, under the dominant (OR 2.11, 95% CI 1.50–2.97, P<0.0001; Figure 4B), allele contrast (OR 1.72, 95% CI 1.33–2.23, P<0.0001; Figure 4C), and homozygote contrast (OR 2.34, 95% CI 1.25–4.36, P=0.008; Figure 4D) models. No association was observed under the recessive model (OR 1.70, 95% CI 0.94–3.08, P=0.08; Figure 4A). Furthermore, no association between the XRCC1 Arg399Gln SNP and risk of childhood ALL was found under any contrast model among Caucasian or mixed-race populations (Figure 4).


The association between XRCC1 Arg399Gln polymorphism and risk of leukemia in different populations: a meta-analysis of case-control studies.

Wang F, Zhao Q, He HR, Zhai YJ, Lu J, Hu HB, Zhou JS, Yang YH, Li YJ - Onco Targets Ther (2015)

Meta-analysis of the association between XRCC1 Arg399Gln SNP and ALL risk under the recessive model (A), the dominant model (B), the allele contrast model (C), and the homozygote contrast model (D).Abbreviations: SNP, single-nucleotide polymorphism; ALL, acute lymphocytic leukemia; CI, confidence interval; M–H, Mantel–Haenszel.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4644162&req=5

f4-ott-8-3277: Meta-analysis of the association between XRCC1 Arg399Gln SNP and ALL risk under the recessive model (A), the dominant model (B), the allele contrast model (C), and the homozygote contrast model (D).Abbreviations: SNP, single-nucleotide polymorphism; ALL, acute lymphocytic leukemia; CI, confidence interval; M–H, Mantel–Haenszel.
Mentions: As the different results obtained among the included studies could be attributable to population differences in Arg399Gln mutation frequency or linkage disequilibrium block, subgroup analysis according to race was conducted. In the Caucasian and Asian subgroups, heterogeneity was not found to be large (I2<50%) under any contrast model. Therefore, the fixed-effects model was used in Caucasian and Asian subgroups under any contrast model. The Arg399Gln SNP was then found to significantly increase the risk of childhood ALL only among Asians, under the dominant (OR 2.11, 95% CI 1.50–2.97, P<0.0001; Figure 4B), allele contrast (OR 1.72, 95% CI 1.33–2.23, P<0.0001; Figure 4C), and homozygote contrast (OR 2.34, 95% CI 1.25–4.36, P=0.008; Figure 4D) models. No association was observed under the recessive model (OR 1.70, 95% CI 0.94–3.08, P=0.08; Figure 4A). Furthermore, no association between the XRCC1 Arg399Gln SNP and risk of childhood ALL was found under any contrast model among Caucasian or mixed-race populations (Figure 4).

Bottom Line: The XRCC1 Arg399Gln SNP was found to be associated with increased childhood risk of acute lymphoblastic leukemia among Asians under the dominant (odds ratio [OR] 2.11, 95% confidence interval [CI] 1.50-2.97, P<0.0001), allele contrast (OR 1.72, 95% CI 1.33-2.23, P<0.0001), and homozygote contrast (OR 2.34, 95% CI 1.25-4.36, P=0.008) models.However, no association was found in Caucasians between the SNP and risk of either chronic myeloid leukemia or chronic lymphocytic leukemia under any contrast model.The findings of the current meta-analysis indicate that the XRCC1 Arg399Gln SNP is a risk factor for childhood lymphoblastic leukemia in Asians.

View Article: PubMed Central - PubMed

Affiliation: Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Centre, Xi'an, People's Republic of China ; College of Pharmacy, Xi'an Medical University, Xi'an, People's Republic of China.

ABSTRACT

Background: Associations between Arg399Gln single-nucleotide polymorphism (SNP) in the XRCC1 gene and leukemia susceptibility have been studied extensively, however, the results are inconsistent. The aim of this study was to determine these associations using meta-analytical methods.

Methods: A meta-analysis was performed to examine the associations between XRCC1 Arg399-Gln SNP and leukemia risk. A literature search of PubMed and Web of Science databases was conducted to identify relevant studies published up to March 10, 2015. The references of the retrieved articles were also screened. All the statistical analyses were conducted using Review Manager software.

Results: The XRCC1 Arg399Gln SNP was found to be associated with increased childhood risk of acute lymphoblastic leukemia among Asians under the dominant (odds ratio [OR] 2.11, 95% confidence interval [CI] 1.50-2.97, P<0.0001), allele contrast (OR 1.72, 95% CI 1.33-2.23, P<0.0001), and homozygote contrast (OR 2.34, 95% CI 1.25-4.36, P=0.008) models. However, no association was found in Caucasians between the SNP and risk of either chronic myeloid leukemia or chronic lymphocytic leukemia under any contrast model.

Conclusion: The findings of the current meta-analysis indicate that the XRCC1 Arg399Gln SNP is a risk factor for childhood lymphoblastic leukemia in Asians.

No MeSH data available.


Related in: MedlinePlus